The CREST investigators and committee members were as follows — Principal investigators (in order of decreasing number of patients who were randomly assigned to a treatment group): W. Clark, Oregon Health and Science University, Portland; W. Brooks, Central Baptist Hospital, Lexington, KY; A. Mackey, Centre Hospitalier Affilié Universitaire de Québec–Hôpital de l’Enfant-Jésus, Quebec City, QC, Canada; M. Hill, A. Buchan, University of Calgary–Foothills Medical Centre, Calgary, AB, Canada; P. Leimgruber, Deaconess Medical Center–Northwest Cardiovascular Research Institute, Spokane, WA; V. Mantese, St. John’s Mercy Medical Center, St. Louis; C. Timaran, University of Texas Southwestern Medical School, Dallas; L.N. Hopkins, State University of New York, Buffalo; D. Chiu, Methodist Hospital, Houston; R. Begg, Tri-State Medical Group, Beaver, PA; Z. Jamil, St. Michael’s Medical Center, Newark, NJ; R. Hye, Kaiser Permanente San Diego Medical Center, San Diego, CA; B. Demaerschalk, Mayo Clinic, Scottsdale, AZ; O.W. Brown, Beaumont Hospital, Royal Oak, MI; G.S. Roubin, S. Iyer, Lenox Hill Hospital, New York; D. Heck, Forsyth Medical Center, Winston-Salem, NC; R. Farb, W. Montanera, S.K. Lee, Toronto Western Hospital, Toronto; I. Altafullah, North Memorial Medical Center, Golden Valley, MN; G. Ansel, MidWest Cardiology Research Foundation, Columbus, OH; A. Sam II, Vascular Specialty Associates, Baton Rouge, LA; N. Gonzales, M. Campbell, J. Choi, University of Texas Medical School, Houston; P. Soukas, St. Elizabeth’s Medical Center, Boston; L. Wechsler, University of Pittsburgh Medical Center–Shadyside Hospital and Presbyterian Hospital, Pittsburgh; D. Clair, K. Ouriel, Cleveland Clinic, Cleveland; M. Reisman, W. Gray, Swedish Medical Center, Seattle; J. Eidt, University of Arkansas for Medical Sciences– Central Arkansas Veterans Healthcare System, Little Rock; S. Orlow, Northern Indiana Research Alliance, Fort Wayne; J. Burke, S. Sorenson, P.J. Casterella, Intermountain Medical Center, Salt Lake City; M. Malas, K. Murphy, Johns Hopkins Medical Institutions, Baltimore; M. Rinaldi, Sanger Heart and Vascular Institute, Charlotte, NC; K. Rosenfield, Massachusetts General Hospital, Boston; C. Sternbergh III, R. Felberg, Ochsner Health System, New Orleans; R. McCann, T. Smith, Duke University Medical Center, Durham, NC; C. O’Mara, Mississippi Baptist Medical Center, Jackson; A. Hakaim, Mayo Clinic, Jacksonville, FL; B. Katzen, Baptist Cardiac and Vascular Institute, Miami; R. Spetzler, Barrow Neurological Institute, Phoenix, AZ; A. Pucillo, Westchester Medical Center, Valhalla, NY; J. Elmore, Geisinger Medical Center, Danville, PA; W. Jordan, University of Alabama at Birmingham, Birmingham; D. Lew, Leesburg Regional Medical Center, Leesburg, FL; R. Powell, Dartmouth Hitchcock Medical Center, Lebanon, NH; R. Bulas, the Christ Hospital, Cincinnati; B. Kluck, Lehigh Valley Hospital, Allentown, PA; J. Rapp, San Francisco Veterans Affairs Medical Center, San Francisco; G. Mishkel, Prairie Education and Research Cooperative, Springfield, IL; F. Weaver, University of Southern California, Los Angeles; M. Nazzal, University of Toledo Medical Center, Toledo, OH; C. Narins, University of Rochester Medical Center, Rochester, NY; R. Molnar, Michigan Vascular Research Center, Flint; M. Eskandari, Northwestern Memorial Hospital, Chicago; H. Aronow, Michigan Heart and Vascular Institute, Ann Arbor; F. Shawl, Washington Adventist Hospital, Takoma Park, MD; R. Rosenwasser, Thomas Jefferson University, Philadelphia; H. Chastain, Parkview Research Center, Fort Wayne, IN; M. Foster, Baptist Hospital West, Knoxville, TN; R. Raabe, Providence Medical Research Center, Spokane, WA; D. Pelz, London Health Sciences Centre, London, ON, Canada; G. Stotts, Ottawa Hospital, Ottawa; H. Cloft, Mayo Clinic, Rochester, MN; L. Heller, W. Knopf, St. Joseph’s Hospital of Atlanta, Atlanta; B. Reddy, Piedmont Hospital–Fuqua Heart Center, Atlanta; K. Hodgson, Southern Illinois School of Medicine, Springfield; K. Fraser, Order of St. Francis Saint Francis Medical Center, Peoria, IL; W. Gray, J.P. Mohr, Columbia University Medical Center–New York Presbyterian Hospital, New York; A. Shepard, D. Reddy, Henry Ford Hospital, Detroit; W. Montanera, St. Michael’s Hospital, Toronto; W. Moore, UCLA, Los Angeles; E. Chaikof, B. Stern, Emory University Hospital–Atlanta Veterans Affairs Medical Center, Atlanta; S. Johnson, Cardiovascular Research Foundation–Cardiovascular Associates, Elk Grove, IL; R. Zelman, Cape Cod Research Institute, Hyannis, MA; A. Evans, University of Virginia Health System, Charlottesville; D. Burkart, St. Joseph Medical Center, Kansas City, MO; D. Bandyk, University of South Florida, Tampa; P. Karanjia, Marshfield Clinic, Marshfield, WI; J. Zarghami, Providence Hospital and Medical Centers, Southfield, MI; A. Arthur, J. Barr, Baptist Memorial Hospital, Memphis, TN; M. Mehta, Vascular Interventional Project, Albany, NY; A. Comerota, Jobst Vascular Center, Toledo, OH; K. Natarajan, K. Krol, St. Vincent Hospital, Indianapolis; J. Howington, St. Joseph/Candler Health System, Savannah, GA; D. Selchen, Trillium Health Centre, Mississauga, ON, Canada; M. Schermerhorn, F.W. LoGerfo, Beth Israel Deaconess Medical Center, Boston; S. Laster, St. Luke’s Hospital, Kansas City, MO; M. Sanz, St. Patrick Hospital, Missoula, MT; E. Lopez del Valle, Morton Plant Hospital, Clearwater, FL; J. Andriole, Orlando Regional Healthcare, Orlando, FL; A. Ringer, University of Cincinnati, Cincinnati; J. Martin, Anne Arundel Medical Center, Annapolis, MD; R. Guzman, University of Manitoba, Winnipeg, MB, Canada; P. Teal, Vancouver General Hospital, Vancouver, BC, Canada; F. Hellinger, Florida Hospital, Orlando; G. Petrossian, R.B. Berroya, St. Francis Hospital, Roslyn, NY; M. Bates, Charleston Area Medical Center, Charleston, WV; J. Mills, University of Arizona College of Medicine, Tucson; M. Golden, R. Fairman, Hospital of the University of Pennsylvania, Philadelphia; A. Mansour, Butterworth Hospital, Grand Rapids, MI; A. MacBeth, H. Madyoon, St. Joseph’s Medical Center, Stockton, CA; L.A. Iannone, Iowa Heart Center, Des Moines; K. Hansen, Wake Forest University Health Sciences, Winston-Salem, NC; J. Biller, Loyola University Medical Center, Maywood, IL; J. Shuck, Christiana Care Health Services, Newark, DE; P. Gobin, Weill Cornell Medical College of New York Presbyterian Hospital, New York; K. Dauterman, Rogue Valley Medical Center, Medford, OR; J. Melton, Oklahoma Foundation for Cardiovascular Research, Oklahoma City; D. Benckart, Allegheny General Hospital, Pittsburgh; W. Lesley, Scott and White Memorial Hospital, Temple, TX; M. Belkin, Brigham and Women’s Hospital, Boston; T. Bajwa, St. Luke’s Medical Center, Milwaukee; S. Myla, Hoag Memorial Hospital, Newport Beach, CA; J. Snell, Rush University Medical Center, Chicago; H. Shownkeen, Central DuPage Hospital, Winfield, IL; A. Abou-Chebl, University of Louisville, Louisville, KY; Executive Committee: T.G. Brott (chair), R.W. Hobson, II (deceased), K.W. Beach, D.J. Cohen, J. Cordell, D.E. Cutlip, R.D. Ferguson, L.N. Hopkins, G. Howard, V.J. Howard, L. Keene, B.K. Lal, J.F. Meschia, J.P. Mohr, W.S. Moore, J. Popma, G.S. Roubin, A.J. Sheffet, F.L. Silver; Stroke Adjudication Committee: S.N. Cohen (chair), J. Biller, J.P. Broderick, S. Chaturvedi, M.A. Kalafut, E.J. Skalabrin; Myocardial Infarction Adjudication Committee: J.L. Blackshear (chair), S.P. Glasser, R.J. Prineas; Data and Safety Monitoring Board: J. Marsh (chair), R. Higashida, G. Lamas, B. Tilley, M. Walker, and G.R. Cutter (2001–2002).