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Logo of jcinvestThe Journal of Clinical Investigation
J Clin Invest. 1971 March; 50(3): 492–499.
PMCID: PMC291955

On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog


Healthy adult dogs were subjected to stepwise reduction of nephron population so as to create the transition from normal renal function to advanced renal insufficiency. Studies were performed at each level of renal function. Glomerular filtration rate (GFR), renal phosphate clearance, and serum radioimmunoassayable parathyroid hormone (PTH) levels were measured. Two groups of animals were studied. In one, phosphorous intake was maintained at 1200 mg/day. As GFR declined, fractional phosphate excretion rose reciprocally, and PTH levels increased over 20-fold. In the second group, phosphorous intake was maintained at less than 100 mg/day. As GFR fell, fractional phosphate excretion changed little, and no increment in PTH levels occurred. The data suggest that the control system regulating phosphate excretion contributes importantly to the pathogenesis of secondary hyperparathyroidism in advancing renal insufficiency.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • STANBURY SW. Azotaemic renal osteodystrophy. Br Med Bull. 1957 Jan;13(1):57–60. [PubMed]
  • POLLAK VE, SCHNEIDER AF, FREUND G, KARK RM. Chronic renal disease with secondary hyperparathyroidism. AMA Arch Intern Med. 1959 Feb;103(2):200–218. [PubMed]
  • Kleeman CR, Better O, Massry SG, Maxwell MH. Divalent ion metabolism and osteodystrophy in chronic renal failure. Yale J Biol Med. 1967 Aug 1;40(1):1–45. [PMC free article] [PubMed]
  • Slatopolsky E, Gradowska L, Kashemsant C, Keltner R, Manley C, Bricker NS. The control of phosphate excretion in uremia. J Clin Invest. 1966 May;45(5):672–677. [PMC free article] [PubMed]
  • Slatopolsky E, Robson AM, Elkan I, Bricker NS. Control of phosphate excretion in uremic man. J Clin Invest. 1968 Aug;47(8):1865–1874. [PMC free article] [PubMed]
  • Bricker NS, Slatopolsky E, Reiss E, Avioli LV. Caclium, phosphorus, and bone in renal disease and transplantation. Arch Intern Med. 1969 May;123(5):543–553. [PubMed]
  • Schultze RG, Shapiro HS, Bricker NS. Studies on the control of sodium excretion in experimental uremia. J Clin Invest. 1969 May;48(5):869–877. [PMC free article] [PubMed]
  • Moore EW. Ionized calcium in normal serum, ultrafiltrates, and whole blood determined by ion-exchange electrodes. J Clin Invest. 1970 Feb;49(2):318–334. [PMC free article] [PubMed]
  • Krishnamurthy M, Miotti AB. Von Willebrand's disease and pregnancy. Obstet Gynecol. 1977 Feb;49(2):244–247. [PubMed]
  • Reis E, Canterbury JM. A radioimmunoassay for parathyroid hormone in man. Proc Soc Exp Biol Med. 1968 Jun;128(2):501–504. [PubMed]
  • Reiss E, Canterbury JM, Egdahl RH. Experience with a radioimmunoassay of parathyroid hormone in human sera. Trans Assoc Am Physicians. 1968;81:104–115. [PubMed]
  • Reiss E, Canterbury JM. Application of radioimmunoassay to differentiation of adenoma and hyperplasia and to preoperative localization of hyperfunctioning parathyroid glands. N Engl J Med. 1969 Jun 19;280(25):1381–1385. [PubMed]
  • Berson SA, Yalow RS. Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma. Science. 1966 Nov 18;154(3751):907–909. [PubMed]
  • Sherwood LM, Mayer GP, Ramberg CF, Jr, Kronfeld DS, Aurbach GD, Potts JT., Jr Regulation of parathyroid hormone secretion: proportional control by calcium, lack of effect of phosphate. Endocrinology. 1968 Nov;83(5):1043–1051. [PubMed]
  • Reiss E, Canterbury JM, Bercovitz MA, Kaplan EL. The role of phosphate in the secretion of parathyroid hormone in man. J Clin Invest. 1970 Nov;49(11):2146–2149. [PMC free article] [PubMed]
  • DENT CE, HARPER CM, PHILPOT GR. The treatment of renal-glomerular osteodystrophy. Q J Med. 1961 Jan;30:1–31. [PubMed]
  • Avioli LV, Birge S, Lee SW, Slatopolsky E. The metabolic fate of vitamin D3-3H in chronic renal failure. J Clin Invest. 1968 Oct;47(10):2239–2252. [PMC free article] [PubMed]

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