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The concentrations of plasma and synovial fluid miRNAs in RA and OA. A. Plasma concentrations of miR-16, miR-132, miR-146a, miR-155 and miR-223 in RA, OA and HC. The plasma concentration of miR-16 in OA was significantly lower than HC. The plasma concentrations of miR-132 in RA and OA were significantly lower than HC. B. Synovial fluid concentrations of indicated miRNAs in RA and OA. The concentrations of miR-16, miR-146a miR-155, miR-223 in RA were significantly higher than those in OA. Significant differences are indicated by * = P < 0.05, ** = P < 0.01.