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J Biomol Tech. 2010 September; 21(3 Suppl): S10.
PMCID: PMC2918091

Proteomics II: Applications

D. Friedman2
1University of Cambridge, Cambridge, United Kingdom;
2Vanderbilt University, Nashville, TN, United States

Abstract

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Each of the major proteomics technology platforms, notably those that focus on peptides (“bottom-up” or “shotgun” MS strategies) and those that focus on intact proteins (2D gel-based, MALDI-Imaging and ‘top-down‘ MS strategies) have unique strengths and limitations that in many cases can be complementary. The complementary nature of these approaches will be discussed in the context of the three presentations, which will highlight examples where multiple quantitative proteomics platforms are used to perform studies that address the same biological question.


Articles from Journal of Biomolecular Techniques : JBT are provided here courtesy of The Association of Biomolecular Resource Facilities