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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
J Child Neurol. Author manuscript; available in PMC 2010 November 1.
Published in final edited form as:
PMCID: PMC2917804

Pediatric Low-Grade Gliomas


Pediatric low-grade gliomas encompass a heterogeneous set of tumors of different histologies. Cerebellar pilocytic astrocytomas occur most frequently followed by supratentorial diffuse fibrillary astrocytomas. Recent research has implicated activation of the RAS/RAF/MEK pathway in tumorigenesis of these tumors. Surgery is the mainstay of therapy. Overall survival rates for patients whose tumors are completely resected are 90% or greater, 10 years from diagnosis. Conversely, most optic pathway/hypothalamic, deep midline, and brain stem gliomas have minimal potential for resection; these tumors can be difficult to treat and deserve special attention. Combination chemotherapy is currently recommended as front-line adjuvant treatment for progressive or recurrent tumors. Second-line radiotherapy can also improve overall survival but is associated with more frequent and significant neurocognitive, endocrine, and other long-term toxicities.

Keywords: low-grade, glioma, astrocytoma, pilocytic, fibrillary

Pediatric low-grade gliomas are a heterogeneous set of tumors. They encompass tumors of astrocytic, oligodendroglial, and mixed glial-neuronal histology. Although their clinical behavior can vary, the majority of low-grade gliomas are indolent and do not undergo malignant transformation. Case reports have even described spontaneous regression of some tumors.1,2 This is in contrast to adult low-grade gliomas that have a more aggressive phenotype. One reason for the differences between the 2 populations may be the different frequencies of histological subtypes. Pilocytic astrocytomas infrequently occur in adults but are the leading histology in children. Conversely, diffuse gemistocytic astrocytomas, which have been associated with an increased tendency toward malignant progression, are rarely found in children.3 Low-grade gliomas are estimated to account for anywhere from 30% to 50% of central nervous system tumors in children.4-6

Discussion of gliomas can be confusing as it is a descriptive and not a pathological term. Tumors are classified according to the World Health Organization (WHO) criteria, most recently published in 2007, which describes their histological features and also provides a grading or “malignancy scale.”3 Low-grade gliomas encompass grade 1 and grade 2 tumors (Table 1).3 Grading is based on a number of factors including presence of necrosis, giant cells, mitosis, endothelial proliferation, hyperchromatic nuclei, and pleomorphic cells. These findings can be subjective, and retrospective studies have documented significant interpathologist disagreement on grading.7 Moreover, it can be difficult to distinguish a low-grade from a high-grade glioma.8

Table 1
Key Histological Features of Pediatric Low-Grade Gliomasa

Pediatric low-grade gliomas can be difficult to categorize as they can occur anywhere in the central nervous system and comprise multiple different tumor histologies. Historically, the cerebellum is the most prevalent location, and cerebellar low-grade gliomas account for 15% to 25% of all pediatric central nervous system tumors. They are followed by hemispheric (cerebral) gliomas (10%-15%), gliomas of the deep midline structures (10%-15%), optic pathway gliomas (5%), and brain stem gliomas (2%-4%; Figure 1).4 Children with neurofibromatosis type 1 account for the majority (over 70%) of the optic pathway/hypothalamic gliomas.9 In fact, 15% to 20% of children with neurofibromatosis type 1 will develop an optic pathway/hypothalamic glioma. Fortunately, only about half of them will become symptomatic and require treatment, usually before the age of 5.10-13 Low-grade brain stem gliomas include the dorsally exophytic, cervicomedullary, and focal brain stem gliomas and are to be distinguished from the more aggressive diffuse intrinsic brain stem gliomas.

Figure 1
Distribution by location of pediatric low-grade gliomas. Shown are the approximate frequencies of low-grade gliomas compared with all pediatric central nervous system tumors.

The 2 most common low-grade glioma histologies in children are the pilocytic (WHO grade 1) and diffuse fibrillary astrocytoma (WHO grade 2). The former occurs mainly in children aged 5 to 19 years with a peak incidence in the 5- to 9-year-old age range.14 The age distribution for diffuse fibrillary astrocytomas is older, with only 10% occurring below the age of 20 years.15 Pilocytic astrocytomas can arise anywhere in the central nervous system; however, they predominate in the cerebellum,16-18 optic pathway,19,20 and dorsally exophytic brain stem.21 Conversely, diffuse fibrillary astrocytomas are more frequent in the supratentorial region, deep midline structures, and the cervicomedullary region.3,22

Other, less common, low-grade glioma histologies in children include pilomyxoid astrocytoma, pleomorphic xanthoastrocytoma, ganglioglioma, subependymal giant cell astrocytoma, and oligodendroglioma. The term “pilomyxoid” astrocytoma was first introduced in 1999 to describe a subset of pilocytic tumors with more aggressive clinical behavior and has since been included in the most recent World Health Organization classification of central nervous system tumors.23 Pilomyxoid astrocytomas (WHO grade 2) tend to occur in very young children (mean age 18 months) and localize in the hypothalamic region.24 Pleomorphic xanthoastrocytomas (WHO grade 2) have a propensity for the supratentorial region, most often the temporal lobe, but their age distribution and clinical phenotype are more similar to pilocytic astrocytoma. Gangliogliomas (WHO grade 2) localize in the temporal lobes and have a mean age at diagnosis of 9.5 years.25 Intraventricular subependymal giant cell astrocytomas (WHO grade 1) occur almost exclusively in children with tuberous sclerosis syndrome. Oligodendrogliomas (WHO grade 2) account for only 2% of brain tumors in children <14 years of age; the most common site of occurrence is the frontal lobe. This review will focus on pilocytic astrocytoma and diffuse fibrillary astrocytoma, as they account for the majority of pediatric low-grade gliomas and approximately one quarter of all primary central nervous system tumors in children.15

Clinical Presentation

The clinical presentation for children with low-grade gliomas, regardless of histology, can be grouped into generalizing and localizing symptoms. Almost 50% of children will have had 6 months or longer symptom duration prior to the eventual diagnosis.26 Generalizing symptoms are due to increased intracranial pressure from obstruction of the ventricles and include headaches (particularly in the morning), nausea, vomiting, and lethargy. Physical examination findings include decreased upward gaze, sixth cranial nerve palsies, and papilledema. These are most often caused by tumors located in the cerebellum, optic chiasm/hypothalamus, dorsally exophytic brain stem (which arise from the floor of the fourth ventricle and grow into the ventricle), and tectum (which obstruct the cerebral aqueduct).

Localizing symptoms are dictated by tumor location and include focal neurological findings, seizures and endocrinopathies. In particular, cerebellar tumors are associated with ataxia and dysmetria. The presentation of tumors of the cerebral hemisphere depends upon which lobe is involved and includes seizures, hemiparesis, and behavioral changes. Children with tumors of the hypothalamus and/or pituitary gland can suffer from obesity, failure to thrive, diabetes insipidus, other endocrine dysfunction, and visual field deficits from compression of the optic chiasm. Optic pathway gliomas may arise anywhere along the visual pathway (Figure 2). Children with sporadic optic pathway gliomas are more likely to present with chiasmal and postchiasmal involvement, whereas multifocal and bilateral optic nerve involvement is seen almost exclusively in children with neurofibromatosis type 1.10,27 Children can present with decreased visual acuity, optic nerve atrophy, proptosis, or strabismus. Low-grade gliomas of the brain stem are indolent by nature and often have a long clinical course (months to years) before diagnosis. Although they do not significantly infiltrate the brain stem, both the dorsally exophytic and cervicomedullary tumors can cause lower cranial nerve deficits (dysphagia, dysarthria, abnormal breathing) and long tract signs (hemiparesis, spasticity, hyperreflexia, Babinski's sign). The cervicomedullary gliomas also present with torticollis, long tract signs, and sensory loss from involvement of the upper cervical cord. Focal brain stem tumors are predominantly tectal in location and therefore present principally with hydrocephalus, although cranial nerve deficits, hemiparesis, and Parinaud syndrome are rarely seen.

Figure 2
Postgadolinium magnetic resonance (MR) images of (A) optic nerve glioma (axial), (B) optic chiasm/hypothalamic glioma (coronal), and (C) optic tract/radiation tumor (axial).


Pediatric low-grade gliomas share similar characteristics on neuroimaging. On magnetic resonance imaging (MRI), they tend to be hypointense on T1-weighted, hyperintense on T2-weighted, and have varying degrees of enhancement on postgadolinium sequences. Pilocytic astrocytomas usually appear as well-circumscribed tumors, often with a large cystic component and an enhancing mural nodule (Figure 3). Diffuse fibrillary astrocytomas are less circumscribed and typically do not enhance to a large extent (Figure 4).

Figure 3
Sagittal postgadolinium magnetic resonance image of a pilocytic astrocytoma of the cerebellum.
Figure 4
Axial magnetic resonance images of a right thalamic fibrillary astrocytoma status postbiopsy. A, Heterogeneous and hyperintense on T2-weighted images. B, Minimal enhancement on postgadolinium imaging. The patient had left hemiparesis. Because of its location, ...

Surgical biopsy, and total tumor resection when feasible, is recommended to verify tumor histology. To preserve optic nerve function, many children with optic pathway/hypothalamic gliomas do not undergo diagnostic biopsy if the MRI characteristics are consistent with low-grade glioma, especially if there is a prior diagnosis of neurofibromatosis type 1. Biopsies of deep midline and brain stem tumors are also to be pursued cautiously, especially if they are asymptomatic and have not progressed on serial MRI evaluations.

Staging for the majority of tumors includes postoperative MRI of the tumor resection site to determine extent of resection. This should be performed within 24 to 48 hours after surgery to best distinguish residual tumor versus postoperative changes. Dissemination and leptomeningeal involvement are uncommon; however, if suspected, MRI of the entire spine and cerebrospinal fluid sampling for cytology should also be considered.18


The tumorigenesis of pediatric low-grade gliomas is not well understood. One of the limiting factors has been failure to identify common molecular abnormalities in tumor specimens. Traditional karyotype analysis has been unrevealing in multiple studies, with chromosome 7 gain the only consistent finding, but present in a minority of tumors.28-32 Conventional genomic hybridization and the first generation of single nucleotide polymorphism arrays also failed to identify consistent molecular abnormalities.33,34 More recently, multiple groups have reported a small nonrandom duplication in the 7q34 region in the majority of pilocytic astrocytomas, identified using high-resolution single nucleotide polymorphism arrays.35-39 The 7q34 duplication involves a known oncogene, BRAF, and appears to result in upregulation of the RAS/RAF/MEK pathway (Figure 5). Studies looking at adult tumors have also shown that the RAS/RAF/MEK pathway is activated in gliomas.40 Other biological mechanisms under investigation in low-grade gliomas include angiogenesis and the tumor microenvironment, telomere maintenance, and glioma-associated antigens.41-43

Figure 5
Pediatric low-grade glioma tumorigenesis. BRAF, an oncogene implicated in malignant melanoma and other carcinomas, may be involved in the tumorigenesis of sporadic low-grade gliomas. A BRAF fusion gene with increased kinase activity upregulates the downstream ...

Pediatric low-grade gliomas do not harbor the same molecular abnormalities as their adult counterparts. For example, adult low-grade gliomas show frequent TP53 mutations, present in up to 88% of gemistocytic and 53% of diffuse fibrillary astrocytomas. TP53 mutations in children appear to be restricted to 5% to 10% of low-grade gliomas that undergo malignant transformation.44,45 Loss of heterozygosity of chromosomes 1p36 and 19q13, and in particular codeletion at both loci, is a favorable prognostic factor in adults with oligodendrogliomas (WHO grade 2) but has not been replicated in pediatric tumors.46

Tumors in children with genetic susceptibility syndromes such as neurofibromatosis type 1 and tuberous sclerosis syndrome provide some insight into the signal transduction pathways involved in development of low-grade gliomas. The neurofibromatosis type 1 model shows that inactivation of the tumor suppressor neurofibromin results in upregulation of the RAS family of proteins, involved in a number of oncogenic signal transduction pathways in astrocytes.47 Attempts to modulate this upregulation by the use of farnesyl transfererase inhibitors have been largely unsuccessful. Mutations in 1 of 2 tumor suppressor genes, TSC1 and TSC2, result in tuberous sclerosis syndrome. These 2 genes form an intracellular complex (called the tuberous sclerosis complex) that is also involved in the RAS pathway and contains a guanosine triphosphatase–activating property for a small G protein, Ras homologue enriched in brain. This homologue can directly activate mammalian target of rapamycin.48 Interestingly, neurofibromatosis type 1 tumors have also been shown to have increased mammalian target of rapamycin expression, albeit by a different mechanism (Figure 5).49 Inhibitors of mammalian target of rapamycin, such as rapamycin, are effective in causing regression of subependymal giant cell astrocytomas in patients with tuberous sclerosis syndrome50 and trials are currently being considered for refractory low-grade gliomas in patients with neurofibromatosis type 1.

Treatment and Outcomes

Surgery remains the mainstay of therapy for pediatric low-grade gliomas, and gross total resection is the most consistent prognostic factor for prolonged progression-free and overall survival.26,51-55 As such, treatment decisions for children with low-grade gliomas can be stratified into 3 main groups as follows: (1) children with tumors that have been fully resected, (2) children with tumors that have undergone subtotal resection, and (3) children with tumors that have undergone biopsy only or no surgical approach is feasible. The latter group deserves special attention and usually involves tumors in the deep midline supratentorial region, optic pathway/hypothalamus, and brain stem.

Low-grade gliomas in the cerebellum and superficial cerebrum are most amenable to resection. Children in whom a gross total resection has been achieved, confirmed by surgeon's report and/or postoperative brain MRI within 24 to 48 hours of surgery, often do not need any further therapy. In several series, complete resection was associated with 10-year overall survival rates of 90% or greater and rare tumor recurrences.18,26,51,53,56,57 Therefore, postoperative management is directed toward close clinical and radiographic follow-up, especially if the tumor histology has concerning features. Reports are conflicting because of the difficulty distinguishing the prognostic effect of histology from that of extent of resection, but tumor histology does appear to be an independent predictor of progression. Nonpilocytic, and specifically diffuse fibrillary, histology is more highly associated with progression, recurrence, and anaplastic transformation, although the latter is rare in children.8,26,51,54,55 Children have better survival than adults,58-61 but the role of age as a prognostic factor within children is unclear.18,55,62-64

The treatment decision for children with subtotal resection has been controversial. If the likelihood of functional impairment is minimal and the neurosurgeon thinks it is feasible, a repeat surgery can be attempted to remove the residual tumor.65,66 Others advocate a “wait and see approach” with follow-up brain MRI at 3- to 6-month intervals.67-69 Because the tumors tend to be indolent by nature, the decision for a repeat resection or adjuvant treatment can be postponed until there is either measurable progression by neuroimaging or clinical symptoms. This interval may last several years and some tumors may never progress. In 1 series looking at 128 children with subtotal resection of low-grade gliomas, 58% had no evidence of tumor progression 7 years from diagnosis.57 A prospective intergroup study between Children's Cancer Group and Pediatric Oncology Group (prior to the creation of the Children's Oncology Group) of 660 children reported a 5-year progression-free survival of 45% to 65% for residual tumor of any size.68 In addition, the value of postoperative adjuvant radiotherapy for residual low-grade glioma is unclear. Although it may improve progression-free survival,51,52,70 studies suggest this does not necessarily translate into improved overall survival, especially in children.51,57,58 Other studies show no advantage in progression-free survival with immediate irradiation.26,57 Thus, adjuvant therapy should be reserved for when tumors progress and re-resection is not feasible. The role of radiotherapy and chemotherapy in this setting will be discussed below.

Low-grade gliomas in the supratentorial midline areas are often not amenable to initial resection (Figure 4). For this cohort of children, observation until radiographic progression has been an accepted approach if there are minimal clinical symptoms. When progression occurs, adjuvant therapy should be considered. Historically, focal radiotherapy was used in this setting with standard doses of 45 to 54 Gy.71-75 Although the data looking at the impact of radiotherapy on overall survival are conflicting, retrospective studies combining adults and children reveal improved survival associated with administration of conventional radiotherapy.59,76,77 Other studies focused on children reveal the value of radiotherapy, particularly for optic pathway/hypothalamic gliomas (10-year progression-free survival of 65%-90%).73,74,78,79 In addition, it appears that almost half of irradiated low-grade gliomas in children have at least a 25% reduction in tumor size.79,80 Despite these potential benefits, the risks of radiotherapy to the developing nervous system have been well documented.81-86 Radiotherapy of low-grade gliomas of the cerebral hemisphere is associated with both hormone deficits and cognitive impairment.51,87,88 Treatment of optic pathway/hypothalamic gliomas can result in endocrine dysfunction,73,74,89 cerebrovascular disease,90,91 secondary malignant neoplasms,92 and neurocognitive deficits,20,79,93 particularly in young children.

To defer radiotherapy and its adverse effects, especially in infants and young children, chemotherapy is now the front-line adjuvant therapy for children with progressive low-grade gliomas. The combination of carboplatin and vincristine has been shown to result in tumor reduction or stable disease and a 3-year PFS of 68%.94 Unfortunately, up to 40% of children experience hypersensitivity reactions with carboplatin, more common with increased number and frequency of doses.95,96 An alternative regimen of 6-thioguanine, procarbazine, lomustine (CCNU), dibromodulcitol, and vincristine has also been shown to be effective, with a 3-year PFS of 45%.97 Because of side effects and drug availability, dibromodulcitol was not included in a randomized Children's Oncology Group protocol comparing thioguanine/procarbazine/CCNU/vincristine (TPCV), with the combination of carboplatin and vincristine. Preliminary results of this study show a trend for improved event-free survival for the TPCV regimen, but this is not significant.98

Initial management of optic pathway/hypothalamic gliomas is usually observation with serial MRI scans and ophthalmologic examinations.27,99 Most tumors remain indolent, and when they progress, it is often slow in pace.100,101 A concurrent diagnosis of neurofibromatosis type 1 appears to be associated with a favorable progression-free survival and lower likelihood of visual morbidity.10,63,102-104 Location is also important; tumors in the anterior visual pathway (optic nerves and chiasm) have a better visual outcome than tumors involving the hypothalamus and optic tracts/radiations.105,106 Treatment is reserved for patients with a documented decline in visual acuity or significant tumor progression on MRI scan with associated symptoms and signs. Rarely, treatment is advocated at diagnosis for patients with severe visual impairment, extensive tumor, and/or involvement of the posterior visual pathway. Surgical resection is rarely pursued because of the risk of further visual decline as well as the endocrinologic and cerebrovascular risks. Exceptions include unilateral optic nerve tumors with absent or severe impairment of vision and painful or disfiguring proptosis. Tumor debulking is sometimes undertaken for large chiasmal/hypothalamic tumors that cause hydrocephalus via obstruction of the third ventricle or exert mass effect on surrounding structures. Although radiotherapy for optic pathway/hypothalamic glioma is associated with excellent, long-term, progression-free survival, its use is rarely advocated because of the profound risk of unacceptable morbidity (as described above), particularly in patients with neurofibromatosis type 1. Therefore, chemotherapy, specifically carboplatin with vincristine, has become the mainstay of initial therapy for optic pathway/hypothalamic gliomas.27 To date, this regimen is associated with the best progression-free survival, especially in patients with neurofibromatosis type 1, and allows radiotherapy to be deferred until patients are older.94,107 Other regimens, such as TPCV, are avoided in patients with neurofibromatosis type 1 because of their underlying leukemia predisposition108-111 and the risk of secondary leukemia associated with lomustine and procarbazine.112-114

Brain stem gliomas also constitute a unique category of low-grade gliomas, and specific location provides guidance for treatment. The primary treatment for dorsally exophytic brain stem gliomas is surgical (Figure 6A). However, aggressive surgery to achieve a gross total resection is not advocated, due to the risks associated with this approach and because the majority of patients remain progression free after near total resection.21,115 Tumors that recur can be controlled with repeat resection and/or radiotherapy. Chemotherapy is primarily used to delay radiotherapy in young patients. Cervicomedullary gliomas tend to grow slowly and are often managed conservatively with close observation for an extended period of time (Figure 6B). Evidence of radiographic or clinical progression should prompt referral to neurosurgery. Gross total resections are possible, but more often the tumor cannot be removed completely without unacceptable risk. For tumors that progress following surgery, adjuvant therapy is recommended. Five-year progression-free survival after initial surgical management exceeds 60%.22,116 Tectal gliomas also tend to be indolent and rarely cause functional impairment (Figure 6C). Progression occurs in 15% to 25% of tumors.117 Therefore, management is directed toward resolution of the hydrocephalus via shunting or endoscopic third ventriculostomy. Patients are then observed and biopsy and adjuvant therapy reserved for patients with radiographic and clinical progression.117-120

Figure 6
Magnetic resonance (MR) images of low-grade gliomas of the brain stem. A, Postgadolinium sagittal image of a dorsally exophytic glioma. B, Postgadolinium sagittal image of a cervicomedullary glioma. C, T2-weighted sagittal image of a tectal glioma.

Future Directions

Despite the excellent overall survival for these patients, the management of pediatric low-grade gliomas remains a challenge. Because a number of these tumors will be indolent, the treatment must not be worse than the disease. The focus of therapy is to provide long-term survival with as few potential long-term sequelae as possible. Fortunately, complete resection is able to provide cure for many children. When this is not possible, front-line chemotherapy regimens, such as the combinations of carboplatin and vincristine, or TPCV can result in stable disease or even tumor regression for an extended period of time. Unfortunately, there are few, proven, effective, second-line chemotherapy regimens for refractory or recurrent low-grade gliomas. Cisplatin plus etoposide has been evaluated in a small group of children with unresectable low-grade gliomas with a reported 3-year progression-free survival of 78%;121 however, this approach should be taken cautiously given the risk of moderate-to-severe hearing loss and secondary leukemia with these agents.122-124 Weekly vinblastine is promising with initial studies indicating stable disease in the majority of children who were switched to it because of carboplatin sensitivity125 or recurrent/refractory disease.126 Temozolomide as a single agent has shown to be active in pediatric low-grade gliomas127-129 and is currently being explored in combination with other agents. More recently, the combination of bevacuzimab and irinotecan, a regimen used to treat high-grade gliomas, has been shown to result in objective durable responses.130 Additionally, as we learn more about the signal transduction pathways that lead to pediatric low-grade glioma tumorigenesis, molecularly targeted drugs may also be developed as therapeutic options.

Radiotherapy should also be considered for refractory or recurrent tumors, especially in older children. In considering the use of this modality, careful consideration of the long-term morbidity of radiotherapy, particularly the potential neurocognitive effects, must be weighed. Multiple studies confirm the adverse impact of whole brain irradiation on intelligence quotient (IQ) in survivors of pediatric brain tumors.86,131,132 Focal radiotherapy to tumors of the cerebral hemispheres and optic pathway can also affect IQ79,85,93 and is associated with the child's need for special education.20,51 Other neurocognitive effects of radiotherapy to the brain include memory impairment and attention problems, and these effects are not limited to young children.133-135

Newer approaches to minimize the long-term morbidity of radiotherapy are being evaluated. Conformal radiotherapy with a tighter margin around the tumor achieved a 2-year actuarial event-free survival of 88% in 38 children with low-grade astrocytoma.136 More sophisticated techniques, such as intensity-modulated, proton andstereotactic radiotherapy, have been developed that enable delivery of targeted therapy to the tumor while limiting exposure to surrounding normal brain tissue.137-140 One large study of 50 children with low-grade gliomas treated with stereotactic radiotherapy reported a 5-year progression-free survival of 82.5%.140 Although the short-term progression-free survival for this and other studies appear equivalent to conventional radiotherapy,137-140 the long-term toxicity, particularly neurocognitive, has yet to be carefully evaluated.

Despite these advances in therapy, it is becoming increasingly recognized that a number of pediatric long-term survivors have significant adverse outcomes that are not always associated with radiotherapy. Cerebral hemisphere location, younger age at diagnosis, and hydrocephalus requiring a shunt have all been found to be significant predictors of lower cognitive performance on IQ scales.135 Children with infratentorial tumors can have significant language, cognitive, behavioral, and social dysfunctions.141-144 A combined analysis of Children's Cancer Group (CCG-9891) and Pediatric Oncology Group (POG-9130) data of 103 children with low-grade cerebellar astrocytomas treated with surgery alone revealed an elevated risk of cognitive and adaptive-behavioral impairment that was not associated with complications of the tumor or surgery.145 Similar deficits were found in 93 children with extracerebellar tumors treated with surgery alone.146

Therefore, even in the absence of radiotherapy, parents of children with low-grade gliomas must be properly counseled not only on the risk of tumor progression or recurrence but also the risk of neurocognitive and behavioral impairments. Physicians caring for children with low-grade glioma should consider early referral to neuropsychologists for baseline evaluations that may identify potential deficits in learning and processing, so that appropriate interventions can be put in place. Outcomes research needs to focus not just on the effects of radiotherapy and IQ but more on specific cognitive domains associated with the regions of brain affected by the tumor and treatments. In addition, a better understanding of the adaptive, social, and behavioral outcomes of survivors of pediatric low-grade glioma is essential.


The authors would like to thank Jane E. Minturn, MD, PhD, for her help with figure design.


The authors have no conflicts of interest to disclose with regard to this article.

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