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Ann Pediatr Cardiol. 2010 Jan-Jun; 3(1): 93.
PMCID: PMC2921530

Cardiac Candida krusei infection

Sir,

I read the report by Patted et al. on cardiac Candida krusei infection presenting as a right ventricular mass with great interest.[1] Patted et al. have mentioned that necrotizing enterocolitis and disseminated fungal infection result in an adverse outcome as was seen in their case.[1] Indeed, Candida krusei infection is difficult to treat. Majority of the reported cases with hematogenous spread have died[2] Basic antifungal treatment such as Amphotericin B administration is usually unsuccessful.[3] In the case of cardiac infection, cardiac ischemia leading to death has also been reported.[2] Intravenous Caspofungin therapy has been reported to be the only successful treatment for this condition.[4]

REFERENCES

1. Patted SV, Halkati PC, Yavagal ST, Patil R. Candida krusei infection presenting as a right ventricular mass in a two month old Infant. Ann Pediatr Card. 2009;2:170–2. [PMC free article] [PubMed]
2. Safdar A, Bannister TW, Safdar Z. The predictors of outcome in immunocompetent patients with hematogenous candidiasis. Int J Infect Dis. 2004;8:180–6. [PubMed]
3. Petrocheilou-Paschou V, Georgilis K, Kontoyannis D, Nanas J, Prifti H, Costopoulos H, et al. Pneumonia due to Candida krusei. Clin Microbiol Infect. 2002;8:806–9. [PubMed]
4. Rajendram R, Alp NJ, Mitchell AR, Bowler IC, Forfar JC. Candida prosthetic valve endocarditis cured by caspofungin therapy without valve replacement. Clin Infect Dis. 2005;40:e72–4. [PubMed]

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