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Indian J Psychiatry. 2004 Oct-Dec; 46(4): 319–323.
PMCID: PMC2950950

Risperidone and Olanzapine Induced Tardive Dyskinesia : A Critical Review of Reported Cases


Risperidone and olanzapine in treatment of psychiatric patients can provoke a plethora of tardive dyskinesias which pose problems for them. This clinical problem requires the urgent attention of mental health professionals. Hence a comprehensive research of Medline and related literature was undertaken from 1996 till August 2004. The published twenty two cases of risperidone (N=12) or olanzapine (N=10) induced tardive dyskinesia were critically reviewed and an attempt is being made to clarify the various issues associated with them. In these reports majority of patients were in younger age group, females and the interval until onset of tardive dyskinesia after initiation of risperidone or olanzapine was within one year. In eight reported cases of risperidone induced and three cases of olanzapine induced tardive dyskinesia, TD disappears either by stopping the drug or switching to other atypical antipsychotic drug. In seven cases of risperidone induced and three cases of olanzapine induced tardive dyskinesia, there was previous exposure to conventional antipsychotic drugs. It is concluded that induction of tardive dyskinesia by these medications is insufficiently documented in these reports but in some cases evidence is suggestive of the role of these drugs in development of tardive dyskinesia. There is no generally accepted treatment for tardive dyskinesia, thus long term studies with risperidone and olanzapine are needed in future to ascertain their tardive dyskinesia liability. Mental health professionals must remain vigilant about onset of tardive dyskinesia with these medications.

Keywords: Risperidone, olanzapine, tardive dyskinesia

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Selected References

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  • Ananth J, Kenan J. Tardive dyskinesia associated with olanzapine monotherapy. J Clin Psychiatry. 1999 Dec;60(12):870–870. [PubMed]
  • Benazzi Franco. Rapid onset of tardive dyskinesia in Huntington disease with olanzapine. J Clin Psychopharmacol. 2002 Aug;22(4):438–439. [PubMed]
  • Bella VL, Piccoli F. Olanzepine-induced tardive dyskinesia. Br J Psychiatry. 2003 Jan;182:81–82. [PubMed]
  • Bhanji Nadeem H, Margolese Howard C. Tardive dyskinesia associated with olanzapine in a neuroleptic-naive patient with schizophrenia. Can J Psychiatry. 2004 May;49(5):343–343. [PubMed]
  • Buzan RD. Risperidone-induced tardive dyskinesia. Am J Psychiatry. 1996 May;153(5):734–735. [PubMed]
  • Casey Daniel E. Pathophysiology of antipsychotic drug-induced movement disorders. J Clin Psychiatry. 2004;65 (Suppl 9):25–28. [PubMed]
  • Daniel DG, Smith K, Hyde T, Egan M. Neuroleptic-induced tardive dyskinesia. Am J Psychiatry. 1996 May;153(5):734–734. [PubMed]
  • Dubbelman YD, Thung FH, Heeringa M. Ernstige tardieve dyskinesieën tijdens behandeling met risperidon en fluoxetine. Ned Tijdschr Geneeskd. 1998 Jun 27;142(26):1508–1511. [PubMed]
  • Dunayevich E, Strakowski SM. Olanzapine-induced tardive dystonia. Am J Psychiatry. 1999 Oct;156(10):1662–1662. [PubMed]
  • Ghelber D, Belmaker RH. Tardive dyskinesia with quetiapine. Am J Psychiatry. 1999 May;156(5):796–797. [PubMed]
  • Gunal DI, Onultan O, Afsar N, Aktan S. Tardive dystonia associated with olanzapine therapy. Neurol Sci. 2001 Aug;22(4):331–332. [PubMed]
  • Hansen TE, Brown WL, Weigel RM, Casey DE. Underrecognition of tardive dyskinesia and drug-induced parkinsonism by psychiatric residents. Gen Hosp Psychiatry. 1992 Sep;14(5):340–344. [PubMed]
  • Jaffe ME, Simpson GM. Reduction of tardive dystonia with olanzapine. Am J Psychiatry. 1999 Dec;156(12):2016–2016. [PubMed]
  • Koch HJ, Szecsey A, Vogel M, Fischer-Barnicol D. Successful therapy of tardive dyskinesia in a 71-year-old woman with a combination of tetrabenazine, olanzapine and tiapride. Int J Clin Pract. 2003 Mar;57(2):147–149. [PubMed]
  • Kumar S, Malone DM. Risperidone implicated in the onset of tardive dyskinesia in a young woman. Postgrad Med J. 2000 May;76(895):316–317. [PMC free article] [PubMed]
  • Kumet Richard, Freeman Marlene P. Clozapine and tardive dyskinesia. J Clin Psychiatry. 2002 Feb;63(2):167–168. [PubMed]
  • Hong KS, Cheong SS, Woo JM, Kim E. Risperidone-induced tardive dyskinesia. Am J Psychiatry. 1999 Aug;156(8):1290–1290. [PubMed]
  • Saran BM. Risperidone-induced tardive dyskinesia. J Clin Psychiatry. 1998 Jan;59(1):29–30. [PubMed]
  • Llorca Pierre-Michel, Chereau Isabelle, Bayle Frank-Jean, Lancon Christophe. Tardive dyskinesias and antipsychotics: a review. Eur Psychiatry. 2002 May;17(3):129–138. [PubMed]
  • Simpson GM. The treatment of tardive dyskinesia and tardive dystonia. J Clin Psychiatry. 2000;61 (Suppl 4):39–44. [PubMed]
  • Snoddgrass PL, Labbate LA. Tardive dyskinesia from risperidone and olanzapine in an alcoholic man. Can J Psychiatry. 1999 Nov;44(9):921–921. [PubMed]
  • Suzuki Eiji, Obata Michiyuki, Yoshida Yoshiko, Miyaoka Hitoshi. Tardive dyskinesia with risperidone and anticholinergics. Am J Psychiatry. 2002 Nov;159(11):1948–1948. [PubMed]
  • Tamminga CA, Thaker GK, Moran M, Kakigi T, Gao XM. Clozapine in tardive dyskinesia: observations from human and animal model studies. J Clin Psychiatry. 1994 Sep;55 (Suppl B):102–106. [PubMed]
  • Woerner MG, Sheitman BB, Lieberman JA, Kane JM. Tardive dyskinesia induced by risperidone? Am J Psychiatry. 1996 Jun;153(6):843–843. [PubMed]

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