PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of ccforumBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleCritical CareJournal Front Page
 
Crit Care. 2010; 14(Suppl 1): P193.
Published online 2010 March 1. doi:  10.1186/cc8425
PMCID: PMC2934413

Adaptive support ventilation may be inappropriate for patients with ALI/ARDS after recruitment: an observational study

Introduction

With adaptive support ventilation (ASV), a microprocessor-controlled mode of mechanical ventilation, the ventilator adapts tidal volume (VT) size based on the Otis least work of breathing formula. In recent studies in patients with ALI/ARDS, ASV applied VT of 7.3 (6.7 to 8.8) ml/kg ideal body weight (IBW). It is unclear whether an open-lung approach was used in these studies. Lung recruitment improves lung compliance, and as a consequence may allow the ventilator to apply too large a VT with ASV.

Methods

Ten consecutive patients with ALI/ARDS, ventilated in accordance with our local protocol dictating frequent recruitment maneuvers, were observed while the ventilator was switched from pressure control ventilation (PC) to ASV. Thereafter, all patients were subjected to an additional standard recruitment procedure. The primary endpoint was VT before and after switch of the ventilator, and after standard recruitment.

Results

Four patients suffered from ALI, six patients from ARDS. Seven patients had an extrapulmonary cause for ALI/ARDS. VT increased from 6.5 ± 0.8 ml/kg IBW to 9.0 ± 1.6 ml/kg IBW (P < 0.01) after switch from PC to ASV. Additional recruitment after switch of the ventilator did not affect VT size (9.3 ± 1.4 ml/kg IBW, P > 0.05). In seven patients ASV applied VT >8 ml/kg IBW, in one patient VT even increased to >12 ml/kg IBW.

Conclusions

Patients with ALI/ARDS may be ventilated with too large a VT when subjected to ASV. Our results contrast findings of previous studies on ASV in patients with ALI/ARDS, probably because we frequently use recruitment maneuvers.


Articles from Critical Care are provided here courtesy of BioMed Central