PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of arthrestherBioMed Centralbiomed central web sitesearchsubmit a manuscriptregisterthis articleArthritis Research & Therapy
 
Arthritis Res Ther. 2010; 12(3): 125.
Published online Jun 18, 2010. doi:  10.1186/ar3026
PMCID: PMC2911883
Vascular alterations upon activation of TGFβ signaling in fibroblasts - implications for systemic sclerosis
Angelika Horn1 and Jörg HW Distlercorresponding author1
1Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany
corresponding authorCorresponding author.
Angelika Horn: angelika.horn/at/uk-erlangen.de; Jörg HW Distler: joerg.distler/at/uk-erlangen.de
Abstract
Tissue fibrosis and vascular disease are hallmarks of systemic sclerosis (SSc). Transforming growth factor β (TGFβ) is a key-player in fibroblast activation and tissue fibrosis in SSc. In contrast to fibrosis, evidence for a role of TGFβ in vascular disease of SSc is scarce. Using a transgenic mouse model with fibroblast-specific expression of a kinase-deficient TGFβ receptor type II, Derrett-Smith and colleagues demonstrate that aberrant TGFβ signaling in fibroblasts might result in activation of vascular smooth muscle cells and architectural changes of the vessel wall of the aorta.
Articles from Arthritis Research & Therapy are provided here courtesy of
BioMed Central