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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Clin Nutr. Author manuscript; available in PMC 2011 October 1.
Published in final edited form as:
Clin Nutr. 2010 October; 29(5): 605–609.
Published online 2010 April 9. doi:  10.1016/j.clnu.2010.03.005
PMCID: PMC2919604

Nut Consumption and Risk of Stroke in US Male Physicians


Background and Aims

While nut consumption has been shown to lower the risk of hypertension and coronary disease, it is not known whether nut consumption is associated with the risk of stroke. We sought to examine whether nut consumption is associated with total and subtypes of stroke.


Prospective cohort of 21,078 participants from the Physicians’ Health Study (1982–2008) who were free of stroke at baseline. Nut consumption was assessed using a simple 19-item food questionnaire and stroke cases were confirmed after reviewing medical records. We used Cox proportional hazards regression to estimate relative risks of total, ischemic, and hemorrhagic stroke according to consumption of any nuts.


During a mean follow up of 21.1 years, 1,424 incident cases of stroke occurred (219 hemorrhagic, 1,189 ischemic, and 16 of undetermined cause). There was no statistically significant association between nut consumption and total or ischemic stroke. In contrast, there was a suggestive non-linear relation between nut intake and hemorrhagic stroke: compared to subjects who did not consume nuts, multivariable adjusted hazard ratios (95% CI) for hemorrhagic stroke for subjects consuming nuts < 1, 1, 2–4, 5–6, and ≥ 7 times/week were 1.13 (0.78–1.62), 1.05 (0.70–1.58), 0.49 (0.27–0.89), 1.50 (0.79–2.84), and 1.84 (0.95–3.57), respectively (p for quadratic trend 0.12).


Our data showed no association between nuts and ischemic stroke and suggested a J-shaped relation between nut consumption and hemorrhagic stroke. Replication of our findings in the general population is warranted.

Keywords: Diet, stroke, epidemiology, nuts, nutrition


Despite a decline in the rate of stroke in the US1,2, it remains a major public health issue and is associated with disability, mortality, and major direct and indirect costs3,4. This underscores the importance of prevention strategies aiming at reducing the incidence of stroke given the limited acute treatment options. Hypertension is a major risk factor for stroke5 and can be influenced by modifiable lifestyle factors including diet. Among dietary factors, nuts are important source of macro- and micronutrients with health benefits6 as they are low in sodium and also contain a variety of nutrients including unsaturated fatty acids, and minerals such as magnesium and potassium. Previous studies have suggested that nuts may have beneficial effects on blood pressure79, lipids10,11, and insulin sensitivity12. In a feeding trial, a Mediterranean diet enriched with 30 g/d of nuts (walnuts −15 g/d, hazelnuts −7.5 g/d, and almonds −7.5 g/d) was associated with reduced blood pressure compared to low-fat diet13. We have previously reported an inverse relation between nut intake and hypertension in male physicians14. It is thus possible that these physiologic effects of nuts may confer a lower risk of stroke among people who consume them on a regular basis. However, there is a lack of data on the relation between nut consumption and the risk of total stroke or stroke subtypes. Since omega-3 fatty acids contained in nuts have been shown to inhibit platelet aggregation15,16, it is possible that nut consumption may prevent or attenuate the progression of thrombo-embolic events. The current study sought to prospectively examine whether nut consumption is associated with the risk of total stroke and stroke subtypes.

Materials and Methods

Study population

Participants in this project were drawn from the Physicians’ Health Study (PHS), which is a completed randomized, double-blind, placebo-controlled trial designed to study low-dose aspirin and beta-carotene for the primary prevention of cardiovascular disease and cancer. A detailed description of the PHS has been published previously17. Each participant gave written informed consent and the Institutional Review Board at Brigham and Women’s Hospital approved the study protocol. Of the total 22,071 participants, we excluded 615 subjects because of missing data on nut consumption, 22 subjects who reported stroke diagnosis prior to receiving the 12 months post-randomization when nut consumption was assessed, 3 cases of unrefuted stroke, 353 people with missing covariates (body mass index, smoking, breakfast cereal, alcohol intake, fruit and vegetable consumption, or exercise). Thus, a final sample of 21,078 subjects was used for current analyses.

Assessment of nut consumption

Information on nut consumption was self-reported using a 19-item semi-quantitative food frequency questionnaire administered 12 months post-randomization (1983–1985). Participants were asked to indicate “how often, on average, they have eaten nuts (small packet or 1 oz.)”. Possible response categories included “rarely/never”, “1–3/month”, “1/week”, “2–4/week”, “5–6/week”, “daily”, and “2+/day”. Due to limited number of participants in each of the last 2 highest categories, we combined any nut consumption of ‘daily” and “2+/d” to obtain stable estimates (subsequently referred to as ≥ 7 /week). Although the food frequency questionnaire was not validated in the PHS I, it has been validated in several cohorts18,19. While the questionnaire asked about peanut butter use, no data were collected on the specific type of nuts consumed.

Ascertainment of stroke

Detailed description of ascertainment of stroke in the PHS has been published previously20. Briefly, information of incident stroke was collected through yearly follow-up questionnaires. For subjects who reported stroke on a follow-up questionnaire, we asked permission to obtain their medical records. An end points committee confirmed a diagnosis of a stroke after review of medical records. Non-fatal stroke was defined as a focal neurological deficit of sudden or rapid onset lasting more than 24 hours and was classified according to criteria established by the National Survey of Stroke21 into ischemic, hemorrhagic (including intraparenchymal and subarachnoid hemorrhage), and unknown subtypes, using available information in the medical records including brain imaging22. Fatal strokes were confirmed by review of autopsy reports, death certificates, medical records, or information from the next of kin or family members.

Other variables

Demographic data were collected at baseline. At 12 months post-randomization (when nut consumption was assessed), information on prevalent angina pectoris, myocardial infarction, coronary angioplasty and revascularization, atrial fibrillation, type 2 diabetes, and hypertension was collected. Hypertension was defined as systolic blood pressure of at least 140 mm Hg or diastolic blood pressure of at least 90 mm Hg, treatment for hypertension, or spontaneous self-reports of hypertension. Data on selected foods such as fruits and vegetables, breakfast cereal; physical activity; smoking; alcohol consumption; liver intake; and low fat and whole milk were obtained through self-reports at baseline. For subjects with missing information on breakfast cereal at baseline, we used breakfast cereal information collected at 24 months. Additional information on selected foods including fish, red meat, ice cream, cheese, chicken, and turkey was collected. We assigned the mid-point of the response category as outlined for nuts above to each response category and summed up subcategories within each food group (i.e. low fat milk, yogurt, and cheese for dairy; dark meat fish, tuna, shrimp, and other fish for fish; and beef, pork, lamb, and hotdogs for red meat). For “2+/day” category, we assigned a value of 14 times per week.

Statistical analyses

We classified each subject into one of the following categories of nut consumption: 0, < 1, 1, 2–4, 5–6, and ≥ 7 times per week. We computed person-time of follow up from exposure assessment (12 months post-randomization) until the first occurrence of a) stroke, b) death, or c) date of receipt of last follow-up questionnaire (March 2008). For each category of nut consumption, incidence rate was computed by dividing the number of cases by the corresponding person-time of follow up. We used Cox proportional hazards models to compute multivariable-adjusted hazard ratios with corresponding 95% confidence intervals using subjects reporting no nut consumption as the reference group. We assessed confounding smoking, alcohol intake, hypertension, aspirin assignment, diabetes, body mass index, regular exercise, and consumption of breakfast cereal, dairy products, fruits and vegetables, fish, and red meat using the 10% change in estimate of effect23. The fully adjusted model controlled for age, body mass index (<25, 25–29, 30 kg/m2), smoking (never, former, current smoker), aspirin arm (yes/no), fruit and vegetable intake (<3, 3–4, 5–6, 7–13, 14+ servings per week), alcohol consumption (<1, 1–4, 5–7, and 8+ drinks/week), breakfast cereal (0, ≤ 1, 2–6, and 7+/week), red meat (quintiles), fish (up to 1, 2, 3, and 4+ servings/week), dairy (quintiles), exercise (2+/week vs. ≤ 1 per week), and prevalent hypertension, diabetes, atrial fibrillation, and coronary heart disease (angina pectoris, myocardial infarction, coronary bypass or angioplasty). We analyzed total stroke, ischemic stroke, and hemorrhagic stroke separately. Assumptions for proportional hazard models were tested (by including main effects and product terms of covariates and logarithmic transformed time factor) and were met (all p values >0.05). We also conducted sensitivity analyses excluding subjects with follow-up time of less than 2 years (n=235) to allow sufficient window between exposure and outcome. Furthermore, we repeated analyses with follow-up time restricted to 5 and 10 years with the rationale that within a shorter period of time, individuals are less likely to change their frequency of nut consumption. All analyses were completed using SAS, version 9.1 (SAS Institute, NC). Significance level was set at alpha=0.05, two-tailed p values.


Table 1 presents the crude baseline characteristics of 21,078 study participants according to categories of nut consumption. The mean age was 54.6±9.5 years (range 40.7 to 86.7). Higher consumption of nuts was associated with a lower prevalence of diabetes and atrial fibrillation, and a higher proportion of fruit and vegetable, fish, dairy, and breakfast cereal consumption. During the follow up, 1,424 new cases of stroke occurred (1,189 ischemic, 219 hemorrhagic, and 16 of undetermined cause). Table 2 provides characteristics of subjects with stroke and those without stroke. In a crude analysis, there was a non-linear inverse relation between nut consumption and total stroke (p for quadratic trend 0.001, Table 3). However, adjustment for potential confounders in a multivariable model completely eliminated this association (Table 3). There was no evidence for an association between nut consumption and ischemic stroke after adjustment for potential confounders (Table 3). In contrast, there was a suggestive J-shaped relation between nut intake and hemorrhagic stroke with the lowest hazard ratio among people consuming 2–4 times /week (HR: 0.49; 95% CI: 0.27–0.89) and the highest hazard ratio in subjects consuming 7 or more servings of nuts per week [HR (95% CI): 1.84 (0.95–3.57)], P for quadratic trend 0.10, Table 3. Exclusion of subjects with follow up time below 2 years did not appreciably alter the results (data not shown). Furthermore, restriction of follow up to 5 or 10 years did not alter the findings (data not shown).

Table 1
Baseline characteristics of 21,078 US male physicians according to nut consumption
Table 2
Baseline characteristics of 21,078 US male physicians according to incident stroke
Table 3
Hazard ratios (95% CI) for hemorrhagic, ischemic, and total stroke according to nut consumption


In this large prospective cohort of apparently healthy men at baseline, we found no evidence for an association between nut consumption and the risk of total or ischemic stroke after an average follow up of 21.1 years. For hemorrhagic stroke, we observed suggestive evidence for a J-shaped relation with nut consumption. Despite advances in medical and surgical treatment, stroke is still associated with major disability and is the 3rd leading cause of death. This underscores the importance of preventive measures for this disease. Several dietary factors have shown beneficial effects on stroke predictors. Data from the PREDIMED trial showed that compared with a low-fat diet, Mediterranean diets supplemented with 30 g/d of nuts (almonds, hazelnuts, and walnuts) and olive oil were associated with 7.1 and 5.9 mm Hg reduction in systolic blood pressure after 3 months of intervention, respectively, among ~257 adult men and women per intervention group13. In that study, corresponding effects for diastolic blood pressure were 2.6 and 1.6 mm Hg for Mediterranean diet with nuts and olive oil13, respectively. Nut consumption may lower the risk of stroke via its beneficial effects on blood pressure or other predictors of stroke. Nut consumption has been associated with improved lipid profile2428, insulin sensitivity12,29, and reduced inflammation6,13,30. However, our data on total and ischemic stroke do not support this hypothesis.

The J-shaped relation observed between nut consumption and hemorrhagic stroke merits some comments. We had limited number of stroke in the higher categories of nut consumption. Consequently our data should be interpreted with caution. However, it is possible that omega-3 fatty acids contained in nuts may be partially responsible for the observed increased risk of hemorrhagic stroke with consumption of nuts 5 or more times per week. Previous studies have demonstrated that polyunsaturated fatty acids found in nuts may inhibit platelet aggregation 15,16. This may increase the propensity to bleeding. In a necropsy study in Greenland, the concentration of total n-3 polyunsaturated fatty acids in perirenal adipose tissue was higher (2.3 units) in 4 cases of fatal hemorrhagic stroke than in 26 subjects without cerebral pathology (1.5 units)31. In contrast, the Cardiovascular Health Study32 and the Health Professional Follow-up Study33 did not find a statistically significant association between fish intake and hemorrhagic stroke. Of note is that n-3 fatty acids only affect bleeding times at higher concentrations (3–15 g/d)34,35. The lower intake of fish in the Western diet compared with Greenland Inuit may partially account for the inconsistency in these findings. Lastly, it is possible that people with a lifestyle considered healthy for ischemic stroke may be at increased risk for hemorrhagic stroke36. For example, subjects with low body mass index and low LDL-cholesterol have been reported to have a higher risk of hemorrhagic stroke37.

Strengths of the present paper are the large sample size, large number of outcomes events, the long duration of follow up, and the ascertainment of stroke through review of medical records. However, our study has some limitations. While the number of stroke events is large, the number of stroke subtypes according to nut consumption categories is relatively small. Thus, the statistically significant results for hemorrhagic stroke should be interpreted with caution. The generalizability of our findings is limited by the fact that all participants were male physicians who may have different behaviors or lifestyle habits than the general population. Nut consumption was assessed only once (12 months post-randomization) and since subjects may have changed their dietary habits, we were not able to account for such changes in our analyses. Such misclassification may bias the results towards the null and may partially explain the lack of an association between nuts and ischemic stroke in this study. However, the fact that we have shown an inverse relation between nuts assessed at one single time point and incident hypertension14 in the same cohort does not support the hypothesis of a large misclassification of nuts over time in this population. In addition, our findings on ischemic stroke did not change when we restricted the follow-up time to 5 or 10 years (a period within which one could assume little change in nut consumption). Since we used a simple questionnaire to assess nut consumption, we were unable to adjust for total energy intake and other nutrients consumed by study subjects. In addition, we did not have data on types of nuts consumed; their preparation including salted, spiced, roasted, or raw nuts to examine the influence of types of nuts or preparation method on the risk of total stroke and stroke subtype. The prevalence of atrial fibrillation was higher in stroke cases than in non-cases, suggesting that the use of warfarin might have been more prevalent in people with stroke. Such use of anticoagulant may have confounded the association between nut consumption and hemorrhagic stroke. Although we did not have information on warfarin use for further evaluation, we did adjust for atrial fibrillation (more likely to be correlated with warfarin use during follow up). Lastly, given the observational design of the present study, we can not exclude unmeasured or residual confounding as a possible explanation for observed findings.

In conclusion, our data suggest no association between nut consumption and total or ischemic stroke. However, there is suggestive J-shaped relation between nut consumption and hemorrhagic stroke. Since we had limited number of hemorrhagic strokes in the highest categories of nut consumption, replication of our findings is other populations along with assessment of types of nuts consumed and underlying physiologic mechanisms are warranted.


We are indebted to the participants in the PHS for their outstanding commitment and cooperation and to the entire PHS staff for their expert and unfailing assistance.

Funding: The Physicians’ Health Study is supported by grants CA-34944, CA-40360, CA-097193, HL-26490, HL-34595 from the National Institute of Health, Bethesda, MD.


Conflict of interest:

None to disclose.


1. Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, et al. Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008;117:e25–e146. [PubMed]
2. Carandang R, Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Kannel WB, et al. Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years. JAMA. 2006;296:2939–2946. [PubMed]
3. Taylor TN, Davis PH, Torner JC, Holmes J, Meyer JW, Jacobson MF. Lifetime cost of stroke in the United States. Stroke. 1996;27:1459–1466. [PubMed]
4. Diringer MN, Edwards DF, Mattson DT, Akins PT, Sheedy CW, Hsu CY, et al. Predictors of acute hospital costs for treatment of ischemic stroke in an academic center. Stroke. 1999;30:724–728. [PubMed]
5. Park JK, Kim CB, Kim KS, Kang MG, Jee SH. Meta-analysis of hypertension as a risk factor of cerebrovascular disorders in Koreans. J Korean Med Sci. 2001;16:2–8. [PMC free article] [PubMed]
6. Kris-Etherton PM, Hu FB, Ros E, Sabate J. The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. J Nutr. 2008;138:1746S–1751S. [PubMed]
7. Ferrara L, Raimondi S, d'Episcopo L, Guida L, Dello Russo A, Marotta T. Olive oil and reduced need for antihypertensive medications. Arch Intern Med. 2000;160:837–842. [PubMed]
8. Brancati FL, Appel LJ, Seidler AJ, Whelton PK. Effect of potassium supplementation on blood pressure in African Americans on a low-potassium diet. A randomized, double-blind, placebo-controlled trial. Arch Intern Med. 1996;156:61–67. [PubMed]
9. Myers VH, Champagne CM. Nutritional effects on blood pressure. Curr Opin Lipidol. 2007;18:20–24. [PubMed]
10. Tapsell LC, Gillen LJ, Patch CS, Batterham M, Owen A, Bare M, et al. Including walnuts in a low-fat/modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes. Diabetes Care. 2004;27:2777–2783. [PubMed]
11. Jenkins DJ, Kendall CW, Marchie A, Parker TL, Connelly PW, Qian W, et al. Dose response of almonds on coronary heart disease risk factors: blood lipids, oxidized low-density lipoproteins, lipoprotein(a), homocysteine, and pulmonary nitric oxide: a randomized, controlled, crossover trial. Circulation. 2002;106:1327–1332. [PubMed]
12. Jiang R, Manson JE, Stampfer MJ, Liu S, Willett WC, Hu FB. Nut and peanut butter consumption and risk of type 2 diabetes in women. JAMA. 2002;288:2554–2560. [PubMed]
13. Estruch R, Martinez-Gonzalez MA, Corella D, Salas-Salvado J, Ruiz-Gutierrez V, Covas MI, et al. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med. 2006;145:1–11. [PubMed]
14. Djousse L, Rudich T, Gaziano JM. Nut consumption and risk of hypertension in US male physicians. Clin Nutr. 2008;88:930–933. [PMC free article] [PubMed]
15. Connor SL, Connor WE. Are fish oils beneficial in the prevention and treatment of coronary artery disease? Am J Clin Nutr. 1997;66:1020S–1031S. [PubMed]
16. Mutanen M, Freese R. Polyunsaturated fatty acids and platelet aggregation. Curr Opin Lipidol. 1996;7:14–19. [PubMed]
17. Final report on the aspirin component of the ongoing Physicians' Health Study. Steering Committee of the Physicians' Health Study Research Group. N Engl J Med. 1989;321:129–135. [PubMed]
18. Rimm EB, Giovannucci EL, Stampfer MJ, Colditz GA, Litin LB, Willett WC. Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol. 1992;135:1114–1126. [PubMed]
19. Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, et al. Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol. 1985;122:51–65. [PubMed]
20. Kurth T, Gaziano JM, Berger K, Kase CS, Rexrode KM, Cook NR, et al. Body mass index and the risk of stroke in men. Arch Intern Med. 2002;162:2557–2562. [PubMed]
21. Walker AE, Robins M, Weinfeld FD. The National Survey of Stroke. Clinical findings. Stroke. 1981;12:I13–I44. [PubMed]
22. Berger K, Kase CS, Buring JE. Interobserver agreement in the classification of stroke in the physicians' health study. Stroke. 1996;27:238–242. [PubMed]
23. Rothman KJ, Greenland S. Modern Epidemiology. Lippincott Williams & Wilkins; 1998.
24. Sabate J, Fraser GE, Burke K, Knutsen SF, Bennett H, Lindsted KD. Effects of walnuts on serum lipid levels and blood pressure in normal men. N Engl J Med. 1993;328:603–607. [PubMed]
25. Lovejoy JC, Most MM, Lefevre M, Greenway FL, Rood JC. Effect of diets enriched in almonds on insulin action and serum lipids in adults with normal glucose tolerance or type 2 diabetes. Am J Clin Nutr. 2002;76:1000–1006. [PubMed]
26. Almario RU, Vonghavaravat V, Wong R, Kasim-Karakas SE. Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. Am J Clin Nutr. 2001;74:72–79. [PubMed]
27. Kris-Etherton PM, Yu-Poth S, Sabate J, Ratcliffe HE, Zhao G, Etherton TD. Nuts and their bioactive constituents: effects on serum lipids and other factors that affect disease risk. Am J Clin Nutr. 1999;70:504S–511S. [PubMed]
28. Griel AE, Kris-Etherton PM. Tree nuts and the lipid profile: a review of clinical studies. Br J Nutr. 2006;96 Suppl 2:S68–S78. [PubMed]
29. Wien MA, Sabate JM, Ikle DN, Cole SE, Kandeel FR. Almonds vs complex carbohydrates in a weight reduction program. Int J Obes Relat Metab Disord. 2003;27:1365–1372. [PubMed]
30. Jenkins DJ, Kendall CW, Marchie A, Faulkner DA, Josse AR, Wong JM, et al. Direct comparison of dietary portfolio vs statin on C-reactive protein. Eur J Clin Nutr. 2005;59:851–860. [PubMed]
31. Pedersen HS, Mulvad G, Seidelin KN, Malcom GT, Boudreau DA. N-3 fatty acids as a risk factor for haemorrhagic stroke. Lancet. 1999;353:812–813. [PubMed]
32. Mozaffarian D, Longstreth WT, Jr., Lemaitre RN, Manolio TA, Kuller LH, Burke GL, et al. Fish consumption and stroke risk in elderly individuals: the cardiovascular health study. Arch Intern Med. 2005;165:200–206. [PMC free article] [PubMed]
33. He K, Rimm EB, Merchant A, Rosner BA, Stampfer MJ, Willett WC, et al. Fish consumption and risk of stroke in men. JAMA. 2002;288:3130–3136. [PubMed]
34. Knapp HR. Dietary fatty acids in human thrombosis and hemostasis. Am J Clin Nutr. 1997;65:1687S–1698S. [PubMed]
35. Knapp HR, Reilly IA, Alessandrini P, FitzGerald GA. In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis. N Engl J Med. 1986;314:937–942. [PubMed]
36. Kurth T, Moore SC, Gaziano JM, Kase CS, Stampfer MJ, Berger K, et al. Healthy lifestyle and the risk of stroke in women. Arch Intern Med. 2006;166:1403–1409. [PubMed]
37. Knekt P, Reunanen A, Aho K, Heliovaara M, Rissanen A, Aromaa A, et al. Risk factors for subarachnoid hemorrhage in a longitudinal population study. J Clin Epidemiol. 1991;44:933–939. [PubMed]