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Indian J Psychiatry. 2003 Jul-Sep; 45(3): 158–160.
PMCID: PMC2952161

Influence of duration of untreated psychosis on the short-term outcome of drug-free schizophrenia patients

Abstract

Western studies in the recent past have suggested that reducing the duration of untreated psychosis (DUP) is associated with better control of symptoms of schizophrenia. The present investigation attempts to assess the influence of duration of untreated psychosis and other predictors on the outcome of schizophrenia, six weeks after the treatment. Data of 45 DSM-IV schizophrenia patients (Mean age 31 ± 9.2; 27 males) who were treated for the first time formed the sample. Based on the clinical notes in files two psychiatrists independently rated the outcome at 6-8 weeks of neuroleptic treatment. The inter rater agreement was good. Improved and unimproved groups did not differ on any variables except the duration of untreated psychosis. Duration of untreated psychosis was longer in the unimproved group. In a logistic regression model, only duration of untreated psychosis emerged as a significant predictor (OR= 0.9854. with 95% Cl= 0.9717 - 0.9993; p=0.039). DUP affects acute outcome in schizophrenia.

Keywords: Acute outcome, DUP. Logistic Regression, Predictors, Psychosis, Schizophrenia

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Craig TJ, Bromet EJ, Fennig S, Tanenberg-Karant M, Lavelle J, Galambos N. Is there an association between duration of untreated psychosis and 24-month clinical outcome in a first-admission series? Am J Psychiatry. 2000 Jan;157(1):60–66. [PubMed]
  • Fenton WS, McGlashan TH. Sustained remission in drug-free schizophrenic patients. Am J Psychiatry. 1987 Oct;144(10):1306–1309. [PubMed]
  • Grace AA. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience. 1991;41(1):1–24. [PubMed]
  • Ho BC, Andreasen NC, Flaum M, Nopoulos P, Miller D. Untreated initial psychosis: its relation to quality of life and symptom remission in first-episode schizophrenia. Am J Psychiatry. 2000 May;157(5):808–815. [PubMed]
  • McGlashan TH. The prediction of outcome in chronic schizophrenia. IV. The Chestnut Lodge follow-up study. Arch Gen Psychiatry. 1986 Feb;43(2):167–176. [PubMed]
  • McGlashan TH, Johannessen JO. Early detection and intervention with schizophrenia: rationale. Schizophr Bull. 1996;22(2):201–222. [PubMed]
  • McGorry PD, Edwards J, Mihalopoulos C, Harrigan SM, Jackson HJ. EPPIC: an evolving system of early detection and optimal management. Schizophr Bull. 1996;22(2):305–326. [PubMed]
  • Norman RM, Malla AK. Duration of untreated psychosis: a critical examination of the concept and its importance. Psychol Med. 2001 Apr;31(3):381–400. [PubMed]
  • Lieberman JA, Koreen AR, Chakos M, Sheitman B, Woerner M, Alvir JM, Bilder R. Factors influencing treatment response and outcome of first-episode schizophrenia: implications for understanding the pathophysiology of schizophrenia. J Clin Psychiatry. 1996;57 (Suppl 9):5–9. [PubMed]
  • Lo WH, Lo T. A ten-year follow-up study of Chinese schizophrenics in Hong Kong. Br J Psychiatry. 1977 Jul;131:63–66. [PubMed]
  • Loebel AD, Lieberman JA, Alvir JM, Mayerhoff DI, Geisler SH, Szymanski SR. Duration of psychosis and outcome in first-episode schizophrenia. Am J Psychiatry. 1992 Sep;149(9):1183–1188. [PubMed]
  • Robinson DG, Woerner MG, Alvir JM, Geisler S, Koreen A, Sheitman B, Chakos M, Mayerhoff D, Bilder R, Goldman R, et al. Predictors of treatment response from a first episode of schizophrenia or schizoaffective disorder. Am J Psychiatry. 1999 Apr;156(4):544–549. [PubMed]
  • Szymanski SR, Cannon TD, Gallacher F, Erwin RJ, Gur RE. Course of treatment response in first-episode and chronic schizophrenia. Am J Psychiatry. 1996 Apr;153(4):519–525. [PubMed]
  • Wyatt RJ. Neuroleptics and the natural course of schizophrenia. Schizophr Bull. 1991;17(2):325–351. [PubMed]

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