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From:
Published online 2010 May 8. doi: 10.1208/s12249-010-9434-8

Table III

Moisture Loss (%) Data by TGA for Levothyroxine Sodium Pentahydrate and Dehydrated Form Under Various Stability Conditions

ConditionsDays
036101428
Pentahydrate form
25°C/60%RH9.77 ± 0.079.69 ± 0.099.77 ± 0.168.81 ± 1.619.59 ± 0.509.48 ± 0.67
25°C/0%RH9.77 ± 0.078.31 ± 2.059.30 ± 0.246.06 ± 0.717.64 ± 1.128.52 ± 0.19
40°C/75%RH9.77 ± 0.0710.12 ± 0.1810.26 ± 0.179.43 ± 1.1310.16 ± 0.379.96 ± 0.50
40°C/0%RH9.77 ± 0.078.86 ± 0.248.01 ± 0.488.21 ± 0.337.35 ± 0.167.24 ± 0.33
Dehydrated forma
25°C/0%RH7.213.06N/Ab N/Ab 3.912.62
40°C/0%RH7.212.254.534.654.772.99

The results are expressed as average ± SD for n = 3

aFor dehydrated form n = 1

bData not available due to instrument error