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Indian J Psychiatry. 2003 Apr-Jun; 45(2): 31–38.
PMCID: PMC2952144

Psychopathology in children of schizophrenics


The higher prevalence of schizophrenia in children of schizophrenics than in the general population has generated an interest in pinpointing those behaviors that may precede the disorder and serve as an index of vulnerability to the disorder. Signs of neurobehavioral dysfunction in areas of neurocognitive functioning and social behavior have been found in school-age children of schizophrenic parents. This study assessed the neurobehavioral functioning, social behavior, cognitive functioning, attention and intelligence in children with a schizophrenic parent and compared the same parameters with children of mentally healthy parents. The children aged 12-15 years, were assessed with a battery of neurobehavioral tests. The children with a schizophrenic parent performed more poorly on the tests as compared to the children of mentally healthy parents. The children with a schizophrenic parent were seen to have more behavioral problems, especially withdrawn behavior and more social problems when compared to the other children in the study. Poor attention, disordered thoughts and lower intelligence were also observed to be more in the children of the schizophrenic parent

Keywords: Children, schizophrenic parents, intelligence, attention, thought disorder

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Selected References

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  • Arbelle S, Magharious W, Auerbach JG, Hans SL, Marcus J, Styr B, Caplan R. Formal thought disorder in offspring of schizophrenic parents. Isr J Psychiatry Relat Sci. 1997;34(3):210–221. [PubMed]
  • Arboleda C, Holzman PS. Thought disorder in children at risk for psychosis. Arch Gen Psychiatry. 1985 Oct;42(10):1004–1013. [PubMed]
  • Auerbach JG, Hans S, Marcus J. Neurobehavioral functioning and social behavior of children at risk for schizophrenia. Isr J Psychiatry Relat Sci. 1993;30(1):40–49. [PubMed]
  • Asarnow RF, Steffy RA, MacCrimmon DJ, Cleghorn JM. An attentional assessment of foster children at risk for schizophrenia. J Abnorm Psychol. 1977 Jun;86(3):267–275. [PubMed]
  • Asarnow JR. Children at risk for schizophrenia: converging lines of evidence. Schizophr Bull. 1988;14(4):613–631. [PubMed]
  • Aylward E, Walker E, Bettes B. Intelligence in schizophrenia: meta-analysis of the research. Schizophr Bull. 1984;10(3):430–459. [PubMed]
  • Baum KM, Walker EF. Childhood behavioral precursors of adult symptom dimensions in schizophrenia. Schizophr Res. 1995 Aug 1;16(2):111–120. [PubMed]
  • Bennedsen BE. Adverse pregnancy outcome in schizophrenic women: occurrence and risk factors. Schizophr Res. 1998 Sep 7;33(1-2):1–26. [PubMed]
  • Beisser AR, Glasser N, Grant M. Psychosocial adjustment in children of schizophrenic mothers. J Nerv Ment Dis. 1967 Dec;145(6):429–440. [PubMed]
  • Cannon M, Jones P, Gilvarry C, Rifkin L, McKenzie K, Foerster A, Murray RM. Premorbid social functioning in schizophrenia and bipolar disorder: similarities and differences. Am J Psychiatry. 1997 Nov;154(11):1544–1550. [PubMed]
  • Done DJ, Crow TJ, Johnstone EC, Sacker A. Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11. BMJ. 1994 Sep 17;309(6956):699–703. [PMC free article] [PubMed]
  • Dworkin RH, Lewis JA, Cornblatt BA, Erlenmeyer-Kimling L. Social competence deficits in adolescents at risk for schizophrenia. J Nerv Ment Dis. 1994 Feb;182(2):103–108. [PubMed]
  • Dworkin RH, Green SR, Small NE, Warner ML, Cornblatt BA, Erlenmeyer-Kimling L. Positive and negative symptoms and social competence in adolescents at risk for schizophrenia and affective disorder. Am J Psychiatry. 1990 Sep;147(9):1234–1236. [PubMed]
  • Erlenmeyer-Kimling L, Cornblatt B. Attentional measures in a study of children at high-risk for schizophrenia. J Psychiatr Res. 1978;14(1-4):93–98. [PubMed]
  • Erlenmeyer-Kimling L, Cornblatt B. Biobehavioral risk factors in children of schizophrenic parents. J Autism Dev Disord. 1984 Dec;14(4):357–374. [PubMed]
  • Erlenmeyer-Kimling L, Cornblatt B. High-risk research in schizophrenia: a summary of what has been learned. J Psychiatr Res. 1987;21(4):401–411. [PubMed]
  • Fish B. Infant predictors of the longitudinal course of schizophrenic development. Schizophr Bull. 1987;13(3):395–409. [PubMed]
  • Gamer E, Gallant D, Grunebaum HU, Cohler BJ. Children of psychotic mothers. Performance of 3-year-old children on tests of attention. Arch Gen Psychiatry. 1977 May;34(5):592–597. [PubMed]
  • Grunebaum H, Weiss JL, Gallant D, Cohler BJ. Attention in young children of psychotic mothers. Am J Psychiatry. 1974 Aug;131(8):887–891. [PubMed]
  • Hans SL, Marcus J, Henson L, Auerbach JG, Mirsky AF. Interpersonal behavior of children at risk for schizophrenia. Psychiatry. 1992 Nov;55(4):314–335. [PubMed]
  • Herman J, Mirsky AF, Ricks NL, Gallant D. Behavioral and electrographic measures of attention in children at risk for schizophrenia. J Abnorm Psychol. 1977 Feb;86(1):27–33. [PubMed]
  • John K, Gammon GD, Prusoff BA, Warner V. The Social Adjustment Inventory for Children and Adolescents (SAICA): testing of a new semistructured interview. J Am Acad Child Adolesc Psychiatry. 1987 Nov;26(6):898–911. [PubMed]
  • Jones P, Rodgers B, Murray R, Marmot M. Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet. 1994 Nov 19;344(8934):1398–1402. [PubMed]
  • Lifshitz M, Kugelmass S, Karov M. Perceptual-motor and memory performance of high-risk children. Schizophr Bull. 1985;11(1):74–84. [PubMed]
  • Marcus J, Hans SL, Auerbach JG, Auerbach AG. Children at risk for schizophrenia: the Jerusalem Infant Development Study. II. Neurobehavioral deficits at school age. Arch Gen Psychiatry. 1993 Oct;50(10):797–809. [PubMed]
  • Mirsky AF, Anthony BJ, Duncan CC, Ahearn MB, Kellam SG. Analysis of the elements of attention: a neuropsychological approach. Neuropsychol Rev. 1991 Jun;2(2):109–145. [PubMed]
  • Mirsky AF, Kugelmass S, Ingraham LJ, Frenkel E, Nathan M. Overview and summary: twenty-five-year followup of high-risk children. Schizophr Bull. 1995;21(2):227–239. [PubMed]
  • Nuechterlein KH. Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. J Abnorm Psychol. 1983 Feb;92(1):4–28. [PubMed]
  • Nuechterlein KH, Dawson ME. Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schizophr Bull. 1984;10(2):160–203. [PubMed]
  • Rieder RO, Nichols PL. Offspring of schizophrenics. III. Hyperactivity and neurological soft signs. Arch Gen Psychiatry. 1979 Jun;36(6):665–674. [PubMed]
  • Rochester SR, Martin JR, Thurston S. Thought-process disorder in schizophrenia: the listener's task. Brain Lang. 1977 Jan;4(1):95–114. [PubMed]
  • Rolf JE. The social and academic competence of children vulnerable to schizophrenia and other behavior pathologies. J Abnorm Psychol. 1972 Dec;80(3):225–243. [PubMed]
  • Rutschmann J, Cornblatt B, Erlenmeyer-Kimling L. Sustained attention in children at risk for schizophrenia: findings with two visual continuous performance tests in a new sample. J Abnorm Child Psychol. 1986 Sep;14(3):365–385. [PubMed]
  • Sacker A, Done DJ, Crow TJ. Obstetric complications in children born to parents with schizophrenia: a meta-analysis of case-control studies. Psychol Med. 1996 Mar;26(2):279–287. [PubMed]
  • Sameroff AJ, Seifer R. Familial risk and child competence. Child Dev. 1983 Oct;54(5):1254–1268. [PubMed]
  • Schreiber H, Stolz-Born G, Heinrich H, Kornhuber HH, Born J. Attention, cognition, and motor perseveration in adolescents at genetic risk for schizophrenia and control subjects. Psychiatry Res. 1992 Nov;44(2):125–140. [PubMed]
  • Schulsinger H. A ten-year follow-up of children of schizophrenic mothers. Clinical assessment. Acta Psychiatr Scand. 1976 May;53(5):371–386. [PubMed]
  • Silverton L, Harrington ME, Mednick SA. Motor impairment and antisocial behavior in adolescent males at high risk for schizophrenia. J Abnorm Child Psychol. 1988 Apr;16(2):177–186. [PubMed]
  • Sohlberg SC. Personality and neuropsychological performance of high-risk children. Schizophr Bull. 1985;11(1):48–60. [PubMed]
  • Sohlberg SC, Yaniv S. Social adjustment and cognitive performance of high-risk children. Schizophr Bull. 1985;11(1):61–65. [PubMed]
  • Watt NF, Grubb TW, Erlenmeyer-Kimling L. Social, emotional, and intellectual behavior at school among children at high risk for schizophrenia. J Consult Clin Psychol. 1982 Apr;50(2):171–181. [PubMed]
  • Weintraub S, Neale JM, Leibert DE. Teacher ratings of children vulnerable to psychopathology. Am J Orthopsychiatry. 1975 Oct;45(5):838–845. [PubMed]

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