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Trance and possession symptoms along with religious and mystic experiences are commonly seen in Indian patients. Though, commonly conceptualized under the rubric of dissociative disorders, possession like symptoms can be present in variety of clinical conditions. Trance and possession syndrome results from a variety of central nervous system involvement. We report here such a case with lesion in the basal ganglia and fronto-patietal lobes. Pathophysiology and cultural connotation of the symptoms is discussed.