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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
Clin Transplant. Author manuscript; available in PMC 2011 May 1.
Published in final edited form as:
PMCID: PMC2925539
NIHMSID: NIHMS152157

Prevalence and Determinants of Physical Activity and Fluid Intake in Kidney Transplant Recipients

Elisa J. Gordon, Ph.D., M.P.H., Research Associate Professor, Thomas R. Prohaska, Ph.D., Professor of Public Health, Mary P. Gallant, Ph.D., M.P.H., Associate Professor and Chair, Ashwini R. Sehgal, M.D., Professor of Medicine, David Strogatz, Ph.D., Associate Professor, David Conti, M.D., Department of Surgery, and Laura A. Siminoff, Ph.D., Professor and Chair

Abstract

Background and Significance

Self-care for kidney transplantation is recommended to maintain kidney function. Little is known about levels of self-care practices, and demographic, psychosocial, and health-related correlates.

Aim

We investigated patients’ self-reported exercise and fluid intake, demographic and psychosocial factors associated with these self-care practices, and health-related quality of life.

Methods

Eighty-eight of 158 kidney recipients from two academic medical centers completed a semi-structured interview and surveys 2 months post-transplant.

Results

Most patients were sedentary (76%) with a quarter exercising either regularly (11%) or not at current recommendations (13%). One third (35%) reported drinking the recommended three liters of fluid daily. Multivariate analyses indicated that private insurance, high self-efficacy, and better physical functioning were significantly associated with engaging in physical activity (p<0.05); while male gender, private insurance, high self-efficacy, and not attributing oneself responsible for transplant success were significant predictors of adherence to fluid intake (p<0.05). Despite the significance of these predictors, models for physical activity and fluid intake explained 10–15% of the overall variance in these behaviors. Multivariate analyses indicated that younger age, high value of exercise, and higher social functioning significantly (p<0.05) predicted high self-efficacy for physical activity, while being married significantly (p<0.05) predicted high self-efficacy for fluid intake.

Conclusion

Identifying patients at risk of inadequate self-care practice is essential for educating patients about the importance of self-care.

Keywords: Kidney transplantation, physical activity, exercise, oral rehydration, self-care, self-management, self-efficacy, self-regulation theory, health-related quality of life

INTRODUCTION

Even with advances in preventing and treating acute rejection, late kidney graft loss is a significant problem(1, 2) and post-transplant morbidity and mortality rates remain high.(3) Accordingly, there has been greater emphasis on improving the management of renal transplant recipients to prevent complications after renal transplantation and ensure proper graft functioning and long-term patient survival.(47) Clinical guidelines provide recommendations for managing the long-term care of transplant recipients,(7) including monitoring patients’ health promotion efforts that can mitigate risk factors, such as physical activity and fluid intake, among other self-care behaviors.(8) It is well documented that patient behavior, such as medication adherence, is critical to successful management after kidney transplantation.(9, 10) However, little is known about the prevalence of self-care practices of physical activity and fluid intake among kidney transplant recipients. Moreover, the demographic and psychosocial factors that may be related to physical activity or fluid intake behaviors remain to be determined.

Exercising is of vital importance as a preventive measure for cardiovascular disease; cardiovascular disease is the primary cause of death among kidney recipients.(11, 12) There is some evidence that physical activity is related to graft function. One study of 22 pediatric and adolescent kidney transplant recipients found that impaired maximal oxygen consumption measured using an exercise testing protocol is related to higher creatinine levels.(13) Other studies report that pre-transplant inactivity predicts poor post-transplant graft and patient survival.(14, 15)

In light of the mounting evidence of the positive effect of exercise on graft function, it is imperative that patients routinely engage in physical activity. While kidney recipients engage in more physical activity post-transplant compared to while on dialysis (1619), relatively few meet current recommendations for exercise for adults (20).Most studies of physical activity are cross-sectional and typically assess patients one or more years post-transplant, e.g., (19) thus limiting understanding of activity levels early post-transplant.

Few reports document that increased fluid intake has adverse effects in patients with renal insufficiency.(21, 22) For such patients, clinical recommendations are to decrease fluid intake, since patients with chronic kidney disease do not make normal amounts of urine and a normal fluid intake would lead to congestive heart failure. The case for or against fluid intake in kidney transplant recipients has not been discounted in the literature, and has been minimally empirically tested. Similarly, no study has surveyed transplant clinicians about their recommendations for fluid intake, but variation in practice is likely. Only one study has documented the positive bivariate relationship between fluid adherence and better graft function.(23) Kidney transplant recipients are clinically different from patients with chronic renal insufficiency. In patients with a functioning kidney graft, a normal or higher fluid intake is clinically recommended by some transplant clinicians to keep the kidney well hydrated. In anecdotal findings of adult kidney recipients’ barriers to fluid intake, patients recounted that clinicians attributed dehydration as a cause of their elevated creatinine levels.(24)

This paper examines recent kidney recipients’ physical activity and adherence to fluid intake recommendations because various transplant clinicians recommend these behaviors as essential to the long-term care of the transplant.(6, 7) We also investigate the association between these self-care practices and self-efficacy for these practices, health beliefs, perceived social support, health-related quality of life, and patient demographics. Additionally, we examined the psychosocial determinants of self-efficacy for physical activity and fluid intake.

Examining self-care practices early post-transplant is important because they may be formative in establishing future habits. Examining the social and cultural factors that may affect self-care behaviors is also important for identifying modifiable risk factors. Analyzing self-care at the early post-transplant period (~ 2 months) is reasonable because various transplant clinicians involved in the study encourage patients to walk 1–2 days after surgery, and explain that gradually intensified exercise will foster faster recovery, reduce the risk of complications, and improve well-being. Recovery can take approximately 2 to 12 weeks. Since graft function declines over time, assessing physical activity when post-transplant health is optimal will provide a benchmark for comparison with future time points post-transplant. Transplant clinicians involved in this study also recommend that patients drink 3 liters of fluid daily. Clinicians educate patients about these self-care practices prior to discharge from the hospital, then repeatedly at every postoperative office visit, and then on average every other week for the first three months.

Conceptual Model

Our approach to self-care is guided by the self-regulation model of illness management.(25) This model is based on Social Cognitive Theory which posits that people learn strategies to manage their chronic illness through self-regulation processes of observations, judgments, and reactions.(26) Self-regulation, a critical element to kidney transplant self-care, is the assessment that one can effectively perform a behavior to achieve a desired goal or outcome,(26, 27) and is a predictor of chronic illness self-management.(28, 29) Engagement in self-care requires that patients believe they have the skills, or perceived self-efficacy, to perform self-care practices; belief in one’s ability is a critical element to motivation to perform self-care.(30) Thus, even if patients are highly motivated, they may not engage in self-care if they do not feel capable of doing so. Kidney recipients will continue engaging in recommended physical activity and fluid intake if they observe that their prior self-care practices successfully achieved their expected outcomes.(30) While positive observations reinforce patients’ self-efficacy, those who were less successful in achieving goals will respond to their assessment by adjusting self-care practices accordingly.(27)

Self-efficacy for a specific self-care practice is shaped by interactions between personal, behavioral, and environmental factors.(30) High self-efficacy for physical activity and fluid intake is therefore expected to be guided by internal resourcefulness, health beliefs (attributions), health status, or the presence of social or contextual factors enabling self-care. We had expected that lower levels of health-related quality of life would result in greater difficulty engaging in physical activity.

The self-regulation model posits that cognitive representations influence engagement in health-related behaviors as individuals seek to limit the threat of graft failure, improve health, and cope with illness.(31) Representations may include attributions of the cause of disease, perceived responsibility for care, and the value accorded to treatments for achieving a desired outcome.(32) Three sets of attributions relevant to kidney transplantation include: (1) attributions about the cause of kidney failure, which yields insight into patients’ perceptions about responsibility for the original health problem; (2) attributions of responsibility for ensuring kidney graft survival, which yields insight into patients’ perceptions of responsibility for the successful management of the transplant; and (3) attributions of how much engaging in each self-care practice can prevent loss of kidney function; which yields insight into patients’ perceptions about whether recommended self-care practices make a difference in kidney transplant function. Patients who believe that the cause of kidney failure is their responsibility will be more likely to engage in self-care to improve their health if they also believe that they can perform the behavior and the behavior will help to manage the health concern. Attributions of responsibility for ensuring transplant success can indicate how much patients expect themselves or others to actively manage their own health. Attributions of how engaging in self-care practices can prevent loss of kidney function may provide insight into which self-care activities patients will most likely practice with the expectation that the behavior will enhance graft survival.

METHODS

Patients

All adult kidney transplant recipients were recruited in an incidence cohort from Loyola University Medical Center (LUMC) in Maywood, IL (July 2004 – May 2006) and Albany Medical Center (AMC) in Albany, NY (September 2006 – March 2008). Kidney transplant recipients were eligible for participation if they: were 18 years and older, spoke English, received a kidney transplant within the previous six weeks, and were currently taking immunosuppressants. We approached eligible patients in the transplant clinic waiting room and described the study to obtain initial oral consent and contact information for those interested in participating. For those who provided oral consent, we arranged a date for an interview or called them later that week to set the date.

Interview

Semi-structured interviews were conducted with kidney recipients within 2 months post-transplant either in person or by telephone. The data reported herein are part of a larger, longitudinal study examining self-care, social support, finances, and kidney graft outcomes.(23) This paper reports results from the baseline interview. Topics covered include: a) amount of daily fluid intake and performance of physical activity; b) patients’ perceived ability to engage in fluid intake and physical activity (self-efficacy); c) attributions of causality, responsibility for ensuring graft survival, and perception of how self-care activities may foster graft survival; and d) demographics and medical information. See the Appendix for a copy of the interview schedule. All interviews lasted on average 2 hours. Respondents were compensated $20 for participation. Institutional Review Board approval was obtained from Loyola University Medical Center and Albany Medical Center. Study participants provided written informed consent prior to starting the interview.

Measures

Self-Care Activities

Physical Activity

was assessed through the use of the Physical Activity Scale for the Elderly (PASE).(33) The PASE was designed to assess a continuum of physical activity in epidemiologic studies of people aged 65 years and older, and has been validated in patients on hemodialysis.(34) The PASE is an optimal measure of physical activity for patients with compromised health such as kidney recipients, as they suffer from chronic illnesses common to elderly populations, and even though they may be younger than elderly populations, many are frail. This instrument includes activities at the lower end of the activity spectrum, which are expected in the end-stage renal disease (ESRD) population.(35) The PASE is a self-administered, 21-item instrument that uses 4-point Likert scales to assess the frequency, intensity, and duration of physical activity in three key domains: participation in leisure time activities, i.e., recreational sports and fitness, household activities i.e., vacuuming or lawnwork, and occupational activities i.e., walking or operating machinery over the past 7-days. A sample question is as follows: “Over the past 7 days, how often did you do any exercises specifically to increase muscle strength and endurance, such as weights or pushups, etc.?” PASE scores range from 0 to 795 with higher values representing more physical activity. Internal consistency of all items was α = 0.69, and test-retest reliability coefficient was 0.75.(35, 36) Regular physical activity is defined here as 30 minutes of physical activity three or more times per week. Although PASE is analyzed as a continuous variable, for the purpose of presentation, we categorized PASE scores into ‘sedentary’ (0–99) and ‘active’ (100+). ‘Active’ encompasses both ‘moderate’ (100–150) and ‘regular’ (151+) physical activity levels.

Fluid Intake

Patients were asked how many ounces or liters of fluid they ingested daily. Fluid adherence was determined if patients reported drinking three or more liters of fluid daily, which was the amount recommended at both transplant centers. Fluid intake was analyzed as a dichotomous variable (adherent vs. nonadherent).

Self-Care Perceptions & Beliefs

Self-Efficacy

for engaging in physical activity and for adhering to recommended fluid intake were measured separately, each measured on a 5-point Likert scale (1 = not at all, 5 = a great deal).

Attributions

Three sets of attributions were examined: 1) attributions about the cause of kidney failure, 2) attributions of responsibility for ensuring kidney graft survival, and 3) attributions of how much engaging in each self-care practice can prevent loss of kidney function. A sample question of the third attribution is: “How much do you believe that kidney rejection can be prevented by doing the following activities?” Each attribution set includes four to five questions, each measured on a 5-point Likert scale (1 = not at all, 5 = a great deal). Higher scores reflect greater agreement with the attribution. Individual attribution questions were analyzed either as a dichotomous variable in univariate analysis (1–3 = no agreement with attribution, 4–5 = agreement with attribution), or averaged and analyzed on a 5-point scale in bivariate or multivariate analysis.

Health-Related Quality of Life

was assessed using The Medical Outcomes Study short form 36 (SF-36), which is a general health survey consisting of 36 items scored in eight scales in two key domains of physical and mental health functioning including: physical functioning, role-physical, bodily pain, and general health in the former domain, and vitality, social functioning, role-emotional and mental health in the latter domain.(37) Each scale was tallied and then means were standardized using norm-based scoring described elsewhere,(38) which transforms scores to a mean of 50 and standard deviation of 10 in the general population. Norm-based scoring enables clearer comparison across scales and to the general population. A score of 40 indicates that the health status is below average.(38) Reliability coefficients range from 0.65 to 0.94 across scales.(37) Each of the eight scales was analyzed separately.

Health Status

A measure of overall self-rated health was assessed with a single global item, “How would you rate your health compared to people your age with a transplant?” (‘excellent,’ ‘very good,’ ‘good,’ ‘fair,’ and ‘poor’).

Perceived Social Support

was assessed using the Medical Outcomes Study Social Support Survey (SSS).(39) The SSS was designed for use with chronically ill patients.(40) An example of one item from the SSS is: “Someone to confide in or talk to about yourself or your problems.” The SSS is a self-administered, 20-item instrument that uses a 5-point Likert scale to assess four categories of social support: emotional or informational support; tangible support; positive social interaction; and affection (Overall scale Cronbach α = 0.97; and 0.91 to 0.96 for subscales).(39) Scores range from 0–100; higher scores signify higher levels of support.

Demographics

assessed included gender, age, education, income, primary insurer, race/ethnicity (which was based on self-identification and dichotomized [white versus non-white] due to limited variation in the sample), and travel time to the transplant center.

Clinical information

included cause of ESRD, organ donor source, number of transplants (dichotomized as one or more than one), and time with a transplant as of the date of the interview. This information was obtained from patient self-report and confirmed through medical record review.

Statistical Analysis

The simple analysis of categorical demographic, clinical, and psychosocial predictors of physical activity and self-efficacy (for activity and fluid adherence) was based on comparing the category-specific mean values of PASE scores and levels of self-efficacy. Two-sample t tests were computed for continuous independent variables with dichotomous predictors and one-way analysis of variance was used for predictors with three categories. Spearman correlation coefficients and associated p values were calculated for continuous predictors of physical activity and self-efficacy. For the simple analysis of fluid intake, associations with categorical predictors were tested using Pearson’s Chi-square test, while t tests were used for associations with continuous predictors.

Multivariate regression models were used to examine the statistically independent relationship between patient characteristics and self-care practices as well as self-efficacy. Independent variables included demographic (age, gender, education, race/ethnicity, marital status, travel time to transplant center), socioeconomic (income, education), clinical (cause of ESRD, source of donor kidney, number of transplants), individual attributions, health-related quality of life subscales, social support, and self-efficacy (for models assessing self-care practices). Dependent variables included the two self-care practices (physical activity, fluid intake) and self-efficacy for physical activity and adhering to recommended fluid intake. Linear regression was used for the analysis of physical activity, while logistic regression was used for the analysis of fluid intake and self efficacy (with the latter defined as high for Likert values of 4 or 5). Independent variables were entered into the regression models based on p<0.10 in bivariate analyses and on conceptual justification. Patients with incomplete interviews for key outcome measures were excluded from some analyses resulting in a loss of 2–3 participants. All tests were two-tailed and p < 0.05 was considered statistically significant. All statistical analyses were performed using SPSS 15.0 (SPSS, Inc., Chicago, IL).

RESULTS

Demographics

A total of 90 out of 158 (57%) eligible patients participated. Twenty-two percent (n=35) refused participation due to post-surgical complications, feeling overwhelmed with the transplant, time commitments, burden of paperwork involved, or disinterest; 4% were undecided (n=7); and 16% (n=26) gave oral consent but did not provide written consent or were unable to be reached for an interview. Since two participants had incomplete data, they were excluded from analysis; our final analysis is based on a sample of 88 (42 from LUMC, 46 from AMC). Study participant characteristics are summarized in Table 1. The majority of patients were European American (69%; 17% African American, 8% Hispanic, and 7% other). Ages ranged from 18 to 74, with a mean of 48 years. At the time of the interview, patients had their transplant for an average (mean) 1.6 months (range: 0.5–6.5) (SD: 0.94). There was no significant difference in known demographics between those who participated and refused to participate in the study or between transplant centers. Psychosocial characteristics are presented in Table 3. Patients reported generally high levels of social support. All domains of health-related quality of life were below the general population average, except mental health was slightly above it.

Table 1
Demographic Characteristics of Study Participants in Total and by Self-Care Levels (n=88)
Table 3
Psychosocial Characteristics of Study Participants by Self-Care Levels and Self-Efficacy (n=88)

Self-Care Practice Levels

Table 1 presents the prevalence of physical activity and appropriate fluid intake and the demographic correlates of these self-care practices. As shown, few patients reported reaching optimal self-care levels, with 24% engaging in moderate to regular physical activity, and 35% drinking the recommended three liters of fluid each day. The mean PASE score (75) (SD: 64.6) was lower than that reported in the sedentary elderly general population (131) (SD: 70.4) (age 66.5 +/− 5.3 years).(33) Engaging in more physical activity was associated with having private insurance (p<0.02). Patients who were more likely to adhere to fluid intake requirements were male (p<0.01) and had with private insurance (p<0.04).

Self-Efficacy in Self-Care Practice

Patients’ levels and demographic correlates of self-efficacy for physical activity and fluid intake are presented in Table 2. On average, most patients (83%) reported having high self-efficacy for fluid intake, but only half (49%) had high self-efficacy for exercise. High self-efficacy for exercise was associated with better self-rated health (p<0.001). High self-efficacy for fluid intake was associated with male gender (p=0.004), being married (p<0.02), mid-higher incomes (p<0.05), and better self-rated health (p<0.01).

Table 2
Patient Characteristics Associated with Self-Efficacy for Self-Care Practicesa,b

Table 3 presents the associations between participants’ psychosocial characteristics and self-care and self-efficacy levels. As expected, self-efficacy for exercise was positively correlated with engaging in physical activity (p<0.001). Similarly, self-efficacy for fluid intake was positively correlated with adhering to fluid intake requirements (p<.001). Psychosocial characteristics, including health-related quality of life domains of physical functioning, role physical, social functioning, vitality, and general health were associated with greater engagement in physical activity and/or self-efficacy for physical activity. . Patients who engaged in more physical activity and had higher self-efficacy for exercise reported better health-related quality of life in several SF36 subscales. Patients who had greater tangible support and total social support reported having higher self-efficacy for fluid intake.

Attributions Relating to Self-Care Management

Table 4 presents findings pertaining to the association between attributions and self-care practices. This includes the level of attribution for cause of kidney failure, responsibility for managing their transplant, and the level of belief that the self-care practice can prevent kidney rejection. Virtually all patients attributed responsibility for ensuring graft survival to themselves (99%), followed closely by their doctor (78%), God (51%), and their family (40%). This means that patients felt responsible for managing their transplant, but they also believed that their physician played a role in transplant management. However, the fact that half of the patients believed that God was very or entirely responsible for managing their transplant suggests that patients may play a passive role in transplant management.

Table 4
Relationship Between Attributions about Transplantation and Self-Care Practicesa

An examination of the relationship between attributions and self-care behaviors revealed that patients who engaged in more physical activity attributed less responsibility to their family (p<0.05). The negative correlation suggests that lower belief in the attribution leads to higher physical activity. Patients who were more adherent with fluid intake attributed less responsibility to themselves for transplant success (t=−1.99; p<0.06) (findings not presented).

Patients attributed the greatest value to drinking fluids for preventing loss of kidney function (85%), followed by exercising (68%), and maintaining one’s diet (66%). Patients with higher self-efficacy for physical activity were more likely to attribute importance to exercise for ensuring graft survival (r=0.42; p<0.001) (findings not presented).

Multivariate Analysis for Self-Care Practices

Multivariate analysis was performed for predictors of physical activity and for adherence to fluid recommendations, as presented in Table 5. The overall predictive ability of our models was in the 10–15% R-squared range. Significant predictors of physical activity included: having private insurance, high self-efficacy for exercise, and better health-related quality of life, physical functioning (p<0.05). The PASE score of patients with private insurance was 29 points higher than the score of patients with public insurance. An increase of one on the Likert scale for exercise self-efficacy was associated with an increase in PASE by 13 points. An increase by 1 standard deviation in SF36 was associated with an increase in PASE by 20 points. Predictors of adherence to fluid intake recommendations included: male gender, private insurance, high self-efficacy for fluid intake, and attributing one-self as not responsible for the transplant’s success (p<0.05). For example, the logistic coefficients for the prediction of fluid intake indicate that the odds of adherence were 5.8 times greater for men than women, and 7.6 times greater with every unit increase in self-efficacy for meeting the recommendation for fluid intake.

 Table 5
Multivariate Analyses of Self-Care Practices

Multivariate Analysis for Self-Efficacy for Self-Care Practices

Multivariate analysis was separately performed for predictors of self-efficacy for physical activity and fluid intake as shown in Table 6. Self-efficacy for physical activity was significantly greater (p<0.05) among younger patients, those who accorded high value to physical activity for ensuring graft survival, and patients with better social functioning. The logistic coefficients and specified differences in the predictors can be used to quantify these associations. For example, with every additional 10 years of age there is a 50% reduction in the odds of self-efficacy for physical activity; an increase of one on the Likert scale for the attribution that exercise prevents rejection was associated with a nearly threefold increase in the odds of high self-efficacy for exercise; while an increase by one standard deviation (10 points) in the SF-36 social function score was associated with almost a two-fold increase in the odds of high self-efficacy for exercise. In the logistic regression model for self-efficacy in fluid intake, the only statistically significant (p< 0.05) predictor of high self-efficacy was being married.

Table 6
Multivariate Analyses of Self-Efficacy for Self-Care Practices

DISCUSSION

This study identified several key behavioral and psychosocial predictors of self-care behaviors associated with post-transplant success. Specifically, we found that most patients are not appropriately engaging in recommended physical activity and fluid intake. Other research corroborates our findings.(16, 17, 19) The low rates of adherence are of serious concern because greater physical activity is positively related to improved kidney graft function over time.(23) Additionally, greater physical activity is related to improved cardiorespiratory fitness, muscle strength, physical functioning,(17) and quality of life,(20) a reduction in cardiovascular risk factors,(12, 41) and in adverse effects associated with immunosuppressive therapy including weight gain,(42) and reductions in osteoporosis and sarcopenia.(43, 44) Because of the wide-spread beneficial effects of physical activity for ESRD, it is imperative to increase kidney transplant recipients’ exercise levels.

We found that patients with private insurance as their primary insurer were more likely to engage in physical activity. Other studies have similarly found that lower SES is related to less physical activity in diabetics and the general population.(45) Sanchez and colleagues found that barriers to self-reported exercise were more likely to be experienced by older patients and those with worse physical or health conditions.(19)

Our study corroborates and advances the literature on psychosocial correlates of physical activity among kidney transplant recipients. We found that self-efficacy for physical activity is associated with physical activity levels, consistent with self-regulation theory. This finding is compatible with reviews of the literature that found that self-efficacy for exercise was consistently associated with physical activity.(46) Sanchez and colleagues likewise found that patients believing in their ability to be physically active were significantly more likely to be active. (19) Self-efficacy has been shown to be the single most important predictor of engaging in physical activity.(46) This suggests that strategies to promote self-efficacy for exercise among kidney recipients may ultimately increase the likelihood that they will engage in physical activity. Greater emphasis must therefore be placed on improving kidney recipients’ self-efficacy for physical activity in the post-transplant period. Self-efficacy for exercise was related to the attribution that exercise contributes to graft function, as well as to patients’ better overall health and better social functioning. Sanchez and colleagues found that 11% reported lack of knowledge of the benefits of physical activity was a barrier, but was not significantly related, to activity levels.(19) Similar to Sanchez and colleagues,(19) we found that this attribution was not directly related to kidney recipients’ engagement in physical activity. This suggests that efforts to modify patients’ attributions may result in greater self-efficacy for engaging in physical activity.

Contrary to expectations, adherence to fluid recommendations was negatively related to higher responsibility for oneself for fluid intake. Qualitative interviews corroborate this point, as kidney recipients reported relying on family members to remind them to drink or bring them fluids.(24) It may be that some patients lack the ability to monitor fluid intake and thirst, and require others to remind them. Additional research cuing in on the ability to effectively monitor fluid intake should be explored as a possible explanation for a sense of responsibility for fluid intake.

We found that most patients believed that physical activity and fluid intake were only moderately important for maintaining proper kidney function. This indicates that many patients do not recognize the value that self-care activities confer to health. Without such knowledge, patients are less likely to engage in self-care practices. Other research has similarly shown that attributions are associated with health outcomes including self-care practice, less care seeking, functional decrements in chronic disease, and mortality.(47, 48) Systematic post-transplant education and documentation about the value of self-care over time is essential. While current Centers for Medicare and Medicaid Services regulations mandate that all transplant centers provide recipients nutritional assessments,(49) it is not clear whether these other self-care practices have been incorporated into routine post-transplant education.

Recommendations

More effective patient management is needed to improve patients’ physical activity and fluid intake. Clinical recommendations for managing kidney recipients should include guidance regarding patients at risk of inactivity and dehydration. Specifically, more effective communication is needed among females and patients with Medicare or Medicaid as the primary insurer, with regard to fluid intake. Our findings of low self-efficacy for physical activity (49%) and for fluid intake (17%), suggests that educational strategies should also focus on motivational strategies to build confidence in self-care practices, thereby suggesting the need for new communication approachesThis is particularly relevant given that recent legislation supports educational services to patients with kidney disease as a quality improvement measure.(50) In light of the benefits of regular exercise for ESRD patients noted above, repeated health education messages involving clinicians as well as health educators is well justified. Monitoring and documenting such efforts in clinical settings may facilitate this process (51). Incorporating structured educational messages during the post-transplant period is warranted and has been documented by recent studies.(52, 53)

Future Research

Research found that kidney recipients are confused about clinicians’ recommendations for physical activity and fluid intake, which limited their engagement in these practices.(24) Accordingly, research should examine how transplant clinicians educate patients about self-care activities, and whether clinicians appropriately emphasize the importance of self-care activities for graft survival. The findings suggest that the educational component should include strategies to improve patients’ self-efficacy levels for physical activity and fluid intake. While there are several strategies for improving self-efficacy for physical activity, recommendations for best practices in physical activity education and counseling recommend strategies such as: health contracts, tailoring exercise programs to the needs and interest of individuals, and encouraging social support for exercise.(46, 54) Kidney transplant recipients may also benefit from attribution retraining about the value of physical activity and responsibility for managing the transplant. Attribution retraining has been used successfully to change older adults’ attributions about exercise, which improved their health outcomes.(55)

Limitations

The recruitment attrition rate of 43% may have resulted in a biased sample. Recruitment attrition may be related to poor health which may be correlated with poorer engagement in self-care behaviors. That 22% of patients refused participation due to slow recovery and feeling overwhelmed by the transplant among other reasons, supports this point. Generalizability of our findings should be cautioned. The relatively highly educated sample may be a vestige of characteristics of patients willing to participate in the study. Second, the small sample size limited our ability to undertake multivariable analyses and the R-squared values of 10–15% were relatively modest. The statistical power to detect predictors of behavior and self-efficacy is limited by the size of our study population, so some moderate associations of interest may not be revealed in these analyses. The multi-site study design provides support for the external validity; no significant differences in self-care practices were found between sites. Since we assessed self-care practices early post-transplant, patients are likely to be more adherent to clinicians’ physical activity and fluid intake recommendations given their high excitement level. Research demonstrating declines in medication adherence over time supports this point.(56) Although patients may not have adequately recovered from surgery or fully integrated self-care practices into daily routines, patients in the present study reported establishing self-care routines early post-transplant.(24, 57) While the assessment of self-care was based on self-report, patients’ estimates of fluid intake are likely relatively accurate given they are required to track the milliliters of fluid they drink and void for the first two weeks post-transplant.

CONCLUSION

Kidney transplant recipients are not practicing optimal physical activity or fluid intake in the early post-transplant period. Improved post-transplant patient management is needed to enhance patients’ self-care care practices. Since self-efficacy and health attributions were predictors of self-care practice, transplant clinicians should focus educational efforts on addressing patients’ health beliefs and removing barriers to self-care.

Supplementary Material

Appendix

ACKNOWLEDGEMENTS

Thanks go to David Holt, MD, for opening his clinic to this research. We are grateful for the research assistance of Mark Wodziak, Laura Grillo, Randy Hohle, Melisa Kiyamu, and Ashar Ata, and to Jack Kress for his helpful comments on an earlier draft.

Support and Financial Disclosure Declaration

Dr. Gordon is supported by a Career Development Award from the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD (DK063953).

Footnotes

There is no conflict of interest by the authors

Contributor Information

Elisa J. Gordon, Institute for Healthcare Studies, Feinberg School of Medicine, Department of Surgery, Transplant Surgery Division, Northwestern University, 750 N. Lakeshore Drive, 10th floor, Chicago, IL 60611.

Thomas R. Prohaska, Co-Director, Center for Research on Health and Aging, Institute for Health Research and Policy (MC 275), School of Public Health, University of Illinois at Chicago, 1747 West Roosevelt Road, Room 558, Chicago, IL 60608.

Mary P. Gallant, Department of Health Policy, Management, & Behavior, School of Public Health, University at Albany, SUNY, One University Place, Rensselaer, NY 12144-3456.

Ashwini R. Sehgal, Center for Reducing Health Disparities and Division of Nephrology, MetroHealth Medical Center, Case Western Reserve University, Rammelkamp Research & Educ. Bldg., R221, 2500 MetroHealth Drive, Cleveland, OH 44109-1998.

David Strogatz, Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, SUNY, One University Place, Rensselaer, NY 12144-3456.

David Conti, Division of Transplantation, Albany Medical Center, 47 New Scotland Avenue, Albany, NY 12208.

Laura A. Siminoff, Department of Social and Behavioral Health, School of Medicine, Virginia Commonwealth University, PO Box 980149, 1112 E Clay St., Richmond, VA 23298, 1112 E Clay St., Richmond, VA 23298.

REFERENCES

1. Kaneku HK, Terasaki PI. Thirty year trend in kidney transplants: UCLA and UNOS Renal Transplant Registry. Clin Transpl. 2006:1. [PubMed]
2. Magee C, Pascual M. Update in renal transplantation. Arch Intern Med. 2004;164(13):1373. [PubMed]
3. USRDS. National Institutes of Health NIoDaDaKD. Bethesda, MD: 2007. USRDS 2007 Annual Data Report: Atlas of Chronic Kidney Disease and end-stage renal disease in the United States. ed.
4. Djamali A, Samaniego M, Muth B, et al. Medical care of kidney transplant recipients after the first posttransplant year. Clin J Am Soc Nephrol. 2006;1(4):623. [PubMed]
5. EBPG EGoRT. European best practice guidelines for renal transplantation. Section IV: Long-term management of the transplant recipient. Nephrol Dial Transplant. 2002;17 Suppl 4:1. [PubMed]
6. Cohen D, Galbraith C. General health management and long-term care of the renal transplant recipient. Am J Kidney Dis. 2001;38(6) Suppl 6:S10. [PubMed]
7. Kasiske BL, Vazquez MA, Harmon WE, et al. Recommendations for the outpatient surveillance of renal transplant recipients. American Society of Transplantation. J Am Soc Nephrol. 2000;11 Suppl 15:S1. [PubMed]
8. Program TTPP. Realistic Expectations: A Guide for post-transplant kidney patients. Nutley: Roche Laboratories Inc; 1999.
9. Takemoto SK, Pinsky BW, Schnitzler MA, et al. A retrospective analysis of immunosuppression compliance, dose reduction and discontinuation in kidney transplant recipients. Am J Transplant. 2007;7(12):2704. [PubMed]
10. Butler JA, Roderick P, Mullee M, Mason JC, Peveler RC. Frequency and impact of nonadherence to immunosuppressants after renal transplantation: a systematic review. Transplantation. 2004;77(5):769. [PubMed]
11. Shirali AC, Bia MJ. Management of cardiovascular disease in renal transplant recipients. Clin J Am Soc Nephrol. 2008;3(2):491. [PubMed]
12. Painter PL, Hector L, Ray K, et al. Effects of exercise training on coronary heart disease risk factors in renal transplant recipients. Am J Kidney Dis. 2003;42(2):362. [PubMed]
13. Weaver DJ, Jr, Kimball TR, Knilans T, et al. Decreased maximal aerobic capacity in pediatric chronic kidney disease. J Am Soc Nephrol. 2008;19(3):624. [PubMed]
14. Yango AF, Gohh RY, Monaco AP, et al. Excess risk of renal allograft loss and early mortality among elderly recipients is associated with poor exercise capacity. Clin Nephrol. 2006;65(6):401. [PubMed]
15. Kutner NG, Zhang R, Bowles T, Painter P. Pre-transplant physical functioning and kidney patients' risk for posttransplantation hospitalization/death: evidence from a national cohort. Clin J Am Soc Nephrol. 2006;1(4):837. [PubMed]
16. Nielens H, Lejeune TM, Lalaoui A, Squifflet JP, Pirson Y, Goffin E. Increase of physical activity level after successful renal transplantation: a 5 year follow-up study. Nephrol Dial Transplant. 2001;16(1):134. [PubMed]
17. VandenHam E. Relation between steroid dose, body composition and physical activity in renal transplant patients. Transplantation. 2000;69:1591. [PubMed]
18. Nelson ME, Rejeski WJ, Blair SN, et al. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Circulation. 2007;116(9):1094. [PubMed]
19. Sanchez ZV, Cashion AK, Cowan PA, Jacob SR, Wicks MN, Velasquez-Mieyer P. Perceived barriers and facilitators to physical activity in kidney transplant recipients. Progress in Transplantation. 2007;17:324. [PubMed]
20. Painter PL, Topp KS, Krasnoff JB, et al. Health-related fitness and quality of life following steroid withdrawal in renal transplant recipients. Kidney Int. 2003;63(6):2309. [PubMed]
21. Hebert LA, Greene T, Levey A, Falkenhain ME, Klahr S. High urine volume and low urine osmolality are risk factors for faster progression of renal disease. Am J Kidney Dis. 2003;41(5):962. [PubMed]
22. Wenzel U. My Doctor Said I Should Drink a Lot! Recommendations for Fluid Intake in Patients with Chronic Kidney Disease. Clin J Am Soc Nephrol. 2006;1:344. [PubMed]
23. Gordon EJ, Prohaska TR, Gallant M, Sehgal AR, Strogatz D, Yucel R, Conti D, Siminoff LA. Longitudinal analysis of physical activity, fluid intake, and graft function among kidney transplant recipients. Transplant International. 2009 in press. [PMC free article] [PubMed]
24. Gordon EJ, Prohaska TR, Gallant M, Siminoff LA. Self-Care Strategies and Barriers Among Kidney Transplant Recipients: A Qualitative Study. Chronic Illness. 2009;5(2):75. [PMC free article] [PubMed]
25. Leventhal. Self-regulation, health, and behavior: A perceptual-cognitive approach. Psychol Health. 1988;13:717.
26. Bandura A. Self Efficacy: The exercise of control. New York: Freeman; 1997.
27. Clark NM, Gong M, Kaciroti N. A model of self-regulation for control of chronic disease. Health Educ Behav. 2001;28(6):769. [PubMed]
28. Johnston-Brooks CH, Lewis MA, Garg S. Self-efficacy impacts self-care and HbA1c in young adults with Type I diabetes. Psychosom Med. 2002;64(1):43. [PubMed]
29. Sarkar U, Fisher L, Schillinger D. Is self-efficacy associated with diabetes self-management across race/ethnicity and health literacy? Diabetes Care. 2006;29(4):823. [PubMed]
30. Prohaska TR, Lorig K. What do we know about what works? The role of theory in patient education. In: Lorig K, editor. Patient Education: A Practical Approach. Thousand Oaks, CA: Sage Publications; 2001. p. 21.
31. Wearden AJ, Hynd K, Smith H, Davies R, Tarrier N. Idiosyncratic personal explanations for blood glucose events are associated with poorer self-management and glycemic control in adult patients with long-standing type 1 diabetes. Diabetes Care. 2006;29(6):1208. [PubMed]
32. Weiner B. An attributional theory of achievement motivation and emotion. Psychol Rev. 1985;92(4):548. [PubMed]
33. Washburn RA, McAuley E, Katula J, Mihalko SL, Boileau RA. The physical activity scale for the elderly (PASE): evidence for validity. J Clin Epidemiol. 1999;52(7):643. [PubMed]
34. Johansen KL, Painter P, Kent-Braun JA, et al. Validation of questionnaires to estimate physical activity and functioning in end-stage renal disease. Kidney Int. 2001;59(3):1121. [PubMed]
35. Harada ND, Chiu V, King AC, Stewart AL. An evaluation of three self-report physical activity instruments for older adults. Med Sci Sports Exerc. 2001;33(6):962. [PubMed]
36. Washburn RA, Smith KW, Jette AM, Janney CA. The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol. 1993;46(2):153. [PubMed]
37. McHorney C, Ware J, Jr, Lu JF, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Med Care. 1994;32(1):40. [PubMed]
38. Ware J. The SF Community - SF-36® Health Survey Update. 2009.
39. Sherbourne CD, Stewart AL. The MOS social support survey. Soc Sci Med. 1991;32(6):705. [PubMed]
40. McQuellon RP, Russell GB, Rambo TD, et al. Quality of life and psychological distress of bone marrow transplant recipients: the 'time trajectory' to recovery over the first year. Bone Marrow Transplant. 1998;21(5):477. [PubMed]
41. Painter P. Exercise after renal transplantation. Adv Ren Replace Ther. 1999;6(2):159. [PubMed]
42. Friedman AN, Miskulin DC, Rosenberg IH, Levey AS. Demographics and trends in overweight and obesity in patients at time of kidney transplantation. Am J Kidney Dis. 2003;41(2):480. [PubMed]
43. Cordier P, Decruynaere C, Devogelaer JP. Bone mineral density in posttransplantation patients: effects of physical activity. Transplant Proc. 2000;32(2):411. [PubMed]
44. Grotz WH, Mundinger FA, Rasenack J, et al. Bone loss after kidney transplantation: a longitudinal study in 115 graft recipients. Nephrol Dial Transplant. 1995;10(11):2096. [PubMed]
45. Barrett JE, Plotnikoff RC, Courneya KS, Raine KD. Physical activity and type 2 diabetes: exploring the role of gender and income. Diabetes Educ. 2007;33(1):128. [PubMed]
46. Conn VS, Valentine JC, Cooper HM. Interventions to increase physical activity among aging adults: a meta-analysis. Ann Behav Med. 2002;24(3):190. [PubMed]
47. Eakin E. The patients' perspective on the self-management of chronic obstructive pulmonary disease. J Health Psychol. 1997;2(245) [PubMed]
48. Williamson JD, Fried LP. Characterization of older adults who attribute functional decrements to "old age". J Am Geriatr Soc. 1996;44(12):1429. [PubMed]
49. Department HaHS. Services DoHaH. ed 2008. Hospital Conditions of Participation: Requirements for Approval and Re-Approval of Transplant Centers To Perform Organ Transplants; Final Rule. [PubMed]
50. H.R. Medicare Improvements for Patients and Providers Act of 2008. 2008
51. Schäfer-Keller P, Dickenmann M, Berry DL, Steiger J, Bock A, De Geest S. Computerized patient education in kidney transplantation: Testing the content validity and usability of the Organ Transplant Information System (OTIS) Patient Educ Couns. 2009;74(1):110. [PubMed]
52. Mason J, Khunti K, Stone M, Farooqi A, Carr S. Educational interventions in kidney disease care: a systematic review of randomized trials. Am J Kidney Dis. 2008;51(6):933. [PubMed]
53. Boegner C, Fontbonne A, Gras Vidal MF, Mouls P, Monnier L. Evaluation of a structured educational programme for type 2 diabetes patients seen in private practice. Diabetes Metab. 2008;34(3):243. [PubMed]
54. Cress ME, Buchner DM, Prohaska T, et al. Best practices for physical activity programs and behavior counseling in older adult populations. J Aging Phys Act. 2005;13(1):61. [PubMed]
55. Sarkisian CA, Prohaska TR, Davis C, Weiner B. Pilot test of an attribution retraining intervention to raise walking levels in sedentary older adults. J Am Geriatr Soc. 2007;55(11):1842. [PubMed]
56. Chisholm MA, Vollenweider LJ, Mulloy LL, et al. Renal transplant patient compliance with free immunosuppressive medications. Transplantation. 2000;70(8):1240. [PubMed]
57. Gordon EJ, Gallant MP, Sehgal AR, Conti D, Siminoff LA. Medication-taking among adult renal transplant recipients: Barriers and strategies. Transplant International. 2009;22(5):534. [PMC free article] [PubMed]