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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Int J Pediatr Obes. Author manuscript; available in PMC 2010 October 8.
Published in final edited form as:
Int J Pediatr Obes. 2010 August; 5(4): 305–312.
doi:  10.3109/17477160903497027
PMCID: PMC2951976

Artificial Sweeteners: A systematic review of metabolic effects in youth


Epidemiological data have demonstrated an association between artificial sweetener use and weight gain. Evidence of a causal relationship linking artificial sweetener use to weight gain and other metabolic health effects is limited. However, recent animal studies provide intriguing information that supports an active metabolic role of artificial sweeteners. This systematic review examines the current literature on artificial sweetener consumption in children and its health effects. Eighteen studies were identified. Data from large, epidemiologic studies support the existence of an association between artificially-sweetened beverage consumption and weight gain in children. Randomized controlled trials in children are very limited, and do not clearly demonstrate either beneficial or adverse metabolic effects of artificial sweeteners. Presently, there is no strong clinical evidence for causality regarding artificial sweetener use and metabolic health effects, but it is important to examine possible contributions of these common food additives to the global rise in pediatric obesity and diabetes.

Keywords: Acesulfame-K, artificial sweetener, aspartame, neotame, obesity, saccharine, sucralose, weight gain


Artificial sweeteners and the obesity epidemic

As a means to help curtail the obesity epidemic, small dietary changes to prevent weight gain in children and adolescents have been encouraged (1). Artificial sweeteners have gained attention as dietary tools (2) that provide sweet taste without the extra energy derived from foods and drinks containing caloric sugars (37), and thus may assist in weight-loss plan adherence (8). A key question is whether replacement of sugar-sweetened products with those containing artificial sweeteners is truly beneficial.

Since their FDA approval, artificial sweeteners and their benefits on metabolic health have been questioned (9,10). An association between artificial sweetener intake and weight gain was first observed in epidemiological studies with adults. Several largescale studies, including the National Health and Nutrition Examination Survey (NHANES) and the San Antonio Heart Study, have shown a positive association between artificial sweetener use and increases in weight and/or BMI (1114). Other large, prospective cohort studies in adults have shown associations between artificial sweetener intake and incidence of the metabolic syndrome and its components, including waist circumference, blood pressure, and fasting blood glucose (1518). Some studies in adults have demonstrated links between artificial sweetener consumption and insulin resistance, incidence of type 2 diabetes, and poor glucose control in patients with pre-existing diabetes (19,20), while others have found no association with diabetes incidence or glycemia control (21,22).

Beneficial effects of artificial sweeteners have been shown in adults, as well. For example, the Nurses Health Study II found decreased weight gain among adults who consumed artificially-sweetened beverages (23). More importantly, randomized controlled studies in adults have shown mildly beneficial results of artificial sweetener use, including decreased weight regain after dieting (24), and weight-stability or minimal short-term weight loss compared with caloric-sweetener supplementation (25,26). In response to these conflicting data, several reviews were conducted (27,28). The consensus in the early 1990s was that artificial sweeteners had not been found to increase weight in humans (29,30).

Mechanism of action of artificial sweeteners

Multiple behavioral mechanisms have been proposed to account for the epidemiologic association between artificial sweetener use and weight gain. It has been suggested that the dissociation of the sensation of sweet taste from caloric intake may promote appetite, leading to greater food consumption and weight gain. In addition, increased consumption of added caloric sweeteners has been associated with lower diet quality in children (31), perhaps by altering taste preferences toward sweetened foods in place of more healthful foods, such as fruits and vegetables; this mechanism could apply to artificial sweeteners as well.

New data from both humans and animal models have provided convincing evidence that artificial sweeteners play an active role in the gastrointestinal tract, thus providing a mechanistic explanation for observed metabolic effects. Sweet-taste receptors, including the taste receptor T1R family and α-gustducin, respond not only to caloric sugars, such as sucrose and glucose, but also to artificial sweeteners, including sucralose (Splenda™) and acesulfame-K (32,33). In both humans and animals, these receptors have been shown to be present not only in lingual taste buds, but also in glucagon-like peptide-1 (GLP-1) secreting L cells of the gut mucosa (3436), where they serve as critical mediators of GLP-1 secretion (36). Mace et al. showed in rat studies that stimulation of intestinal taste receptors with sucralose led to more rapid absorption of sugars from the intestine into the bloodstream (32). We have demonstrated in young healthy volunteers that consumption of diet soda before an oral glucose challenge potentiates GLP-1 secretion, thus potentially altering both gastric emptying and insulin secretion (62). Translating these results into the clinical realm, consumption of an artificial sweetener in conjunction with a sugarcontaining food or drink could lead to more rapid sugar absorption, as well as increased GLP-1 and insulin secretion, potentially affecting weight, appetite, and glycemia.

In light of this new information regarding the metabolic activity of artificial sweeteners, we have conducted a systematic review of the effects of artificial sweeteners on food intake, weight, and metabolic health in children.

Commonly used artificial sweeteners

Currently, the FDA has approved five artificial sweeteners for consumption: acesulfame-K, aspartame, neotame, saccharin, and sucralose (Table I). In addition, the FDA has determined that a new sugar substitute, stevia, is a dietary supplement “generally recognized as safe” (GRAS). Artificial sweeteners are known by several names, which include: low-calorie sweeteners, high intensity sweeteners, non-sucrose sweeteners, intense sweeteners, non-nutritive sweeteners, sugar substitutes, and sugar-free sweeteners (37). For the purposes of this review, we will use the term “artificial sweeteners.”

Table I
FDA-approved artificial sweeteners.

Artificial sweetener intake in children

Beverages have been identified as a major source of artificial sweeteners in the diet (38,39), hence estimates of artificial sweetener consumption are typically based on artificially-sweetened drinks or sodas. Nationally representative surveys from the 1990s estimated that artificially-sweetened sodas accounted for approximately 4–18% of total carbonated beverage intake in children (40,41). Artificially-sweetened soft drink consumption appears to be increasing in children, both with age and over time (4043).


Search strategy

Eligible studies were identified by searching the following electronic databases: PubMed, Web of Science, and EMBASE. The following terms were used: artificial sweeteners, sweetening agent, sweetener, sugar substitute, nonnutritive sweetener, intense sweetener, sucralose, aspartame, saccharin, sugar free, diabetes, weight, obesity, obese, metabolic syndrome, cholesterol, and blood pressure. The year of publication was not restricted. Additional studies were identified by manual search of reference lists of key original and review articles.

Study selection

For inclusion, studies were required to: (a) be published in peer reviewed journals in the English language, (b) include pediatric subjects age 0 to 18; (c) specifically address artificial sweetener consumption in association with metabolic health effects, such as food intake, weight change, diabetes, and metabolic syndrome components; and (d) provide original data. Articles published solely in abstract form were omitted.

Data extraction

Two authors (RJB and MAdB) independently identified potentially relevant articles based on titles and abstracts. A full text record was retrieved when articles met eligibility criteria or when reviewers disagreed. A third reviewer (KIR) with no involvement in the initial search process resolved disagreements.

Data extracted from eligible articles included author, date and duration of study, study design, characteristics of the participants (sample size, age, gender), outcome measures and results.


The initial literature search produced 116 potentially eligible articles. Of these articles, 111 were excluded as they did not meet requirements. An additional 13 articles were identified based on a reference list search of review articles. Our search yielded a total of 18 human studies, summarized in Table II.

Table II
Review of pediatric studies on the effects of artificial sweeteners on weight gain and glucose metabolism.

Effects of artificial sweeteners on food intake in children

Several studies have looked at the effect of caloric versus artificial sweetener preloads on subsequent ad libitum food intake in children. In two experiments, boys aged 9–14 with a wide range of body mass indices (BMIs) exhibited complete caloric compensation in ad libitum lunch intake 30 minutes following a sucralose versus sugar-sweetened drink, meaning that they reduced their intake at lunch by the number of calories contained in the preload (44,45). In another study, 2.5 to 5-year-old children showed complete caloric compensation 20 minutes after a low-calorie, aspartame-sweetened pudding preload versus high-calorie, maltodextrin-sweetened pudding (46). Interestingly, adults participating in the same experiment showed no caloric compensation, meaning they ate the same number of calories at lunch regardless of which preload they received.

The timing of artificial sweetener consumption with respect to meals may also affect food intake. Children who consumed sugar-sweetened beverages immediately prior to a test meal ate less than those who consumed artificially-sweetened beverages before the meal (47). However, no compensation in meal intake was observed when sugar- versus artificially-sweetened beverages were given 30, 60, or 90 minutes prior to the test meal (47,48). In addition, children reduced ad libitum lunch intake 30 minutes after an aspartame-sweetened preload (compared with water), but not after 0 or 60 minutes (47).

These studies, of course, do not describe the effect of chronic consumption of artificial sweeteners on food intake. Birch et al. explored this idea by giving 3 to 5-year-old children an ad libitum snack 20 minafter either low-calorie (aspartame-sweetened) or high-calorie (maltodextrin-sweetened) pudding during multiple trials (49). With each trial, children consistently showed complete caloric compensation for the preload. However, when subsequently given an intermediate caloric density pudding of the same flavor they had received previously, children who had eaten low-calorie pudding beforehand ate significantly more snack than those previously given high-calorie pudding, by approximately 50 kcal.

Observational studies of artificial sweeteners and weight gain in children

The majority of pediatric epidemiologic studies have found a positive correlation between weight gain and artificially-sweetened beverage intake. Blum et al. examined beverage consumption and BMI Z-scores in 164 elementary school-aged children (43). This longitudinal study found that increased diet soda consumption was positively correlated with follow-up BMI Z-score after two years. Comparable results were found by Berkey et al., who examined the relationship between BMI and diet soda consumption in over 10 000 children (aged 9 to 14 years) of Nurses' Health Study II participants over the course of one year (50). Artificially-sweetened beverage intake was significantly correlated with weight gain in boys, but not in girls, during the study period. A long-term prospective study of 1 203 children in England found that artificially-sweetened beverage consumption at ages 5 and 7 was correlated both with baseline BMI and fat mass at age 9 (51). Another longitudinal study of 2 371 girls (aged 9 and 10) participating in the National Heart, Lung and Blood Institute Growth and Health Study showed that diet soda consumption was significantly associated with higher daily caloric intake, but not with BMI (41). A much smaller study of 177 children aged 3 to 6 years showed no association between diet soda consumption and risk of obesity (42).

Several cross-sectional studies in children have added to the association between artificially-sweetened beverage use and adverse health effects. Forshee et al. analyzed data from the US Department of Agriculture's Continuing Survey of Food Intake by Individuals from 1994–96 and 1998. This nationally representative sample of US children between 6 and 19 years of age found that BMI was positively correlated with diet soda consumption (52). These results were consistent with Giammattei et al.'s findings in 385 sixth and seventh graders, which showed that both diet and sugar-sweetened soda intake were positively correlated with BMI z-score and percent body fat (53). However, a study of 2 to 5-year-old children using NHANES data did not show an association between artificially-sweetened beverage consumption and BMI in this age group (54).

To date, only one observational study has shown an inverse association between artificial sweetener use and weight gain. In this study of 548 ethnically diverse school children (mean age 11.7 years) in Massachusetts, Ludwig et al. found that increased diet soda consumption over a 19-month time period was associated with decreased incidence of obesity, whereas the odds ratio of becoming obese increased 1.6 fold for each sugar-sweetened drink consumed (55).

Interventional studies of artificial sweeteners and weight gain in children

Three small interventional studies that manipulated artificial sweetener intake have been conducted in children, and have failed to show metabolic effects. Shortly after the approval of aspartame by the FDA, its effects during active weight reduction and its role in glucoregulatory hormone changes were studied in 55 overweight children and young adults, aged 10 to 21, during a 13-week 1 000 kcal/day diet (56). There were no differences in weight loss for subjects receiving 2.7 g/day of encapsulated aspartame versus placebo.

A randomized, controlled pilot study of 103 adolescents, aged 13 to 18 years, examined the effect of replacing sugar-sweetened drinks with artificially-sweetened beverages or water during a 25-week period (57). Changes in BMI for intervention versus control (no replacement of sugar-sweetened drinks) were not significant for the entire group, although an exploratory post-hoc analysis showed that the intervention made the greatest difference in the heaviest subjects, whose BMIs declined by 0.63 ± 0.23 kg/m2, compared with a 0.12 ± 0.26 kg/m2 gain in the control group. However, the authors did not separately report consumption of water versus artificially-sweetened beverages during the intervention, and thus the effect of artificial sweeteners in this study could not be isolated.

In the third randomized, controlled trial, girls aged 11 to 15 years consumed a 1500 kcal/day diet for 12 weeks. In one group, sugar-sweetened soda was permitted as a snack, while in the other group, only diet sodas were permitted. There were no differences between groups for BMI change, and reported intake of either sugar-sweetened or artificially-sweetened soda did not affect BMI change (3).

Artificial sweeteners and the metabolic syndrome

Components of the metabolic syndrome have been assessed in two pediatric studies. The previously discussed study of encapsulated aspartame versus placebo in young people found no differences in blood pressure, glucose, or lipid profiles between groups (56). Similarly, in the study in which teenage girls were permitted either sugar-sweetened or artificially-sweetened soda as a snack during weight loss, there were no differences between groups in blood pressure, waist circumference, or lipid profile (3).


Recent epidemiological, clinical and laboratory findings question whether recommendations for the use of artificial sweeteners are indeed appropriate. A careful review of this literature by health professionals including physicians, epidemiologists, and dietitians is necessary to help consumers make well-informed decisions about their health. In this review, we have examined the existing evidence supporting or refuting a link between artificial sweetener use and weight change and other metabolic effects in children.

Epidemiologic studies of artificial sweetener use in children have generally shown a positive association between artificial sweetener intake (most commonly as diet soda) and weight gain. In interpreting such studies, it is critical to consider the conditions required to support causality in such studies, including the strength of the association, consistency in findings, temporality, biological gradient, plausibility, coherence between epidemiological and laboratory findings, and strength of the dose-response relationship (58). Based on these criteria, causality is far from established with regard to artificial sweetener use and weight gain in children. It is particularly difficult to establish causality between artificial sweetener consumption, weight gain, and metabolic abnormalities, as artificial sweetener intake is likely to be an indicator for other variables. For example, the decision to consume artificial sweeteners is often made by individuals who are concerned about their weight in an effort to reduce their caloric intake. In the case of children, this decision is frequently made by parents who are concerned about their own weight and consequently the weight of their offspring, thus further confounding the choice to use artificial sweeteners with genetic and behavioral variables.

Studies of artificial sweeteners and food intake demonstrate that caloric compensation is more complete in children than in adults, in whom food intake is substantially influenced by social cues and learned behaviors. However, even in children the degree of caloric compensation depends on the timing of the preload relative to the ad libitum meal, as well as the age of the child and other experimental circumstances. Although not all studies agree, the general trend is that artificial sweeteners may reduce total caloric intake when consumed between meals, but when consumed with meals, children may compensate for low-calorie snacks or drinks by increasing meal-associated calories. One study (49) supported the hypothesis that training children to associate sweet taste with low caloric density may result in overeating. Such studies, while not realistically mimicking actual human behavior, may provide insight into underlying mechanisms.

The strongest evidence for causation between artificial sweetener use and either adverse or beneficial health effects comes from randomized controlled trials. The few small, randomized controlled trials conducted in children did not find an association between artificial sweetener consumption and weight change. However, these studies were not specifically designed to look for effects of artificial sweeteners on weight change, and were presumably underpowered to find such effects. Currently, several trials are in progress to study the effects of artificially-sweetened carbonated soft drinks on body weight and other metabolic parameters in both children and adults (59,60), and studies of mechanisms underlying metabolic effects of artificial sweeteners are ongoing as well (61). These studies, and other similar investigations, will be critical for advancing understanding of the role of artificial sweeteners in metabolic health.

At the current time, the jury remains out regarding a possible role of increased artificial sweetener use in the obesity and diabetes epidemics, whether adverse, beneficial or neutral. In particular, very little data exist regarding the role of artificial sweeteners in glucose metabolism in children. Our growing understanding of the active metabolic role played by such chemicals in animal models should spur further research into the effects of these common food additives in humans.


This work was supported by the intramural research program of the National Institute of Diabetes, Digestive and Kidney Diseases.


Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.


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