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Crit Care. 2010; 14(Suppl 1): P294.
Published online 2010 March 1. doi:  10.1186/cc8526
PMCID: PMC2934370

Effect of hyperbaric oxygen on cerebral oxygen saturation in patients with sub-acute traumatic brain injury

L Liu,corresponding author1 B Zhou,1 and B Liu1


How hyperbaric oxygen (HBO) affects injured brain tissue is not yet confirmed. We suppose that HBO could make the oxygen stay longer in the injured tissue, because of poor circulation or perfusion of blood in the injured area. This mechanism may help to explain the longer effect of HBO, after HBO treatment. That is the purpose of our study.


Patients suffering from sub-acute traumatic brain injury, who would be treated with HBO, were enrolled in the study. They were divided into two groups: frontal lobe lesion and nonfrontal lobe lesion groups (n = 20) depending on their iconography check (X-CT or MR). The regional cerebral oxygen saturation (rSO2) was measured by a Somanetics INVOS 5100 monitor before and after 90 minutes treatment with HBO (15 minutes compression, 40 minutes breathing oxygen of FiO2 99% by mask, 10 minutes rest, 15 minutes decompression). Meanwhile, the arterial blood was sampled to measure blood gas analysis and cytokine.


The parameter of rSO2 showed no significant difference following HBO treatment in two groups (t = 0.352, P > 0.05); however, there were inconceivable results in blood gas analysis. Partial pressure of oxygen (PaO2) was significantly decreased after HBO treatment (P < 0.05), although these changes did not take effect on the clinical manifestation. Otherwise, the measurement of cytokines (TNF, IL-1) before and after HBO has no difference (P > 0.05) in all groups.


HBO has no effect on brain oxygen saturation, after HBO treatment. But PaO2 was significantly decreased following HBO. The mechanism needs to be studied further.


  • Allen BW. et al. Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity. J Appl Physiol. 2009;106:662–667. doi: 10.1152/japplphysiol.91109.2008. [PubMed] [Cross Ref]

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