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For this experts round table we assembled four experts from around the world who currently work in or direct proteomics core facilities. This will be a scientific session focusing on what methods, strategies and work flows that work best in a core facility environment and what should be avoided. We will discuss challenges and strategies for dealing with different types of projects including; biomarker analysis, quantitation, multidimensional separation and antibody pulldowns to name a few. We will also discuss current and emerging technologies and how they perform in the above environment.