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Logo of jcinvestThe Journal of Clinical Investigation
 
J Clin Invest. 1972 November; 51(11): 2977–2980.
PMCID: PMC292449

HL-A8: a genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy

Abstract

Histocompatibility antigen HL-A8 was found in 58% of 26 patients with dermatitis herpetiformis (DH) compared to 24% of a normal group. This difference in antigen frequency is significant at the P < 0.003 level. In a previous study, the frequency of this same genetic marker was found to be significantly increased in patients with gluten-sensitive enteropathy (GSE) (88% in patients vs. 22% in controls). The finding of an increased incidence of the HL-A8 antigen in both DH and GSE supports the concept that these diseases are related and provides a genetic basis for the association between the two.

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Selected References

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  • Shuster S, Watson AJ, Marks J. Coeliac syndrome in dermatitis herpetiformis. Lancet. 1968 May 25;1(7552):1101–1106. [PubMed]
  • Brow JR, Parker F, Weinstein WM, Rubin CE. The small intestinal mucosa in dermatitis herpetiformis. I. Severity and distribution of the small intestinal lesion and associated malabsorption. Gastroenterology. 1971 Mar;60(3):355–361. [PubMed]
  • Falchuk ZM, Rogentine GN, Strober W. Predominance of histocompatibility antigen HL-A8 in patients with gluten-sensitive enteropathy. J Clin Invest. 1972 Jun;51(6):1602–1605. [PMC free article] [PubMed]
  • Katz SI, Halprin KM, Inderbitzin TM. The use of human skin for the detection of anti-epithelial autoantibodies. A diagnostic and prognostic test. J Invest Dermatol. 1969 Dec;53(6):390–399. [PubMed]
  • Mittal KK, Mickey MR, Singal DP, Terasaki PI. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation. 1968 Nov;6(8):913–927. [PubMed]
  • Albert ED, Mickey MR, Terasaki PI. Genetics of four new HL-A specificities in the Caucasian and Negro populations. Transplant Proc. 1971 Mar;3(1):95–100. [PubMed]
  • Marks R. Dermatitis herpetiformis and the gastro-intestinal tract. Trans St Johns Hosp Dermatol Soc. 1968;54(2):141–147. [PubMed]
  • Fry L, Keir P, McMinn RM, Cowan JD, Hoffbrand AV. Small-intestinal structure and function and haematological changes in dermatitis herpetiformis. Lancet. 1967 Oct 7;2(7519):729–733. [PubMed]
  • Weinstein WM, Brow JR, Parker F, Rubin CE. The small intestinal mucosa in dermatitis herpetiformis. II. Relationship of the small intestinal lesion to gluten. Gastroenterology. 1971 Mar;60(3):362–369. [PubMed]
  • McDevitt HO, Benacerraf B. Genetic control of specific immune responses. Adv Immunol. 1969;11:31–74. [PubMed]
  • Loeb PM, Strober W, Falchuk ZM, Laster L. Incorporation of L-leucine-14C into immunoglobulins by jejunal biopsies of patients with celiac sprue and other gastrointestinal diseases. J Clin Invest. 1971 Mar;50(3):559–569. [PMC free article] [PubMed]
  • van der Meer JB. Granular deposits of immunoglobulins in the skin of patients with dermatitis herpetiformis. An immunofluorescent study. Br J Dermatol. 1969 Jul;81(7):493–503. [PubMed]
  • Chorzelski TP, Beutner EH, Jablonska S, Blaszczyk M, Triftshauser C. Immunofluorescence studies in the diagnosis of dermatitis herpetiformis and its differentiation from bullous pemphigoid. J Invest Dermatol. 1971 May;56(5):373–380. [PubMed]
  • RUBIN W, FAUCI AS, MARVIN SF, SLEISENGER MH, JEFRIES GH. IMMUNOFLUORESCENT STUDIES IN ADULT CELIAC DISEASE. J Clin Invest. 1965 Mar;44:475–485. [PMC free article] [PubMed]

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