Search tips
Search criteria 


Logo of envhperEnvironmental Health PerspectivesBrowse ArticlesAbout EHPGeneral InformationAuthorsMediaProgramsPartnerships
Environ Health Perspect. 2010 August; 118(8): A332.
PMCID: PMC2920099

Dietary Arsenic Exposure: Xue et al. Respond

Jianping Xue, Valerie Zartarian, and Shi V. Liu
U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory Research Triangle Park, North Carolina, E-mail: vog.ape@gnipnaij.eux
Sheng-Wei Wang
Graduate Institute of Environmental Health, National Taiwan University, Taipei, Taiwan

In our article (Xue et al. 2010), we cited Petito Boyce et al. (2008) based on their major conclusion stated at the end of their abstract that, “typical and high-end background exposures to inorganic arsenic in U.S. populations do not present elevated risks of carcinogenicity.” We agree with Petito Boyce et al. that we “missed an opportunity to provide additional support for” our overall conclusions, and very much appreciate that they have offered this detailed comparison showing the agreement between our modeling results.

Our discussion of Petito Boyce et al. (2008)’s conclusions was intended to bolster the need to develop a more comprehensive analysis of the sources of inorganic arsenic exposure, not to suggest that their exposure analysis was incomplete or inaccurate.


  • Petito Boyce CP, Lewis AS, Sax SN, Eldan M, Cohen SM, Becj BD. Probabilistic analysis of human health risks associated with background concentrations of inorganic arsenic: use of a margin of exposure approach. Hum Ecol Risk Assess. 2008;14:1159–1201.
  • Xue J, Zartarian V, Wang SW, Liu, SV, Georgopoulos P. Probabilistic modeling of dietary arsenic exposure and dose and evaluation with 2003–2004 NHANES data. Environ Health Perspect. 2010;118:345–350. [PMC free article] [PubMed]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Science