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The W. M. Keck Biomedical Mass Spectrometry Laboratory was established 14.5 years ago. Our expertise and advanced mass spectrometry instrumentation enable us to provide detailed characterization of proteins and proteomes for our researchers at a resonable cost. Equally important, we provide our researchers with consultations at both the experimental design and data analysis levels. The facility, through its large user-base and numerous professional contacts, serves as a focal point for the introduction of new techniques and technology to investigators. In the last year, we added a Thermo LTQ Velos Orbitrap Mass Spectrometer and a Thermo TSQ Quantum Access Max Triple Quadrupole MS as well as new services to meet the growing needs of our research community. These services include separation and characterization of proteins from a variety of biological sources; identification of post-translational modifications (phosphorylation, acetylation, ubiquitination, etc.); de novo (manual) sequence analysis of novel proteins; high resolution/mass accuracy measurements of peptides and small proteins; Binding partner analysis; and quantification of proteins using SRMs with heavy peptides or NSI-LC-MS-MS of chemically labeled peptides (TMT, iTRAQ, SILAC, or 18O).