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Located at Montana State University, the biomolecular Core Facilities support education and research by providing a wide range of multidisciplinary expertise, resources, and personnel. There are nine individual Cores, each focusing on a particular discipline: the Animal Resource Center, Bioinformatics, FACS, Functional Genomics, Imaging and Chemical Analysis (ICAL), Metabolomics, Microscopy, Proteomics, and TEM. The Bioinformatics Core provides training, manages computational clusters, organizes the Bioinformatics Users' Group, and provides support for genomic and proteomic analysis and computational tools. The Functional Genomics Core houses mini-fluorometers and nanodrop spectrometers; Affymetrix and slide array hybridization, scanning, and analysis equipment; and CombiMatrix arrays. Microdissection is provided via a Zeiss fluorescence-equipped microscope, PALM LMPC, and optical tweezers. The Microscopy Core provides optical and confocal microscopy with two Nikon microscopes for light and epi-fluorescent imaging and two Leica CSLMs. The confocal microscopes have multiple laser lines for excitation and a two-photon infrared laser for thicker samples. ICAL is dedicated to the characterization of materials through high resolution imaging and spectroscopy. Instrumentation includes AFM, FESEM, SEM, TOF-SIMS, X-ray powder diffraction spec, and scanning auger electron microprobe. The Metabolomics Core makes use of both NMR and MS to identify and quantify small molecule metabolites (<1000 Da) in complex biological systems, and the NMR facility is also involved in the characterization of protein structure and dynamics for larger molecules. MS and 2D-PAGE services are provided by the Proteomics Core for the analysis of proteomics, intact proteins, metabolites, and small molecules. Instruments include GCMS, MALDI with MS/MS, Agilent Chip Cube ion trap, and several high-resolution ESI-quad-TOFs. Cooperation between the Core Facilities improves efficiency and provides vertical integration for research: researchers can perform diverse experiments hands-on via open-access facilities, avoiding experiment outsourcing and the associated delays. This accelerates research and encourages researcher involvement in novel collaboratory projects.