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The relation between site of stroke and cognitive deficits, anxiety, depression, and quality of life was done in 40 stroke patients using Blessed Mental Status Test, Hospital Anxiety and Depression Scale, Manchester short assessment of quality of life scale. Lesion localization was done by CT scan. In a relatively short period after stroke, specificity for any hemisphere or arterial territory of any side (left or right) was not evident for anxiety, depression, cognitive deficits or level of QOL. Considering the arterial territories involved, MCA infarcts were associated with greater cognitive deficits, anxiety and poor QOL. ACA infarcts had least anxiety. PCA infarcts were associated with better QOL and least cognitive deficits.