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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Aging Cell. Author manuscript; available in PMC 2011 October 1.
Published in final edited form as:
Aging Cell. 2010 October; 9(5): 785–798.
doi: 10.1111/j.1474-9726.2010.00611.x

Figure 2

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The expression of activation markers and costimulatory molecules on splenic PD-1+ T cells from aged mice

Single cell suspensions from spleens were stained for the surface markers CD4, CD8, CD25, CD28, CD69, CD127, CTLA-4, ICOS and PD-1 and intracellularly for CTLA-4, and ICOS. Expression of PD-1 versus CD69 on CD4+ and CD8+ T cells from young (3-month old) and aged (16-month old) mice (A). Percentage of cells in PD-1+CD4+ (B) and PD-1+CD8+ (C) T cells expressing the different listed markers are shown. Significance was considered for p values less than 0.05 and indicated with asterisks.

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