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A unique device has been introduced which isolates a mass spectrometer during nanospray LCMS/LCMSMS experiments from variable background ion interferences using purified room air. This device, an Active Background Ion Reduction Device (ABIRD), effectively reduces the omnipresent background ion signals typically observed (445 Da and related ion series) by an order of magnitude or more, depending on laboratory conditions. Many labs have reported an improvement in detection of low level peptides in complex mixtures with this device, as it enhances the signal to noise ratio across a broad mass range, allowing an ion trap instrument, for instance, to fill to target values with ions of interest rather than background ions. This device, available commercially only through ESI Source Solutions, Woburn, MA (http://www.esisourcesolutions.com), uses economical, long-lasting chemical filters, and has been adapted to a variety of instrument platforms.