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Logo of jcinvestThe Journal of Clinical Investigation
[Cover image of issue]

The toll of autoimmunity

Spleen section showing a rim of B220+ (green) B cells peripheral to the MOMA-1+ (red) macrophages. Demaria and colleagues use two new murine models to demonstrate a role for TLR8 in the regulation of TLR7 expression and prevention of spontaneous autoimmunity (page 3651). Tlr8–/– spleens showed a reduction of B cells despite a normal follicular architecture

J Clin Invest. 2010 October 1; 120(10): Cover