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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Health Place. Author manuscript; available in PMC 2011 September 1.
Published in final edited form as:
PMCID: PMC2920044



We compared drug-related behaviors, including initiation of drug use, among street youth residing in two adjacent neighborhoods in Vancouver. One neighborhood, the Downtown Eastside (DTES), features a large open-air illicit drug market.

In multivariate analysis, having a primary illicit income source (Adjusted Odds Ratio [AOR] = 2.64, 95% Confidence Interval [CI]: 1.16 – 6.02) and recent injection heroin use (AOR = 4.25, 95% CI: 1.26 – 14.29) were positively associated with DTES residence, while recent non-injection crystal methamphetamine use (AOR: 0.39, 95% CI: 0.16 – 0.94) was negatively associated with DTES residence. In univariate analysis, dealing drugs (Odds Ratio [OR] = 5.43, 95% CI: 1.24 – 23.82) was positively associated with initiating methamphetamine use in the DTS compared to the DTES.

These results demonstrate the importance of considering neighborhood variation when developing interventions aimed at reducing drug related harms among street-involved youth at various levels of street entrenchment.

Keywords: street youth, crystal methamphetamine, initiation, injection drug use, drug dealing


Cities throughout the world are increasingly confronted with diverse health and social harms related to the use of illicit drugs (13). Commonly, these harms are most intense in areas where illicit drug markets are active (46), and studies have reported consistently high incidence of HIV and hepatitis C infection, incarceration, and fatal and non-fatal overdose among illicit drug-using individuals in urban centers that contain drug markets (7, 8). As a result, a variety of public health and law enforcement interventions have become clustered in urban illicit drug markets in an attempt to mitigate the negative impacts of illicit drug use and drug market involvement (9, 10).

Recent efforts to disentangle urban health harms have focused on how environmental phenomena help to define the risk environments experienced by vulnerable populations in specific geographic areas (11, 12). For example, researchers using spatial analysis in Kwazulu-Natal found that in a mixed urban-rural study setting, residency near the National Road, a major regional transit hub, was associated with a significantly higher risk of HIV infection (13). In the context of illicit drug use, research from Vancouver recently identified residency in the city’s downtown eastside (DTES), a low-income neighborhood that hosts one of North America’s largest open-air illicit drug markets, as independently associated with a twofold risk of HIV seroconversion among a cohort of injection drug users, despite adjustment for a variety of confounders (14). Further, researchers have demonstrated that geographic proximity to an illicit drug market, as well as neighborhood-level factors, help determine the severity and scope of drug- and health-related risks that illicit drug users may face (1517).

‘Entrenchment’ in this context refers to individuals that have become highly acculturated to life on the street, who employ street-based income generation activities (e.g., selling drugs, sex trade involvement, panhandling) as a primary source of income, and who report long-term homelessness or living in unstable housing situations (e.g., single-occupancy hotels or shelters) (18). Preventing illicit drug scene entrenchment is critical to the reduction of a variety of severe health risks, and experts have therefore urged a greater focus on research into the prevention of injection drug use initiation (19). Street youth are at particularly high risk of drug scene entrenchment and related risk behaviors such as the initiation of injection drug use (20), and exposure to an adult illicit drug injection scene has previously been shown to be associated with a variety of health harms among this population (4, 21).

Recent qualitative and ethnographic research conducted among a cohort of street youth in Vancouver suggests that a number of social and structural dynamics play a key role in increasing young people’s entrenchment in Vancouver’s local drug scene (2224). Further, these dynamics shape risk differently in the DTES compared with an adjacent area known as the Downtown South (DTS), which is Vancouver’s primary entertainment and retail district, and also features urban residential and financial zones (25). The DTS is characterized by mixed income housing, including an estimated 1,000 non-market housing units (25), and a more ‘closed’ drug scene than that found in the DTES, featuring younger individuals and those characterized by less intense involvement in street life (i.e., illicit income generation, long-term homelessness, and drug dependence) (23). The DTS is also adjacent to the West End, an affluent retail and residential district that youth in our setting often consider as an extension of the DTS (see Figure 1) (24). Previous research also suggests that illicit drug users in the DTS are younger, less-entrenched, and use crystal methamphetamine at higher rates compared with drug users in other neighbourhoods in Vancouver (26). Comparatively, the DTES is well-known as an open-air adult injecting scene, characterized by a large proportion of individuals that engage in high levels of crack use, injection heroin and cocaine use, illicit income generation, and who report high levels of unstable housing and homelessness (23). Compared with the British Columbia provincial average, the DTES also has a 33% increased mortality rate, and a higher proportion of male and Aboriginal residents. Further, life expectancy is 3 years lower than the provincial average among female DTES residents, and 9 years lower than the provincial average among male DTES residents (5). Drug-related deaths (i.e. overdose mortality) occur at 7 times the provincial rate in the DTES (5), and while rates of drug overdose have decreased in recent years, this phenomenon still represents one of the major leading causes of death in British Columbia (27, 28).

Fig. 1
Map of neighbourhoods.

Locally, concern exists that the proximity of the DTS to the DTES, coupled with the mobility of the city’s street youth population across these distinct neighborhoods, may contribute to a process of normalization of more intense drug-related harms (21). This process of normalization could in turn lead to increased uptake of injection drug use and higher levels of street entrenchment among youth residing in both areas (in spite of the fact that open injection drug use is far less prevalent in the DTS than in the DTES) (29). This concern is informed by research investigating the association between neighborhood-level influences and drug-related health risks (14, 16, 24, 30, 31). In particular, a large body of literature has demonstrated that the built environment affects the range of choices available to vulnerable populations such as street-involved youth (3236), particularly when considered within the context of the confluence of other social, structural, and policy factors within a broader risk environment (2, 37). Appropriate and stable housing, for example, is often not available to street-involved youth and may result in a reliance on social networks for stability (23). As such, the influence of these social networks may play a primary role in shaping decision-making among this population (22).

The scope and density of the illicit drug market in Vancouver’s DTES, as well as the presence of a large street youth population spread out across multiple neighborhoods, affords a unique opportunity to investigate how exposure to an adult drug market may shape risk among street youth. We therefore sought to further quantify the health, behavioral and drug-related risks experienced by street youth residing in the DTES and the DTS neighborhoods in Vancouver, and to investigate geographic correlates of drug use initiation (i.e., crystal methamphetamine use) and drug market involvement among a street youth sample.


All data for these analyses were conducted using data from the At-Risk Youth Study (ARYS), a Vancouver-based cohort study of street youth aged 14 to 26 (38). ARYS participants are recruited using street outreach and self-referral, and eligible study participants reported using illicit drugs other than marijuana in the last 30 days. Once recruited, participants complete an interviewer-administered questionnaire and a physical and mental health assessment that includes blood samples for diagnostic testing. Thereafter, participants return to complete the interviewer-administered questionnaire semi-annually. Participants are provided with a $20 CND honorarium. The ARYS questionnaire solicits detailed demographic data as well as data on drug use behaviors, income sources, housing situation, experiences with incarceration, involvement in the sex trade and the illicit drug trade, and perceptions of the efficacy and accessibility of health and social services. The study has been approved by the University of British Columbia/Providence Health Care Ethics Review Board, and all study participants provide written consent prior to enrolment.

For the present study, data were collected from participant interviews conducted between September 1, 2005 and December 31, 2007. Because we were interested in comparing drug-related behaviors and health risks among street youth in two well characterized neighborhoods (those in the DTES with those in the DTS), we restricted our sample to ARYS participants who reported currently residing in either of these two areas, and residency in the DTES vs. the DTS constituted our dependent dichotomous variable of interest. Our selection of independent variables of interest was informed by previous qualitative and quantitative analyses of illicit drug use conducted among vulnerable populations in our study setting (23, 3840), and included the following: age, gender, ethnicity (Aboriginal vs. other), homelessness, amount of money spent on drugs per day ($50 or less vs. more than $50), having a primarily licit vs. illicit source of income, dealing drugs, recent crack smoking, recent non-injection crystal methamphetamine use, recent injection heroin use, recent injection cocaine use, recent injection crystal methamphetamine use, preferred location of illicit drug purchases (DTES vs. DTS vs. all other areas), unsafe sex (i.e., unprotected vaginal or anal sexual intercourse excluding commercial sex work), involvement in the commercial sex trade, having been assaulted, and being stopped, searched or detained by police. All behavioral variables refer to the 6 months prior to the participant interview. The variables selected for inclusion in the model represent commonly used identifiers of drug-related health harms, unstable housing situations, and involvement in street-based drug market scenes. Our statistical model therefore allows for the investigation of levels of health risks and street entrenchment among participants residing in each neighbourhood of interest.

We conducted univariate logistic regression analyses to determine factors associated with current neighborhood of residence (DTES vs. DTS). Categorical and explanatory variables were analyzed using Pearson’s X2, while continuous variables found to be normally distributed were analyzed using t-tests for independent samples, and continuous variables found to be skewed were analyzed using Mann-Whitney U tests. Variables found to be associated with the outcome of interest at p ≤ 0.05 were then considered in a fixed multivariate logistic regression model. Finally, we solicited data on circumstances surrounding first injection drug use and first crystal methamphetamine use experiences among study participants residing in the DTES or the DTS. We then conducted separate univariate logistic regression subanalyses to determine factors associated with the initiation of crystal methamphetamine among our cohort participants. In this subanalysis, participants were asked, “the first time you used crystal meth, what neighbourhood were you in?” All statistical analyses were performed using SPSS software version 17.0 (SPSS, Chicago, IL).


Overall, 222 street youth participated in the present study, including 65 (29.3%) women and 51 (23.0%) individuals who self-identified as Aboriginal. Median participant age was 23.6 years old (Interquartile Range: 20.1 – 27.1). Overall, 155 (69.8%) participants reported currently residing in the DTS, while 67 (30.2%) reported currently residing in the DTES. Further, 26 (38.8%) of those participants residing in the DTES reported injection drug use in the last 6 months, while 37 (23.8%) of those residing in the DTS reported such use in the last 6 months. Drug dealing among street youth occurred at comparably high levels among participants in both neighborhoods (DTS: 74.8%; DTES: 85.1%; p = 0.091).

Tables 1 and and22 present the results of our univariate analyses of sociodemographic, behavioral, and drug use variables associated with current neighborhood of residence. Table 3 presents the results of the multivariate analysis and, as can be seen, after intensive adjustment for potential confounders, reporting an illicit primary income source (Adjusted Odds Ratio [AOR] = 2.64, 95% Confidence Interval [CI]: 1.16 – 6.02, p = 0.021), injection heroin use (AOR = 4.25, 95% CI: 1.26 – 14.29, p = 0.019), and preferring to buy drugs in the DTES vs. the DTS (AOR = 6.93, 95% CI: 3.83 – 12.52, p < 0.001) were all independently associated with residence in the DTES. Further, non-injection crystal methamphetamine use (AOR = 0.39, 95% CI: 0.16 – 0.94, p = 0.037) was negatively associated with residing in the DTES.

Table I
Univariate analysis of sociodemographic and behavioural factors associated with neighbourhood of residence among street youth in Vancouver (n = 222)
Table II
Univariate analysis of drug use behaviors associated with neighborhood of residence among street youth in Vancouver (n = 222)
Table III
Multivariate logistic regression analysis of factors associated with residence in the DTES vs. the DTS neighborhood among a cohort of street youth in Vancouver (n = 222)

Overall, 64 (28.8%) participants reported previously initiating injection drug use. Of these, 10 (24.4%) participants reported first injecting drugs in the DTES, while 20 (48.8%) reported first injecting drugs in the DTS. Further, among 72 (32.4%) participants who reported initiating crystal methamphetamine use, 43 (59.7%) reported initiating crystal methamphetamine use in the DTS, while 12 (16.7%) reported doing so in the DTES.

Finally, in a univariate logistic regression subanalysis, reporting initiating of methamphetamine use in the DTS compared with the DTES was significantly associated with reporting dealing drugs (OR = 5.43, 95% CI: 1.24 – 23.82, p = 0.030).


Among a cohort of street youth, levels of initiation of injection drug use were over twice as high in the DTS than levels reported by youth residing in the DTES. We also found that study participants residing in the DTES were significantly more likely to report having an illicit primary income source, report engaging in injection heroin use, and report preferring to buy drugs in the DTES compared with participants residing in the DTS. However, study participants living in the DTS were significantly more likely to engage in non-injection crystal methamphetamine use. Of concern, study participants reported initiating injection drug use in the DTS at a level twice as high compared with the DTES, and the initiation of crystal methamphetamine use was reported among study participants in the DTS at a level almost four times as high as the level of initiation reported in the DTES. Finally, in univariate analysis, individuals reporting initiating methamphetamine use in the DTS were more likely to report dealing drugs than those that reported initiating methamphetamine use in the DTES.

While preliminary, these results are surprising since we expected that residency within the DTES, which includes a large open-air illicit drug market, would be associated with substantially greater drug-related health risks. That we observed non-significant risks for a variety of types of drug use as well as for involvement in drug dealing and the sex trade between street youth residing in the DTS and the DTES may suggest that interventions to reduce youth entrenchment in an open-air illicit drug market should take into consideration the role of adjacent neighborhood street scenes in influencing drug use patterns (21). Specifically, while we found that participants residing in the DTES were more likely than those in the DTS to report having a primary illicit income source, we found no significant differences in risk of drug dealing, as well as comparably high levels of this illicit activity, among individuals residing in both neighborhoods. These reported high levels are consistent with previous research in our study setting, which found that 79% of a sample of street-involved youth reported selling drugs, while 86% reported that they were involved in the drug trade in order to generate income for their personal drug use (40). It is also of note that in univariate analysis, drug dealing was associated with reporting initiating crystal methamphetamine use in the DTS. While caution is warranted in the interpretation of univariate results, these data may suggest that the initiation of crystal methamphetamine by youth residing in the DTS signals an immersion into a street-based illicit drug scene, and may therefore represent a potential interventional point for the prevention of street entrenchment among youth. Taken alongside the findings of our multivariate analysis and previous qualitative work from our study setting, these results suggest that the DTS may be an introductory area for those youth drawn towards street-involvement and may uniquely facilitate transitions to the development of more intense risk behaviors as observed among youth in the DTES (21). This phenomenon may also be a product of the socio-historical context of drug use, illicit drug culture, and policy responses in the city of Vancouver. Beginning in the 1950s, the DTES began to transform from Vancouver’s premier retail, administration, and entertainment district into an area now better known as a low-income setting marked by high levels of injection drug use (41). This characterization has continued for decades, and has resulted in a commonly held perception of the DTES as a ‘closed’ space (23). While the results of our study are limited, it is possible that this perception of the DTES may discourage novice street-involved youth from initially residing in that area (23). For example, previous research in our study setting has hypothesized that non-injection crystal methamphetamine use may be predictive of the initiation of injection drug use among street youth (38), and as noted above we found that study participants initiated crystal methamphetamine use at much higher levels in the DTS compared with the DTES. While the DTES is the site of a variety of programs servicing that neighborhood’s large polydrug-using community, the street youth population in the DTS may contain a high number of individuals who are newly-recruited to street involvement and highly vulnerable to street entrenchment and initiation of injection drug use (21). This is particularly pertinent given that public health experts have suggested prioritizing the prevention of injection drug use among vulnerable populations (19).

These preliminary results build on previous research on geographic factors associated with drug market entrenchment and suggest areas of future research. Observers have noted the ways in which geographic migration can modify health risks among vulnerable populations in a variety of settings (4244). While this research is often focused regionally, our findings suggest that considering micro-setting and intra-city migration may also be useful in identifying key opportunities for the reduction of risk for HIV and other blood-borne disease infection, the initiation of injection drug use, and street entrenchment. For example, the sexual transmission of HIV infection in southern Africa has been linked to the migration of laborers and the expansion of commercial sex trade work along the transit routes connecting South Africa to its neighboring countries (44, 45). As a result, policymakers have therefore targeted these particular transit routes for preventive campaigns to reduce sexual transmission of HIV (46).

While little data exist regarding migration patterns among street-involved youth in Vancouver, a previous qualitative study reported that the majority of youth participants migrated from other Canadian cities in order to escape negative situations with law enforcement, while a minority indicated that they grew up ‘on the streets’ of Vancouver’s downtown (23). In our study setting, like many other urban communities, street involvement appears to facilitate a range of high-risk behaviors among youth. Perhaps most relevant is our finding that participants report initiating crystal methamphetamine use at much higher levels in the DTS compared with the DTES. In this context, it is important to note that the DTS’ geographic proximity to the DTES and the mobility of street youth across these two areas appears to create a permeability that may facilitate further street entrenchment among youth in our study. While age-appropriate outreach and treatment services are available for youth in both the DTS and the DTES (47), the utility of these services to newly-recruited street-involved youth may be limited, given that research suggests that such populations have minimal uptake of treatment services (48). Further, both the DTS and the DTES suffer from a dearth of youth-targeted structural interventions such as assisted housing and harm reduction shelters (22). For example, qualitative research from our study setting has demonstrated that street-involved youth residing in downtown Vancouver reported that inflexible shelter rules and the stigma and lack of safety associated with single-room occupancy hotels outweighed the benefits of sleeping indoors. In turn, this lack of appropriate housing greatly increases the risk of further entrenchment within a street-based illicit drug scene (22). Given that public health experts have suggested prioritizing the prevention of injection drug use among vulnerable populations (19), the implementation of interventions to address the built environment, particularly among newly-recruited street-involved youth in the DTS, is needed.

Our study has a number of important limitations. First, we are unable to infer causal associations between reported neighborhood of residence and the risk behaviors that we analyzed as a result of the cross sectional nature of our analyses. Specifically, we were unable to elucidate the mechanisms by which neighborhood of residence modifies risk, though it is noteworthy that previous qualitative investigations of such mechanisms are consistent with our current findings (23, 24). Further, we are unable to determine the causal direction between reported residence in each neighbourhood of interest and the drug use patterns reported by study participants. It is noteworthy, however, that previous research conducted in our study setting suggests that drug use behaviours may be the result of immersion within social networks and illicit drug scenes unique to each neighbourhood of interest (23). Second, ARYS is not a random sample and its generalizability to other samples of street youth may therefore be limited. Third, because we relied primarily on self-report, risk behaviors among study participants may have been underreported as a result of social stigma (49). Fourth, while we based our analyses on previous research conducted among street-involved youth in our study setting and were therefore able to confirm that our current findings were consistent with previous analyses, it is possible that we were still unable to adjust for all variables that may have contributed to the differences that we observed between participants residing in the neighborhoods of interest. In this regard, it is important to note that the low power in our sample excluded the possibility of controlling for factors in our subanalysis of crystal methamphetamine initiation, and these results in particular should therefore be interpreted with caution. Finally, while youth participating in the study reported on neighbourhood of residence, it is possible given the transient nature of this population that some youth may have migrated between areas. This may have resulted in an underestimate of the risk factors reported by each neighbourhood subsample.

Our findings suggest that while the DTES remains the epicenter of drug market activity among our sample, the adjacent DTS neighborhood may play a key role in the transition among street youth from lower-risk street involvement to high-risk street entrenchment, and may also be an important site of initiation into crystal methamphetamine. As well, on a number of indicators of drug-related behaviors, no differences existed between street youth residing in the DTES and those residing in the more affluent DTS. These results suggest that future research is needed to investigate whether neighborhoods peripheral to illicit drug markets are sites of increased risk for drug use initiation and entrenchment within adult drug injecting scenes.


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