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To the editor:
Dr. Brind claims that by restricting our analyses  to invasive breast cancer and censoring the in situ cases at the time of their diagnosis, we made a methodologic error. In fact, we did not. Women were at risk of invasive breast cancer up to the dates of their in situ diagnoses. Nevertheless, we repeated our analyses using Dr. Brind’s proposed method, excluding all women who were diagnosed with in situ breast cancer during follow up. In total, we excluded 708 (159 nulliparous and 549 parous) women with in situ breast cancer from the analysis. This had absolutely no impact on our results (see Table). We continue to find no statistically or clinically significant association between induced abortion and breast cancer. Disagreements about the quality of studies occur in science and we continue to disagree with Dr. Brind regarding studies involving databases of fetal death certificates which are known to be incomplete. The analytic concern posed by Dr. Brind did not constitute a bias in our study. Using standard research methods in this well studied prospective cohort of women, we saw no evidence of a relationship between incomplete pregnancy and subsequent development of breast cancer.
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Katherine DeLellis Henderson, City of Hope National Medical Center, Division of Population Sciences, Department of Cancer Etiology, 1500 East Duarte Rd., Duarte, CA 91010, Tel: 626-HOPE (4673) EX 61435, 626 471-7308, e-mail: gro.hoc@nosrednehk.
Leslie Bernstein, City of Hope National Medical Center, Division of Population Sciences, Department of Cancer Etiology, 1500 East Duarte Rd., Duarte, CA 91010.