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J Indian Assoc Pediatr Surg. 2010 Apr-Jun; 15(2): 76.
PMCID: PMC2952785

Neonatal adrenal hemorrhage and neonatal jaundice


I read the recent publication on neonatal adrenal hemorrhage by Qureshi et al. with great interest.[1] The authors demonstrated that neonatal adrenal hemorrhage could present with late-onset neonatal jaundice. Indeed, neonatal adrenal hemorrhage is a rare neonatal disorder, which might cause early neonatal jaundice and neonatal anemia (due to extravascular blood loss). The observation on the late-onset neonatal jaundice in this case is an interesting point to be discussed.[2] Qureshi et al. concluded that this observation was due to neonatal adrenal hemorrhage.[2] There might be other possible coexisting causes of late-onset neonatal jaundice (such as breast milk jaundice, sepsis, conjugation defect, thyroid and metabolic disorder, etc.) in this case that is not completely investigated.[3]


1. Qureshi UA, Ahmad N, Rasool A, Choh S. Neonatal adrenal hemorrhage presenting as late onset neonatal jaundice. J Indian Assoc Pediatr Surg. 2009;14:221–3. [PMC free article] [PubMed]
2. Velaphi SC, Perlman JM. Neonatal adrenal hemorrhage: Clinical and abdominal sonographic findings. Clin Pediatr (Phila) 2001;40:545–8. [PubMed]
3. Kirk JM. Neonatal jaundice: A critical review of the role and practice of bilirubin analysis. Ann Clin Biochem. 2008;45:452–62. [PubMed]

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