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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
Am J Geriatr Cardiol. Author manuscript; available in PMC 2010 August 3.
Published in final edited form as:
Am J Geriatr Cardiol. 2007 Mar–Apr; 16(2): 76–83.
PMCID: PMC2914576
NIHMSID: NIHMS215989

Depression and Nursing Home Admission Among Hospitalized Older Adults with Coronary Artery Disease: A Propensity Score Analysis

Ali Ahmed, MD, M.P.H., FACC, FSGC,1,2,3,4 Christina M Lefante, M.P.H.,5 and Nazmul Alam, M.P.H.2

Abstract

Admission to nursing home (NH) is considered a poor outcome for community-dwelling older adults. The objective of this study was to determine if depression increased risk of NH admission. Using the 2001–2003 National Hospital Discharge Survey datasets, the authors identified 28,172 community-dwelling older adults, 65 years and older, discharged alive with a primary discharge diagnosis of coronary artery disease. The objective of this study was to determine association between depression and subsequent nursing home admissions in these patients. Propensity scores for depression, calculated for each patient using multivariable logistic regression model, were used to match 686 depressed patients with 2,058 non-depressed patients who had similar propensity scores. Logistic regression analyses were used to determine the association between depression and NH admission. Patients had a mean (±SD) age of 77 (±8) years and 61% were women. Compared with 9% non-depressed patients, 13% of depressed patients were admitted to nursing homes (relative risk =1.42; 95% confidence interval =1.12–1.78). When adjusted for various demographic, clinical, and care-related covariates, the association became somewhat stronger (adjusted relative risk =1.55; 95% confidence interval =1.21–1.99). In ambulatory older adults hospitalized with CAD, a secondary diagnosis of depression was associated with a significant increased risk of NH admission.

Coronary artery disease (CAD) is common, and the prevalence and incidence increase with age. Older adults suffer disproportionately from CAD, with over 80% CAD-related deaths occurring in patients 65 years and older.1 Depression is also common among older adults, and is associated with poor outcomes.2 Depression is particularly common among patients with CAD, and is associated with poor outcomes in these patients.3-9

Admission to a nursing home (NH) is often considered a poor outcome for community-dwelling older adults, which is associated with loss independent living, poor quality of care and poor prognosis.10, 11, 12 Hospitalization due to chronic disease or its acute exacerbation is also considered an adverse outcome, and is associated with increased risk of NH admission for community-dwelling older adults.13-15 However, it is unknown to what extent depression is associated with subsequent NH admission for ambulatory older adults hospitalized with CAD. The objective of the current study was to determine the effect of depression on NH admission in older adults hospitalized for CAD.

METHODS

Data Source

The National Hospital Discharge Survey (NHDS) consists of a continuous sample of hospital discharge records abstracted annually from medical records of patients treated at nonfederal short-stay hospitals in all fifty states and the District of Columbia.16 The NHDS datasets are available to the public through the Centers for Disease Control and Prevention website at http://www.cdc.gov/nchs/about/major/hdasd/nhds.htm. Inclusion eligibility is restricted to hospitals having six or more beds and where the average length of stay for all patients is less than thirty days. The sample is updated periodically to reflect changes in eligibility. Medical diagnoses and surgical procedures contained in the NHDS are coded according to the International Classification of Disease, 9th revision, Clinical modification (ICD -9-CM) codes. The NHDS adopts a complex, stratified, multistage probability design to ensure a representative national sampling. Variables in the NHDS dataset include data on age, gender, race, marital status, primary discharge diagnosis and six secondary discharge diagnoses, hospital bed size, hospital geographic location, hospital ownership, type of hospital admission, primary and secondary source of payment, discharge month and length of stay.17

Patients

For the purpose of this analysis, we merged the 2001, 2002 and 2003 NHDS datasets, and restricted our analysis to patients with a primary discharge diagnosis of CAD. The 2001 – 2003 NHDS datasets included 976,995 sampled hospital discharges. Patients younger than 65 years, those with pre-admission residence in NH, and those who died during their hospital stay were excluded (Figure 1).

Figure 1
Selection of the study cohort

Primary Diagnosis of Coronary Artery Disease

Patients with a primary discharge diagnosis of CAD were identified by the ICD-9-CM codes 410, 411, 412, 413 and 414. Of the 976,995 patients in the 2001 -2003 NHDS datasets, 30,010 were aged ≥65 years and discharged with a primary discharge diagnosis of CAD (Figure 1). Of these, 28,172 were discharged alive from the hospital. It is important to note that the NHDS is based on coded hospital discharge records and collected information does not allow identification of individual patients. There is a possibility that patients with multiple hospitalizations were captured more than once but these duplications are likely to be random. As such, we treated each discharge as representing a unique patient in our analyses.

Secondary Diagnosis of Depression

Out of the 28,172 individuals with CAD, a total of 686 patients were identified as having a secondary diagnosis of depression at time of discharge. These individuals were identified using ICD-9-CM codes 296 (affective psychoses, includes 296.0 – 296.9), 311 (depressive disorder, not elsewhere classified), and 300.4 (neurotic depression).

Primary Outcome

The primary outcome of interest was NH admission as ascertained at the time of hospital discharge, and identified from the “discharge status” variable in the datasets.

Other Secondary Diagnoses

The NHDS collected data on up to six secondary discharge diagnoses for each patient. Using this record, a list of co-morbid conditions based on ICD-9 codes was assembled. The list included heart failure (428), dysrhythmias (427), hypertension (401-405), diabetes mellitus (250), hypothyroidism (244), chronic obstructive pulmonary disease (491-492, 496), pneumonia (480-487), syncope (780.2), acute renal failure (584), iron deficiency anemia (280), urinary incontinence (788), urinary tract infection (599), and dementia (094, 290, 291, 292, 294 and 331). These other secondary diagnoses were chosen due to their known associations with either the predictor variable, a secondary diagnosis of depression, or the outcome variable, admission to a NH.

Statistical Analysis

After descriptive analysis of the baseline characteristics for the pre-match cohort of patients with and without depression (Table 1, left hand panel), propensity scores were calculated to control for the imbalance in baseline covariates between patients. Matching by propensity score often balances all measured covariates and is superior to matching by individual covariates such as age, sex, race, etc. The propensity score is the conditional probability of receiving a particular exposure or treatment given a vector of covariates,18-20 and has been used in the literature to control for selection bias between two treatment groups.21-23 More recently, the technique has been used to control for the imbalance in baseline covariates between two groups of patients with and without a certain co-morbid condition.24 One of the key limitations of propensity score technique is, however, that unlike randomization, it cannot balance unmeasured covariates. However, as patients cannot be randomized to develop depression, that is less of a concern for the current analysis.

Table 1
Baseline patients characteristics by the depression pre and post-matched with propensity scores

We calculated propensity scores for depression, using a non-parsimonious multivariable logistic regression model, with depression as the dependent variable, and all measured baseline characteristics as covariates. The covariates used in the model are presented in Table 1. The resulting propensity score for depression was used to match patients who had a secondary diagnosis of depression with up to three patients without the secondary diagnosis who had similar propensity scores. An SPSS macro was used to randomly match patients.25 Overall, 686 patients with depression were matched with 2058 patients without depression.

Baseline characteristics between the patients with and without depression in post-match cohort were compared, and absolute standardized differences on key covariates were estimated.26, 27 Bivariate and multivariable logistic regression analyses were conducted to assess NH admission for depressed patients compared with those not depressed. Covariates in the multivariable model were the same as those used in the model for propensity score. The effect of other covariates on NH admission was also examined using the same model, with age and length of stay as categorical variables. Odds ratios and their 95% confidence intervals were then converted into relative risks.28 The effects of depression on subgroups of patients based on age, sex, race, marital status, heart failure, diabetes, dementia, and hypothyroidism were examined. All tests were based on a 2-sided p value and p values of <0.05 were considered significant. All analyses were done using SPSS 13.2 for Windows.29

RESULTS

Patient Characteristics

After propensity score matching, the final cohort (N=2,744) had a mean (±SD) age of 77 (±8) years, 1,668 (61%) were female, and 119 (4%) were reported as African Americans. Table 1 compares the baseline characteristics between patients with and without a secondary diagnosis of depression, before and after propensity score matching. Before matching, depressed patients were more likely to be female and have hypothyroidism, dementia and incontinence. Depressed patients were also less likely to be African Americans and have UTI, cardiac dysrhythmias, pneumonia, and acute renal failure. After matching, there was no significant difference in terms of any baseline covariates between the two groups (Table 1).

Depression and Nursing Home Admission

Compared with 9% of ambulatory older adults hospitalized with CAD who also had no secondary diagnosis of depression, 13% of those with a secondary diagnosis of depression were admitted to NH (relative risk = 1.42; 95% confidence interval = 1.12 – 1.78) (Table 2). When adjusted for various demographic, clinical, and care-related covariates, the association became stronger (adjusted relative risk = 1.55; 95% confidence interval = 1.21 – 1.99). Additional adjustment for propensity score did not alter this association (Table 2).

Table 2
Unadjusted and adjusted odds ratios (OR), relative risk (RR) and 95% confidence intervals (CI) for admission into nursing home among propensity score matched older adults discharged with a primary discharge diagnosis of coronary artery disease by depression ...

Other Predictors of Nursing Home Admission

Nursing home admission was greater among individuals aged 80 and older, while less likely among married individuals (Table 3). A secondary diagnosis of heart failure, urinary tract infection, urinary incontinence, and dementia as well as a length of hospital stay 4 or more days were associated with higher odds of NH admission. Patients who were hospitalized in the South and admitted to hospitals with bed size 500 or more had lower odds of being discharged to a NH.

Table 3
Association between the covariates with admission into long-term care facilities

Results of the Subgroup Analysis

The association between depression and NH admission was observed in almost all subgroups of patients (Figure 3). Patients with a secondary diagnosis of dementia had the highest rate of admission to NH after hospital discharge: 35% and 26% respectively for patients with and without a secondary diagnosis of depression. There was no significant interaction observed between NH admission and included covariates.

DISCUSSION

Our study found that in a wide spectrum of ambulatory older adults hospitalized with CAD, the presence of a secondary diagnosis of depression or heart failure was significantly associated with NH admission. We also noted that traditional risk factors such as older age, unmarried marital status, presence of a secondary diagnosis of dementia, or urinary incontinence, were also associated with NH admission in these patients. These findings are important as NH admission is a marker of loss of independent community living and poor prognosis, and depression is common, and an identifiable and treatable condition.

Possible mechanistic explanations

Little is known about the specific physiologic mechanisms through which depression adversely affects hospital discharge disposition for these individuals. Increased depression-associated mortality in patients with CAD has been linked to increased platelet aggregation, greater autonomic dysfunction, immunological and hematological abnormalities, and behavioral and life style factors such as poor self-care and non-compliance.30-34 It is possible that CAD patients who are also depressed were sicker and had more severe CAD and thus poor outcomes such as NH admission. This is supported by our observation that CAD patients who also had a secondary diagnosis of heart failure were at increased risk of NH admission. However, as can be seen from Table 1, there was no significant difference in the proportion of patients with or without depression who also had heart failure as a secondary diagnosis. Therefore, it is unlikely that the effect of depression on NH admission observed in our study was mediated by heart failure. It is also possible that depressed CAD patients were more functionally impaired than those without depression. However, we had data on major disease conditions that are markers for functional impairment in old age, such as dementia and heart failure, and there were no baseline imbalance in those between groups. It is also possible that depressed patients lost physical function at a faster rate, or were unable to recover from the functional loss in due course, and thus were more likely to be admitted to NH.

Comparison with relevant findings from the literature

Most studies involving depression and CAD involve relatively younger adults.3, 5, 7 and none of these studies examined the effect of depression on NH admission. Our study is the first to demonstrate that the adverse effects of depression in patients with CAD also include loss of independent living in the community via admission to a NH. We noted that in addition to traditional predictors of NH admission, a secondary diagnosis of heart failure was also associated with a higher risk. This is an interesting observation and requires further study of the possible link between heart failure, CAD, and NH admission. It is not clear as to why patients hospitalized in the South and in large hospitals were less likely to be admitted to NH.

Strengths and limitations

Our study has several strengths. It is based on a nationally representative sample of older adults hospitalized with CAD. Our use of propensity score matching allowed us to achieve a reasonable balance in baseline covariates between patients with and without depression. Exclusion of patients with NH residency prior to hospitalization allowed us to examine the effect of depression on NH admission among patients who were community-dwelling prior to hospital admission. Current NH residency is a strong predictor of NH re-admission after hospital discharge.15, 35, 36 Finally, we expressed our results in risk ratio, as opposed to odds ratio, thereby avoiding possible inflation of the association and making it easier to interpret.28, 37

Limitations of our study include use of secondary diagnosis of depression which is often coded for billing purposes. Depression in older adults is often atypical, presenting with somatic symptoms, and difficult to diagnose.38 It is possible that assessment of depression was not a priority in an acute care setting, which in part explains the lower prevalence of depression (Table 1) observed in our study compared to other studies.39 It is possible that those listed as having a secondary diagnosis of depression were individuals with severe depression, or those with anti-depressant medication listed as a discharge medication. It is also reasonably possible that many depressed patients were classified as not having a secondary diagnosis of depression, and some non-depressed patients were classified as having depression. This misclassification was most likely independent of the occurrence of the outcome (NH admission) and therefore random. Random misclassification increases the similarity between the two groups, thus resulting in dilution or underestimation of the true relative risk or odds ratio.40 Finally, limited ability to adjust for comorbid conditions and their severity in administrative datasets and the inability of propensity scores technique to adjust for unmeasured covariates must be acknowledged.

Conclusions

A secondary diagnosis of depression was associated with increased risk of admission to NH among ambulatory older adults hospitalized with CAD. Future prospective cohort studies should be conducted to examine the effect of depression on NH admission and other outcomes important to older adults such as physical function and quality of life, and if therapy with anti-depressants would reduce these adverse effects.

Figure 2
Effect of depression on nursing home admission among community dwelling older adults hospitalized with coronary artery diseases (CAD)

Acknowledgments

Dr. Ahmed is supported by the National Institutes of Health through grants from the National Institute on Aging (1-K23-AG19211-04) and the National Heart, Lung, and Blood Institute (1-R01-HL085561-01 and P50-HL077100).

Footnotes

Author Contributions

AA conceived the study hypothesis and design, and wrote the paper in collaboration with CML and NA. CML and NA performed the statistical analysis under supervision of AA. All authors analyzed and interpreted the data, participated in critical revision of the paper for important intellectual content, and approved the final version of the article. All had full access to the data.

Location of work: University of Alabama at Birmingham, Birmingham, Alabama, USA

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