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Journal of Cardiovascular Translational Research
Published online 2010 February 25. doi: 10.1007/s12265-010-9170-1

Table 2

Advantages and disadvantages of PET, MRS, and SPECT in evaluation of myocardial metabolism

PETQuantitative metabolic and blood flow measurements; high sensitivity; radiotracers as natural substrates and chemical analogs; many metabolic radiotracers availableCyclotron needed on site due to short half lives; only one process can be evaluated at a time; difficulty with separating reaction steps in a pathway
MRSSimultaneous measurements of multiple metabolic pathways and function; ease in performing serial measurements, no ionizing radiation; higher field strength in small animal imagingPoor sensitivity (millimolar); low signal to noise ratio; intravoxel signal contamination; long acquisition times; measurement limited to anterior wall in humans
SPECTHigh sensitivity; widely available; long half lives facilitate radiopharmaceutical delivery; simultaneous imaging of two radiopharmaceuticals with different energies; ECG gating for myocardial functionInability to quantify processes with lack of attenuation correction; poor temporal and spatial resolution; few radiopharmaceuticals available for evaluation of metabolism