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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
J Neuropathol Exp Neurol. Author manuscript; available in PMC 2010 September 24.
Published in final edited form as:
J Neuropathol Exp Neurol. 2009 July; 68(7): 709–735.
doi: 10.1097/NEN.0b013e3181a9d503

Figure 2

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(A–C) Whole mount 50-μm coronal sections of superior frontal cortex from case 1 (A), case 2 (B), case 3 (C) immunostained for tau with monoclonal antibody CP-13 showing extensive immunoreactivity that is greatest at sulcal depths (asterisks) and is associated with contraction of the cortical ribbon. (D–F) Microscopically there are dense tau-immunoreactive neurofibrillary tangles (NFTs) and neuropil neurites throughout the cortex, case 1 (D), case 2 (E) and case 3 (F). There are focal nests of NFTs and astrocytic tangles around small blood vessels (E, arrow) and plaque-like clusters of tau-immunoreactive astrocytic processes distributed throughout the cortical layers (F, arrows).

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