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Arthritis Res Ther. 2010; 12(3): 125.
Published online 2010 June 18. doi:  10.1186/ar3026
PMCID: PMC2911883

Vascular alterations upon activation of TGFβ signaling in fibroblasts - implications for systemic sclerosis

Abstract

Tissue fibrosis and vascular disease are hallmarks of systemic sclerosis (SSc). Transforming growth factor β (TGFβ) is a key-player in fibroblast activation and tissue fibrosis in SSc. In contrast to fibrosis, evidence for a role of TGFβ in vascular disease of SSc is scarce. Using a transgenic mouse model with fibroblast-specific expression of a kinase-deficient TGFβ receptor type II, Derrett-Smith and colleagues demonstrate that aberrant TGFβ signaling in fibroblasts might result in activation of vascular smooth muscle cells and architectural changes of the vessel wall of the aorta.


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