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Luria-Nebraska Neuro-psychological Battery, is now an established tool to assess brain damage in recent years. This test battery has been reported to be very useful to find out functional organization of the brain. The biological basis of psychiatry is also now well explained. The present study is directed towards the neuro-psychological functioning of schizophrenic disorder, and the findings are discussed in the light of biological researches. The pattern of performance of schizophrenia on Luria-Nebraska Neuro-psychological battery is indicating the possibility of combined cerebral dysfunction, more towards left hemisphere functions. No single localization was found responsible for this illness. Limitations of present study, and need for well organized further research is indicated using advance technology of brain imaging techniques and neuro-psychological profile of brain functioning, would be helpful for the rehabilitation purposes and to understand the illness better.