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One of the challenges of High Performance Computing (HPC) in biology is resource accessibility.Computational Biology Applications Suite for High Performance Computing (BioHPC) is addressing this challenge at the user level as well as at the research group or administrator/developer level. BioHPC has been developed at the Computational Biology Service Unit (CBSU) of the Cornell University Life Sciences Core Laboratories Center (CLC) under the Microsoft HPC Institute program. This is an application suite that: (a) allows researchers from biological laboratories to submit their jobs to a parallel cluster through an easy-to-use web interface; (b) facilitates analysis of large data sets on a parallel platform; (c) allows biology research groups to set up Microsoft CCS and/or HPC 2008 based clusters for computational biology applications and allows efficient management via the BioHPC interface. The suite documentation and code are accessible at http://BioHPC.net. The suite can be downloaded and installed locally on any Microsoft based cluster.