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Published online 2010 August 11. doi: 10.1186/1476-4598-9-214

Figure 7

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MiTF mediates signal transduction from Erk1/2 to p21WAF1/CIP1 after UVC and ROS stress. UVC and ROS trigger Erk1/2 activation, which leads to MiTF phosphorylation and degradation, and enables a temporary G1 cell cycle arrest and subsequent cell survival.

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