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J Glob Infect Dis. 2010 Sep-Dec; 2(3): 312.
PMCID: PMC2946693

A Cross-Sectional Study Among Medical Residents with Noninvasive Rapid Serological Test for Helicobacter Pylori


Helicobacter pylori infection is causally associated with peptic ulcer disease and gastric carcinoma. The goal of this study was to determine the seroprevalence rate of Helicobacter pylori (Hp) antibodies in residents, and its relationship with dyspepsia. This cross-sectional study was carried out in September 2009 on a population of 55 residents who were willing to participate in this study at Meenakshi Medical College. The study was carried out after obtaining proper approval from the ethical committee. Each participant was interviewed using a questionnaire.

Rapid serological test for H. pylori antibody (ACCUC80305503/2010) using immunochromatography was carried out. The kit has >99% sensitivity, 86.7% specificity, 93.2% accuracy and 95% confidence intervals. After obtaining informed consent, 3 mL of venous blood was taken from the medical students for serological rapid test for H. pylori.

In this cross-sectional study, only 55 students could be screened for H. pylori serology. There were 18 (32.72%) male and 37 (67.27%) female students with or without specific gastrointestinal signs and symptoms, like heartburn, regurgitation, abdominal pain, vomiting and hemetemesis/ melena, of whom 10 (18.18%) were positive for H. pylori IgG antibodies. The age of the participants was between 21 and 23 years, and the mean age was 22. At the end of this study, 6 (10.91%) males and 4 (7.27%) females were positive for H. pylori IgG tests (ACCUC803055). Finally, the H. pylori positivity rate was 33.33% (6/18) among males and 10.81% (4/37) among females. Of the 21 (38.18%) participants reporting dyspeptic symptoms, 4 (2 males, 2 females) (19%) were Hp positive. Of the 34 asymptomatic students, 6 (4 males, 2 females) (17.64%) were Hp positive. Statistical analysis did not show a significant difference in the frequency of Hp infection between asymptomatic students and students reporting dyspeptic symptoms.

This study should be followed by a large-scale study with multicentric screening to validate the results, as the sample size of this study was small because of the unwillingness of the medical students to participate and cost constraints.

According to the study, the prevalence rate was 18.88% for H. pylori in residents, which is comparatively low than that reported in a Brazil study by Melo ET et al,[1] in which 38.4% positivity was observed. The male group of medical students showed high positivity rate, viz., 33.33%, probably due to unhealthy life style, like frequent intake of spicy food, irregular diet and inadequate sleep. There was no significant difference in Hp prevalence between dyspeptic students and asymptomatic students.[2] Hence it can be concluded that according to this study, the H. pylori infection is common in males and does not have significant relationship with dyspepsia.


I would like to thank Ms. Bhuvaneswari, Statistician, Community medicine department for her valuable help in statistical analysis.


1. Melo ET, Lopes EP, Almeida JR, Albuquerque MF, Moura IM. Seroprevalence of Helicobacter pylori antibodies in medical students and residents in Recife, Brazil. J Clin Gastroenterol. 2003;36:134–8. [PubMed]
2. Hoffmann KM, Eherer AJ, Krejs GJ. Hoffmann KM, Eherer AJ, Krejs GJ. Are dyspeptic symptoms linked to Helicobacter pylori? A prospective cohort study among medical students. Wien Klin Wochenschr. 2003;115:175–8. [PubMed]

Articles from Journal of Global Infectious Diseases are provided here courtesy of Wolters Kluwer -- Medknow Publications