Search tips
Search criteria 


Logo of jcinvestThe Journal of Clinical Investigation
J Clin Invest. 1972 November; 51(11): 2977–2980.
PMCID: PMC292449

HL-A8: a genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy


Histocompatibility antigen HL-A8 was found in 58% of 26 patients with dermatitis herpetiformis (DH) compared to 24% of a normal group. This difference in antigen frequency is significant at the P < 0.003 level. In a previous study, the frequency of this same genetic marker was found to be significantly increased in patients with gluten-sensitive enteropathy (GSE) (88% in patients vs. 22% in controls). The finding of an increased incidence of the HL-A8 antigen in both DH and GSE supports the concept that these diseases are related and provides a genetic basis for the association between the two.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (578K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Shuster S, Watson AJ, Marks J. Coeliac syndrome in dermatitis herpetiformis. Lancet. 1968 May 25;1(7552):1101–1106. [PubMed]
  • Brow JR, Parker F, Weinstein WM, Rubin CE. The small intestinal mucosa in dermatitis herpetiformis. I. Severity and distribution of the small intestinal lesion and associated malabsorption. Gastroenterology. 1971 Mar;60(3):355–361. [PubMed]
  • Falchuk ZM, Rogentine GN, Strober W. Predominance of histocompatibility antigen HL-A8 in patients with gluten-sensitive enteropathy. J Clin Invest. 1972 Jun;51(6):1602–1605. [PMC free article] [PubMed]
  • Katz SI, Halprin KM, Inderbitzin TM. The use of human skin for the detection of anti-epithelial autoantibodies. A diagnostic and prognostic test. J Invest Dermatol. 1969 Dec;53(6):390–399. [PubMed]
  • Mittal KK, Mickey MR, Singal DP, Terasaki PI. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation. 1968 Nov;6(8):913–927. [PubMed]
  • Albert ED, Mickey MR, Terasaki PI. Genetics of four new HL-A specificities in the Caucasian and Negro populations. Transplant Proc. 1971 Mar;3(1):95–100. [PubMed]
  • Marks R. Dermatitis herpetiformis and the gastro-intestinal tract. Trans St Johns Hosp Dermatol Soc. 1968;54(2):141–147. [PubMed]
  • Fry L, Keir P, McMinn RM, Cowan JD, Hoffbrand AV. Small-intestinal structure and function and haematological changes in dermatitis herpetiformis. Lancet. 1967 Oct 7;2(7519):729–733. [PubMed]
  • Weinstein WM, Brow JR, Parker F, Rubin CE. The small intestinal mucosa in dermatitis herpetiformis. II. Relationship of the small intestinal lesion to gluten. Gastroenterology. 1971 Mar;60(3):362–369. [PubMed]
  • McDevitt HO, Benacerraf B. Genetic control of specific immune responses. Adv Immunol. 1969;11:31–74. [PubMed]
  • Loeb PM, Strober W, Falchuk ZM, Laster L. Incorporation of L-leucine-14C into immunoglobulins by jejunal biopsies of patients with celiac sprue and other gastrointestinal diseases. J Clin Invest. 1971 Mar;50(3):559–569. [PMC free article] [PubMed]
  • van der Meer JB. Granular deposits of immunoglobulins in the skin of patients with dermatitis herpetiformis. An immunofluorescent study. Br J Dermatol. 1969 Jul;81(7):493–503. [PubMed]
  • Chorzelski TP, Beutner EH, Jablonska S, Blaszczyk M, Triftshauser C. Immunofluorescence studies in the diagnosis of dermatitis herpetiformis and its differentiation from bullous pemphigoid. J Invest Dermatol. 1971 May;56(5):373–380. [PubMed]

Articles from The Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation