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The Biomedical Genomics Core is a shared resource of The Research Institute at Nationwide Children's Hospital. We provide expertise in multiple aspects of genomics analysis, from assistance with appropriate experimental design to the final steps of bioinformatics and data interpretation. Services include consultation and assistance with experimental design, quality control of starting material (DNA or RNA), sample labeling, hybridization, image acquisition, data processing, statistical analysis and interpretation. Currently, investigators are able to choose from a wide array of commercially available catalog arrays from both Agilent Technologies and Affymetrix, or create low-cost custom arrays through Agilent's eArray technology. The diverse range of services provided by the core enables investigators to perform 1) Global transcriptional profiling of both mRNAs and microRNAs, 2) Gene regulation analysis to explore genome functions including mapping transcription factor binding sites and promoter region analysis (ChIP-on-Chip) and DNA methylation analysis, and 3) Whole genome analysis to conduct large-scale linkage analysis, association, and copy number studies. All array data generated by the core undergoes stringent quality control testing, and complete data analysis and statistical interpretation is performed in-house using advanced bioinformatics techniques. Strict sample submission requirements, including a minimum of four biological replicates for any given condition, combined with careful monitoring of sample quality prior to analysis, has significantly enhanced the generation of publication quality data sets. All users of the facility are encouraged to deposit their data into MIAME compliant public repositories, and assistance is provided with data submission into the NCBI Gene Expression Omnibus (GEO) database. The Biomedical Genomics Core has become nationally recognized and was recently awarded official “Certified Service Provider” status by Agilent Technologies, becoming the first and only academic laboratory in the United States to have achieved this status.