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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
Ann Epidemiol. Author manuscript; available in PMC 2011 August 1.
Published in final edited form as:
PMCID: PMC2904957
NIHMSID: NIHMS216573

Design and Implementation of the Hispanic Community Health Study / Study of Latinos

Paul D. Sorlie, Ph.D.,1 Larissa M. Avilés-Santa, M.D., M.P.H.,1 Sylvia Wassertheil-Smoller, Ph.D.,2 Robert C. Kaplan, Ph.D.,2 Martha L. Daviglus, M.D., Ph.D.,3 Aida L. Giachello, Ph.D.,4 Neil Schneiderman, Ph.D.,5 Leopoldo Raij, M.D.,6 Gregory Talavera, M.D., M.P.H.,7 Matthew Allison, M.D., M.P.H.,8 Lisa LaVange, Ph.D.,9 Lloyd E. Chambless, Ph.D.,9 and Gerardo Heiss, M.D., Ph.D.9

Abstract

PURPOSE

The Hispanic Community Health Study (HCHS)/Study of Latinos (SOL) is a comprehensive multi-center community based cohort study of Hispanics/Latinos in the United States. Its rationale, objectives, design and implementation are described in this paper.

METHODS

The HCHS/SOL will recruit 16,000 men and women who self-identify as Hispanic or Latino, age 18-74 years, from a random sample of households in defined communities in the Bronx, Chicago, Miami and San Diego. The sites were selected so that the overall sample would consist of at least 2000 persons in each of the following origin designations: Mexican, Puerto Rican and Dominican, Cuban, and Central and South American. The study includes research in the prevalence of and risk factors for heart, lung, blood and sleep disorders, kidney and liver function, diabetes, cognitive function, dental conditions, and hearing disorders.

CONCLUSIONS

The HCHS/SOL will 1) characterize the health status and disease burden in the largest minority population in the U.S; 2) describe the positive and negative consequences of immigration and acculturation of Hispanics/Latinos to the mainstream U.S. life-styles, environment and health care opportunities; and 3) identify likely causal factors of many diseases in a population with diverse environmental exposures, genetic backgrounds and early life experiences.

INTRODUCTION

The rapid growth of the Hispanic/Latino population in the United States has underscored the need for a thorough evaluation of the health risks and disease burden in Hispanics, the impact of immigration and acculturation on health, and the causes of disease, including genetic and environmental, in a population with diverse life styles, behaviors, exposures, ethnicities and places of origin. The terms Hispanic or Latino are used interchangeably in this paper to refer to populations who self-identify in this manner. The Hispanic/Latino population grew from 22.4 to 35.3 million persons from 1990 to 2000, became the largest minority in the U.S. in 2003, and is expected to triple by 2050 (1,2). Despite increasing obesity and diabetes, and a generally lower socioeconomic status, cardiovascular mortality is often observed to be lower in Hispanics/Latinos, a pattern often referred to as the Hispanic Paradox (36). Data show that the longer Hispanic/Latino immigrants live in the U.S., the worse some cardiovascular risk factors become (7). The diversity by country of origin may influence disease risk by varying degrees, as suggested by the differing levels of some risk factors and some morbidities observed in Hispanics/Latinos of different countries of origin (810).

In response to a working group in 2003 titled “Epidemiologic Research in Hispanic Populations; Opportunities, Barriers and Solutions” (11), the National Heart, Lung and Blood Institute (NHLBI) initiated in 2006 the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). To maximize productivity and scientific opportunities that could be realized within the HCHS/SOL, scientific direction and financial resources were also obtained from six other Institutes or Centers within the National Institutes of Health (National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements). This paper describes the objectives, design, content and implementation of this landmark study that addresses cardiovascular disease, stroke, asthma, chronic obstructive lung disease, sleep disorders, dental caries and periodontal disease, hearing impairment and tinnitus, diabetes, kidney and liver disease, and cognitive impairment. The protocol and manuals of operation are found in the study web site (12).

MATERIALS AND METHODS

The HCHS/SOL has the following specific operational objectives:

  1. To identify, sample and recruit up to 4000 persons who self identify as Hispanics or Latinos, age 18–74 years, from each of four communities in the US with a stable population and strong community structure (a total of up to 16,000 persons) with participants from each of the following origins: Mexican, Cuban, Puerto Rican and Dominican, and Central and South American.
  2. To conduct a detailed and standard characterization of these study participants including questionnaires and procedures to characterize chronic conditions and their putative antecedent factors.
  3. To conduct an annual follow-up telephone contact of study participants.
  4. To identify new coronary heart disease, stroke, heart failure, and chronic obstructive lung disease events that require hospitalization following the initial examination; to identify acute exacerbations of asthma or chronic obstructive pulmonary disease requiring emergency department care or hospitalization; to identify deaths; to review and adjudicate medical information from hospital, physician and other records.
  5. To develop innovative hypotheses, perform data analysis, and disseminate findings through publications from this study.
  6. To provide community education and feedback based on the study findings that will improve the health of the communities.
  7. To provide opportunities for collaboration with the wider community of scientists and publicize the potential for such opportunities.
  8. To provide opportunities for career development and research experience for minority investigators.

The HCHS/SOL is a prospective, population based, cohort study consisting of a baseline examination lasting approximately 7 hours, a follow-up telephone call within 6 weeks with a second 24-hour dietary recall, and annual follow-up telephone calls to ascertain any hospitalizations and other significant clinical events and to update participants’ contact information. The first annual call also includes a food propensity interview to assess dietary patterns. Health events that occur during the follow-up are identified, relevant medical records obtained, and clinical events reviewed and evaluated according to predefined criteria. Recruitment and examination of study participants will last approximately three years, and follow-up and identification of clinical events will continue for an average of three years in this contract period. IRB approval has been obtained institutions at each field center and the coordinating center.

Community Description and Involvement

The four communities included in the HCHS/SOL are located in the Bronx, NY; Chicago, IL; Miami, FL; and San Diego, CA. These field centers were selected based on the peer review of study proposals and with consideration of geographical balance and place of origin. A more detailed description of the sites and maps of their location can be found in the manual of operations (12). The population numbers presented in the next paragraphs are estimates based on the 2005–2007 American Community Survey (13).

The Bronx is home to about 700,000 Hispanic/Latino individuals, representing 51% of the approximately 1.4 million Bronx residents (13). Puerto Ricans are the most represented Hispanic/Latino subgroup in the Bronx constituting 46% of Hispanic/Latinos, followed by Dominicans at 31%, Mexicans at 9%, and the remaining groups combined at 14%. Recruitment is conducted throughout the Bronx in census tracts that were selected based upon the goal of socioeconomic diversity and accessibility to the HCHS/SOL clinical center.

The city of Chicago has over 700,000 individuals of Hispanic/Latino origin, representing nearly 30% of the estimated 2.7 million residents (13). Persons of Mexican origin constitute the majority of Hispanics/Latinos (73%), followed by Puerto Ricans (14%), and the remaining groups combined at 13%. The targeted area for recruitment in Chicago is composed of ethnically diverse neighborhoods including several that have been majority Hispanic/Latino for decades and others with more recent Hispanic/Latino in-migration.

Miami-Dade County, Florida has about 2.4 million residents of which 1.5 million are of Hispanic/Latino origin (13). Persons of Cuban origin represent 52% of Hispanics, followed by South American (16%), Central American (14%), and the remaining groups combined at 18%. Recruitment is being conducted in the southwest section of Miami-Dade County and in Hialeah.

San Diego County has a population of about 3 million with 30% of Hispanic/Latino origin (13). The vast majority (88%) are of Mexican origin with 12% in the remaining groups combined. The combined region of South Suburban (54% Hispanic/Latino) and South Central (38% Hispanic/Latino) San Diego County, commonly referred to as the “South Bay” is the target community.

The HCHS/SOL was developed recognizing the importance of community participatory research requiring community involvement throughout the study (14). Each field center has a community advisory board that meets on a regular basis to provide advice on a wide range of community issues related to the study. Community members have provided input and advice on the informed consent, questionnaire development, Spanish translation, and issues related to community sensitivities and values.

Participant Sampling and Recruitment

The sampling design was established to support two analytical objectives: first to estimate the prevalence, mean values and distribution of risk factors, with sufficient sample size to stratify by place of origin and other relevant demographic characteristics; and second to evaluate relationships among baseline risk factors, and relationships of baseline risk factors with disease outcomes. Representative samples of participants are drawn from census tracts in these defined communities and are recruited from households using strategies that maximize participation rates, minimize non-response, and minimize attrition during follow-up. The study was conceptualized with recognition that community involvement was essential for its success, thus a community defined sample was needed rather than a sample drawn from very wide geographical areas. Recruitment involves intensive community publicity and direct contract from recruiters. A bilingual study web site is available for the public and participants (www.saludsol.net) individualized to each field center. The detailed sampling design and recruitment strategies are described in the companion article (LaVange, L., et. al., Submitted to the Annals of Epidemiology as a companion paper to this one).

Examination Overview

Each field center has a specialized examination site accessible to the sampled community. All sites are convenient to public transportation and provide a van service or taxi service to assist participant attendance. Participants are reimbursed for expenses involved in attending the examination. Persons are excluded from the study if they have plans to move from the region within six months, are unable to travel to the field center, or are unable to complete the study questionnaires in English or Spanish. Women who are pregnant are rescheduled for a visit approximately 3 months post partum. All staff are bilingual allowing the use of Spanish or English at the preference of the participant. All forms and questionnaires are in both languages.

The baseline examination averages seven hours in length, with variation associated with the age and health condition of the participant. Since a fasting blood draw is required, examinations begin in the morning. At the reception, participants are welcomed, and informed consent is obtained. Participants are asked to bring medications to the study center where these are recorded.

Table 1 details the standardized examination content and its typical flow and duration, though the sequence may vary by field center. The examination includes a series of fixed and flexible components that are organized to accommodate first the collection of informed consent prior to any data collection, followed by the collection of measurements that must be obtained in the fasting state, followed by a glucose screening test to determine eligibility for a glucose load. The fast is broken by a snack at the appropriate time in the examination. Participant safety is paramount and some procedures are not performed if contraindicated (e.g., glucose tolerance test, albuterol challenge during pulmonary testing, and a periodontal examination). Neurocognitive testing and the ankle-brachial blood pressure measures are not performed in those less than age 45 years. Complete documentation of the examination content, questionnaires, forms, and a manual of procedures are available at the study web site (15).

Table 1
Example of HCHS/SOL Baseline Interview and Procedure Blocks

Questionnaire Content

The questionnaires and a brief description of their content can be found in Table 2. Questionnaires are interviewer-administered and collect participant identification, location and contact information; health and medical history including cardiovascular and pulmonary diseases, sleep habits and disorders, hearing loss or tinnitus, use of hearing aids, noise exposure, and oral/dental health; social and behavioral factors and support including family structure and community involvement, association with religious and other social organizations, education, and traditional and/or Hispanic/Latino values; occupational history including occupational risk factors potentially related to cardiovascular and lung diseases, cancer, and hearing loss; disability; access to health care and use of health care facilities; smoking history and passive smoke exposure; alcohol consumption, and current physical activity. Dietary intake is ascertained using a 24-hour dietary recall at the initial examination and again six weeks later. A food propensity questionnaire developed to include Hispanic/Latino foods is administered during the first year annual follow-up call. If not previously translated through a well-described and standard process, questionnaires were newly translated into Spanish, certified by an independent translator, and tested by focus groups at each field center to identify relevant differences in word usage by nationality or region of origin.

Table 2
Components of the Examination

Examination Procedures

The baseline examinations are outlined in Table 2. Weight, height, and abdominal and hip girth are measured with participants wearing light clothing, as is an efficient measure of bio-impedance to estimate body fat composition. Standard resting brachial blood pressure is measured three times in the seated position with a tested, automated sphygmomanometer (Omron model HEM-907 XL). To obtain the ankle and brachial blood pressure index, blood pressure is assessed bilaterally in the brachial, dorsalis pedis and posterior tibial arteries with a Doppler probe. Digitized records of a standard digital 12-lead ECG and a two-minute rhythm strip are obtained and results processed at a central ECG reading center. Standard digitized spirometric measurements of timed pulmonary function (forced vital capacity or FVC, the forced expiration volume in one second or FEV1, and the ratio between these two values, FEV1/FVC) are obtained using the SensorMedics model 1022 dry-rolling seal volume spirometer. Participants whose first spirometric test indicates impaired lung function undergo repeated spirometry testing after inhaling a bronchodilator to determine if the airway obstruction is reversible. An oral examination is conducted to measure periodontal disease and other dental conditions. The hearing examination includes otoscopy and assessment of hearing loss using measures of acoustic immittance and pure tone audiometry. Testing is conducted in a sound-treated booth using TDH-50 earphones and a clinical audiometer in a manner consistent with the guidelines of the American Speech-Language-Hearing Association. Testing protocols for the dental and hearing components are comparable to those used in the NHANES.

Cognitive performance measures include a six-item screener, the Spanish English Verbal Learning Test, the Word Fluency Test of the Multilingual Aphasia Examination, and the Digit Symbol Substitution Test of the Wechsler Adult Intelligence Scale-Revised (WAIS-R). These measures tap five cognitive domains: global mental status, verbal learning and memory, word fluency, and psychomotor speed, respectively.

Following the visit to the study examination center, participants are requested to wear a portable motion sensor (ActicalTM accelerometer, model 198-0200-03, Minimiter Respironics®, Bend, OR) to measure actual physical activity for a period of 7 days. The Actical device measures the occurrence and intensity of motion in all directions and sums and stores the signals as “activity counts.” To assess any sleep disturbances participants wear an Apnea Risk Evaluation System (ARES) Unicorder for one night. This device uses a novel pulse oximeter measuring oxygen saturation and heart rate, and sensors which measure airflow, snoring sounds (by microphone), and head movement and body position (by accelerometry) and enables computation of the apnea hypopnea index (AHI).

Blood and urine specimens are collected at each site according to the standardized protocol. Daily fresh and frozen specimens are shipped to the central laboratory for measurements outlined in Table 3. A urine sample is collected from participants preferably at the beginning of the exam for measurement of albumin and creatinine. Fasting blood is collected soon after arrival, and a second collection is done following a 2 hour glucose tolerance test. After the post-load venipuncture, participants are provided with a snack. Approximately 80 ml of blood are collected. A repository of plasma, serum, genomic DNA, RNA and urine is established at the central laboratory for future analysis. Details on the laboratory collection, processing and analysis can be found in the laboratory manual (16).

Table 3
Components of the Blood, Urine, and Laboratory Measurements

Data Collection, Management and Quality Assurance

All data are collected using a direct computer based data entry system developed and programmed by the Coordinating Center. Intermediate paper forms are not used with the exception of field center routing and scheduling forms, neurocognitive tests that are not designed for computer based administration, and back-up forms to allow for computer or internet malfunctions. Online editing takes place at the time of data entry so that queries can be made of participants and errors corrected immediately.

Quality assurance includes central training of all staff; standardized certification of the staff inclusive of recruiters; direct observational monitoring of the recruitment, examination procedures, administration of the interview, and equipment calibration schedules; within visit repeat measurements of both laboratory and procedures to determine measurement variability; and analysis of all collected data to identify errors in measurement or questionnaire administration.

Central Laboratory and Reading Centers

To standardize the examination and measurement process across study sites, a central laboratory and central reading centers serve as foci for protocol development, training and certification of staff, centralized measurements or readings, and quality assessment and control. The Central Laboratory established the uniform blood processing and shipping procedures, conducts all laboratory assays, implements blind replicate measurements for a 5% sample, conducts measurements of blinded samples from standardized samples, provides technical support to the field centers and transfers the study results to the coordinating center. Equivalent training, standardization, reading, and quality control functions are also conducted by the Pulmonary Function Testing Reading Center, the Central Electrocardiogram Reading Center, the Sleep Reading Center (for the overnight sleep monitors), the Audiometry Reading Center, the Nutrition Reading Center (for the 24-hour dietary recall and food propensity questionnaires), and a Neurocognitive Center (for the neurocognitive performance tests).

Participant Follow-up

Following the examination and completion of laboratory tests, participants are provided with a summary of their study results of established medical value. Interpretation of the results per current guidelines and pertinent recommendations are provided. Working with its community advisory committee the study assists participants who do not have a health care provider in obtaining a medical referral. Each field center has a network of free or sliding fee scale providers to assist those without medical insurance.

Participants are contacted by telephone approximately 6 weeks after the baseline visit to obtain a second 24-hour dietary recall. One year after the baseline visit, participants are again contacted by telephone to obtain information on any change in personal contact information, as well as doctor visits, emergency care, or hospitalization since baseline. Following the NHANES procedures, a food propensity questionnaire also is administered (similar to a food frequency questionnaire, but without information on the portion size consumed) to elicit information on consumption of certain foods during the previous year (17).

Endpoint Ascertainment and Classification

During the annual follow-up phone call, deaths, hospitalizations, and emergency department visits of participants that occur from the baseline examination through the end of the follow-up period are identified. Information relevant to the classification of study outcomes are abstracted from the medical records by trained personnel. Events are classified according to study protocol (18) as a combination of computer-based algorithms and an overview of the medical records by a panel of clinical specialists trained in the HCHS/SOL classification criteria. The HCHS/SOL event classification criteria were selected for comparability to those of other pertinent epidemiologic studies. The cardiovascular endpoints include myocardial infarction, fatal coronary heart disease, heart failure, and stroke. Additionally, the study will ascertain exacerbations of asthma that result in an emergency department or hospital visit, and hospitalizations and emergency department visits for chronic obstructive pulmonary disease. Deaths are identified from reports by next-of-kin, obituary searches and matches to the National Death Index. A summary of the criteria for these endpoints are shown in Table 4.

Table 4
Endpoint Events and Criteria

Study Governance and Oversight

A Steering Committee (consisting of the principal investigators of each field center, the principal investigator of the coordinating center, and the project officer of the NHLBI) provides the scientific and procedural direction for the HCHS/SOL. Reporting to the Steering Committee are the following committees: Ancillary Studies, Publications, Community Relations, Endpoints, Operation/Examination, Retention/Follow-up, Sampling/Recruitment, Translation/Validation, Quality Control, Questionnaires, and Career Development.

The HCHS/SOL is conducted under the oversight of each institutional review board (IRB) at the field centers and coordinating center institutions. The study has an Observational Studies Monitoring Board that serves as advisory to the NHLBI and provides oversight on participant burden, safety, study progress and reviews all ancillary studies. As a study funded by Federal contracts the data collection forms received clearance from the Office of Management and Budget (OMB). The table in the appendix describes each institution and staff involved in the HCHS.

DISCUSSION

While the HCHS/SOL is the most comprehensive study of Hispanics/Latinos in the United States to date, limitations exist. First, while the community based sampling design will permit inferences to the larger population from which it is drawn, inferences cannot be made regarding prevalence of risk factors or disease to the larger Hispanic Community across the U.S. Since many of the procedures have also been conducted by the NHANES and other studies, the HCHS/SOL will conduct analysis to compare to these other studies. Second, while the study aims to investigate the “Hispanic Paradox,” this requires comparison to non-Hispanic populations. However, a non-Hispanic cohort was not included in this study. Consequently, comparisons to non-Hispanic populations will be based on the use of common protocols with other studies, principally the Multi-Ethnic Study of Atherosclerosis and other NHLBI epidemiology cohorts. For research components missing from the core study, there is an ancillary study process to encourage additional grant support. Ancillary study procedures and policies can be found on the HCHS web site (19).

The HCHS/SOL is designed to inform health care providers, the public health community, and the Hispanic/Latino population on the frequency of impaired health in Hispanics/Latinos, the likely causes associated with these conditions and the measures needed to promote the health of the Hispanic/Latino population in the U.S. Though not a national sample, it will provide comprehensive information on risk factors and burden of disease outcomes of significant breadth. Knowledge from this study will also provide understanding of the consequences of major changes in life-style and health care due to immigration. The resulting information will not only improve the health of Hispanics or Latinos, but can lead to measures resulting in improved health for the U.S. population at large.

Acknowledgments

The HCHS/SOL study acknowledges the complete team of personnel list below for their dedication and commitment to the success of this study.

HCHS Institutions and Staff

Field Centers

Bronx Field Center – Albert Einstein School of Medicine

Investigators, Managers and Coordinators

  • Robert Kaplan, Principal Investigator
  • Sylvia Wassertheil-Smoller, Co-Principal Investigator, (former Principal Investigator)
  • Raanan Ahrens, Co-Investigator
  • Victor Badner, Co-Investigator
  • Janice Barnhart, Co-Investigator, Medical Director
  • Elizabeth Dinces, Co-Investigator
  • Mindy Ginsberg, Co-Investigator
  • Carmen Isasi, Co-Investigator
  • Elizabeth Lee-Rey, Co-Investigator
  • Yasmin Mossavar-Rahmani, Co-Investigator
  • Robert Ostfeld, Consulting Cardiologist
  • Christian Schumacher, Co-Investigator
  • Adelyn Alvarez, Community and Outreach Coordinator (former)
  • Emelinda Blanco, Recruitment Manager
  • Jessica Clemente, Community Outreach & Follow-Up Manager
  • Madeline Crespo-Figueroa, Clinic Manager
  • Rosalyn Graves, Nurse Manager / Clinic Nurse
  • Yvonne Raiford, Director of Research
  • Elena M. Stefanizzi, Administrator
  • Laura Tocci, Audiologist
  • Gladys Valdivieso, Community Liaison
  • Nancy Flores, Senior Recruiter
  • Jhack Sepulveda, Lead Nutritionist
  • Maria Rocio-Gilman, Lead Interviewer
  • Lizette Rosario, Lead Medical Technician
  • Mary Valle, Outcomes Coordinator

Clinic, Laboratory, Recruitment, and Administrative Staff

  • Laura Avelino
  • Carlos Blanco
  • Rainey Cruz
  • Bernandino Diaz
  • Jose Guzman
  • Sherifa Heron
  • Aleny Lora
  • Jose Luciano
  • Rafael Martinez
  • Alejandro Molina
  • Wanda Pacheco
  • Ruth Santizo
  • Evelyn Torres-Ferrara
  • Joel Valez
  • Christine Abreu
  • Marisol Castellano
  • Yanette Fuentes
  • Shir Lerman
  • Marlen Murillo
  • Leonides Ramos
  • Marilyn Colon
  • Zenobia Colon
  • Jacqueline Martinez
  • Gregory Adinov
  • Kwabena Bosompem
  • Minerva Foglia
  • Sofia Kavakoglou
  • Phyllis Marti
  • Natasha Muriel
  • Vanessa Sessoms
  • Darwin Tracy
  • Myra Davila
  • Maria Fan
  • Rahul Kulkami
  • Claire Montaigne
  • MariaAntonia Rodriguez

Chicago Field Center – All listed are from Northwestern University unless identified as UIC (University of Illinois Chicago)

Investigators, Managers and Coordinators

  • Martha L. Daviglus, Principal Investigator
  • Aida L. Giachello, Co-Principal Investigator (UIC)
  • Kiang Liu, Co-Principal Investigator
  • Karen Mancera-Cuevas, Study Coordinator
  • Susan Giovanazzi, Clinic Manager
  • Duanny Alva, Assistant Clinical Coordinator
  • Claudia Chambers, Assistant Clinical Coordinator
  • Louis Martos, Assistant Clinical Coordinator
  • Mayra Vargas, Assistant Clinical Coordinator
  • Catalina Ramos, Recruitment Manager (UIC)
  • Rigoberto Angulo, Recruitment Field Coordinator (UIC)
  • Jesse Cano, Recruitment Field Coordinator (UIC)
  • Jeannie B. Concha, Recruitment Field Coordinator (UIC)
  • Sylvia Gutierrez, Assistant Recruitment Field Coordinator
  • Francisco Moreno, Recruitment Field Coordinator (UIC)
  • Rosemary George, Recruitment Grant Manager (UIC)
  • Daniel B. Garside, Research Programming Manager
  • Niki Gernhofer, Nutrition Supervisor
  • Natalie Meza, Community Relations and Outreach Coordinator (UIC)
  • Angela Herrell, Research Administrator
  • Sujata Archer, Investigator
  • David W. Baker, Investigator
  • Virginia Bishop, Investigator
  • Jose Arrom, Investigator (UIC)
  • Mercedes Carnethon, Investigator
  • James P. Choca, Investigador
  • Pablo Denes, Investigator
  • Sumitrajit Dhar, Investigator
  • Pamela Fiebig, Investigator
  • David Green, Investigator
  • Donald Lloyd-Jones, Investigator
  • Mary McDermott, Investigator
  • Sanjiv Shah, Investigator
  • Lewis Smith, Investigator
  • Jeremiah Stamler, Investigator
  • Lu Tian, Investigator
  • Linda Van Horn, Investigator
  • Phillis Zee, Investigator
  • Shirley Beaver, Consultant
  • Patricia Canessa, Consultant
  • Victoria Persky, Consultant
  • Esther Sciamarella, Consultant
  • Rosemary Sokas, Consultant

Clinic, Laboratory, Recruitment, and Administrative Staff - UIC

  • Adriana Garcia
  • Marc Noble
  • Christian Rodriguez
  • Veronica Angulo
  • Ericka Garduno
  • Ricardo Corcoles
  • Rebecca DaVila
  • Paula Rodriguez
  • Karina Vera
  • Adela Busso
  • Cesar Alvarado
  • Chantal Payano
  • Aracelis Englund
  • Martha Prado Gonzalez
  • Lourdes Garduno
  • Armando Saleh
  • Victor Abundis
  • Consuelo Garcia Herreros
  • Pablo Gomez
  • Jessica Luna Ramos
  • Cassandra Rodriguez
  • Diana Silva
  • Jeannette Marchan
  • Abel Rosas
  • Manuel Abundis
  • Araceli Cisneros
  • Gonzalo Lozano
  • Pablo Bernhardt
  • Reynaldo Guerrero
  • Rosario Delgado

Clinic, Laboratory, Recruitment, and Administrative Staff - NU

  • Liliana Bolanos
  • Gabriella Bovio
  • Juan Pablo Correa
  • Olga Garcia
  • Jose Garcia
  • Georgette Garside
  • Mary Harris
  • Dolores Lopez
  • Liliana Medina
  • Cheryl Westbrook
  • Maybelline Pereda
  • Evita Sanchez
  • Sandra Valdez
  • Soraya Valencia
  • Delia Vazquez

Miami Field Center – University of Miami

Investigators, Managers and Coordinators

  • Neil Schneiderman, Program Director/Principal Investigator
  • David Lee, Co-Principal Investigator
  • Leopoldo Raij, Co-Principal Investigator
  • John Ryan, Co-Principal Investigator
  • Marc Gellman, Project Manager
  • Brendaly Rodriguez, Recruitment and Outreach Manager
  • Melanie Ashby- Laboratory manager
  • Maria Pattany, Clinic Manager
  • Robert Fifer, Investigator
  • Jesus Gomez, Investigator
  • Maria Llabre, Investigator
  • Armando Mendez, Investigator
  • Frank Penedo, Investigator
  • Matthias Salathe, Investigator
  • Ralph Sacco, Investigator
  • Daniel Santisteban, Investigator
  • Gail Shor-Posner, Investigator
  • Lisa Baumbach-Investigator
  • David Seo- Investigator
  • William Wohlgemuth- Investigator
  • William Arguilles- Predoctoral Fellow

Clinic, Laboratory, Recruitment, and Administrative Staff

  • Amy Arriaga
  • Jenny Bellof
  • Marcela Castiglion
  • Nora Cobo
  • Nayomy Figueroa
  • Blair HallMartica Hall
  • Elsa Hernandez
  • Edda Jiron
  • Tilky Lopez- Blanco
  • Eleana Mendes
  • Silvia Mirabel
  • Mairim Mise
  • Roberto- Monzano
  • Juan Moreiras
  • Ester Parra
  • Nubia Pelusso
  • Andre Perwin
  • Katherine Pozo
  • Conchita Ramos
  • Omar Rivero
  • Ralph Sacco
  • Daniel Suarez
  • Lionel Vera
  • Feng Zhao

San Diego Field Center – All listed are from San Diego State University unless identified as UCSD (University of California San Diego), or SYHC (San Ysidro Health Center)

Investigators, Managers and Coordinators

  • Greg Talavera, Principal Investigator
  • John Elder, Co-Principal Investigator
  • Matthew Allison, Co-Principal Investigator (UCSD)
  • Michael Criqui, Co-Principal Investigator (UCSD)
  • Ana Talavera, Program Manager
  • Julie Denenberg, Data Management (UCSD)
  • Rocio Gonzalez-Beristain, Program Manager (SYHC)
  • Guadalupe X. Suchi Ayala, Investigator
  • Elva Arredondo, Investigator
  • Brian Finch, Investigator
  • Linda Gallo, Investigator
  • Ming Ji, Investigator
  • Cindy Knott, Investigator
  • James Sallis, Investigator
  • Peter Torre, Investigator
  • Steven Edleman, Investigator (UCSD)
  • Jeffery Johnson, Investigator (UCSD)
  • Jose Loredo, Investigator (UCSD)
  • Brenda Money, Investigator (UCSD)
  • Ira Parker, Investigator (UCSD)
  • Andrew Ries, Investigator (UCSD)
  • Cheryl Rock, Investigator (UCSD)
  • Leonel Villa-Caballero, Investigator (UCSD)
  • Karen Becerra, Investigator (SYHC)
  • Jonathon Rudin, Research (SYHC)
  • Rick Cuadra, Research (SYHC)
  • Paulina Martinez, Graduate Student
  • Vanessa Torres, Graduate Student (SYHC)

Clinic, Laboratory, Recruitment, and Administrative Staff

  • Johanne Blouin-Hernandez
  • Blanca Carrillo
  • Yasmina Cortez
  • Philippe Duhaime
  • Martha Muñiz
  • Alejandra Oceguera
  • Bianca Perdomo
  • Tanya Perdomo
  • Maria Del Carmen Porras
  • Nora Ramirez
  • Patricia Richardson
  • Gerald Rivera
  • Maria Luisa Rivera
  • Izzybeth Rodriguez
  • Diana Romero
  • Elizabeth Sanchez
  • Maria Mercedes Sierra
  • Uribe Lizette
  • Carlos Vera
  • Sylvia Andrade
  • Elizabeth Flores
  • Andrea Hernandez
  • Cecilia Lopez
  • Guillermina Macias
  • Luis Miquirray
  • Karla Nuñez
  • Elizabeth Pastrana
  • Rosalinda Rodriguez
  • Gabriela Villavicencio
  • Esthela Escobar
  • Hiram Cardozast
  • Tanya Cornejo
  • Jessica Gomez-Padilla
  • Rodrigo Leon-Alvarez
  • Carmen Lopez
  • Tanya Lopez
  • Martha Navarro

Coordinating Center – University of North Carolina

Department of Biostatistics, Gillings School of Global Public Health Collaborative Studies Coordinating Center

  • Lisa LaVange, Principal Investigator
  • Gerardo Heiss, co-Principal Investigator
  • Diane Catellier, co-Principal Investigator
  • Shrikant Bangdiwala, co-Investigator
  • James Beck, co-Investigator
  • Lloyd Chambless, co-Investigator
  • William Kalsbeek, co-Investigator
  • Krista Perreira, co-Investigator
  • Barry Popkin, co-Investigator
  • Wayne Rosamond, co-Investigator
  • Anna Maria Siega-Riz, co-Investigator
  • June Stevens, co-Investigator
  • Eric Whitsell, co-Investigator
  • Marston Youngblood, Project Manager
  • Franklyn Gonzalez, Statistician
  • Paula Gildner, Research Specialist
  • Jeff Oberhaus, Research Assistant
  • Hope Bryan, IT Manager
  • Kathy Roggenkamp, Statistical Computing Manager

Central Laboratory – University of Minnesota

John H. Eckfeldt, M.D., Central Laboratory Principal Investigator

Bharat Thyagarajan, Central Laboratory Co-investigator

Catherine Leiendecker-Foster, Project Manager

Central Reading Centers

Audiometry Center - University of Wisconsin

  • Karen J. Cruickshanks, Principal Investigator
  • Ted S. Tweed, Co-investigator
  • Dayna S. Dalton, Co-Director
  • Thomas Dugolenski, Audiologist

ECG Reading Center – Wake Forest University

  • Elsayed Soliman, Principal Investigator
  • Zhu-Ming Zhang, Co-Investigator

Neurocognitive Reading Center – University of Mississippi Medical Center

  • Thomas Mosley, Principal Investigator
  • Margaret Pearson, Statistician
  • Christianne Pinell-Jansen, Psychometrist

Nutrition Reading Center – University of Minnesota

  • John H. Himes, Principal Investigator
  • Lisa Harnack, Co-investigator
  • Mary Stevens, Service Center Manager
  • Aida Miles, Project Nutritionist
  • Susan Seftik, Quality Control
  • Brenda Nolan, Assistant Project Nutritionist
  • Janet Pettit, Database Nutritionist

Pulmonary Reading Center – Columbia University

  • R. Graham Barr, Principal Investigator
  • John Hankinson, Co-Investigator
  • Paul L. Enright, Co-Investigator

Sleep Center – Case Western Reserve University

  • Susan Redline, Principal Investigator
  • Sanjay Patel, Co-Investigator

National Heart, Lung and Blood Institute

Project Office

  • Larissa Avilés-Santa, Project Officer
  • Paul Sorlie, Deputy Project Officer, Project Officer (former)
  • Lorraine Silsbee, Deputy Project Officer
  • Phyliss Sholinsky, Deputy Project Officer (former)
  • Cay Loria, Nutritionist
  • George Papanicolaou, Geneticist

Contract Office

  • Kristi Cooper, Contract Officer
  • Elizabeth Zoller, Contract Specialist

National Institutes of Health Co-funding Institutes/Centers/Offices

National Center on Minority Health and Health Disparities

Nathanial Stinson, Project Officer

National Institute of Deafness and Other Communications Disorders

Howard Hoffman, Project Officer

National Institute of Dental and Craniofacial Research

Jane Atkinson, Project Officer

National Institute of Diabetes and Digestive and Kidney Diseases

Paul Eggers, Project Officer

National Institute of Neurological Disorders and Stroke

Claudia Moy, Project Officer

Office of Dietary Supplements

Mary Frances Picciano, Project Officer

Funding

The Hispanic Community Health Study/Study of Latinos was supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements.

Footnotes

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