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An effective system for translating basic biomedical research into useful and effectively implemented clinical practices is essential to the nation's health. The Clinical and Translational Science Awards (CTSA) was initiated by NIH to transform the conduct of US biomedical research, speeding the translation of scientific discoveries into useful therapies. A national consortium enabling continuous exchange of ideas between and among NIH and CTSA institutions is a novel aspect of the program, which has contributed to link institutions in a robust network to share best practices and implement national, trans-CTSA initiatives. A number of targeted initiatives, involving several CTSA institutions, have been launched to develop specific network projects, including projects to develop a searchable national resource database to ensure that information and unique core resources are available and readily accessible across CTSA sites. Such efforts are facilitated by an integrated Biomedical Informatics network across CTSA institutions, and aim to eliminate geographic barriers for obtaining technologies and resources and avoid duplication of efforts across institutions. Access to such resources nationally will create powerful tools for acceleration of patient-oriented discovery that cannot be achieved with the resources of any individual site.