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Previous studies have shown that neighborhood factors are associated with obesity, but few studies have evaluated the association with weight control behaviors. This study aims to conduct a multi-level analysis to examine the relationship between neighborhood SES and weight-related health behaviors.
In this ancillary study to Look AHEAD (Action for Health in Diabetes) a trial of long-term weight loss among individuals with type 2 diabetes, individual-level data on 1219 participants from 4 clinic sites at baseline were linked to neighborhood-level data at the tract level from the 2000 US Census and other databases. Neighborhood variables included SES (% living below the federal poverty level) and the availability of food stores, convenience stores, and restaurants. Dependent variables included BMI, eating patterns, weight control behaviors and resource use related to food and physical activity. Multi-level models were used to account for individual-level SES and potential confounders.
The availability of restaurants was related to several eating and weight control behaviors. Compared to their counterparts in neighborhoods with fewer restaurants, participants in neighborhoods with more restaurants were more likely to eat breakfast (prevalence Ratio [PR] 1.29 95% CI: 1.01-1.62) and lunch (PR = 1.19, 1.04-1.36) at non-fast food restaurants. They were less likely to be attempting weight loss (OR = 0.93, 0.89-0.97) but more likely to engage in weight control behaviors for food and physical activity, respectively, than those who lived in neighborhoods with fewer restaurants. In contrast, neighborhood SES had little association with weight control behaviors.
In this selected group of weight loss trial participants, restaurant availability was associated with some weight control practices, but neighborhood SES was not. Future studies should give attention to other populations and to evaluating various aspects of the physical and social environment with weight control practices.
It is estimated that 97 million adults in the United States are either overweight or obese . Obesity, defined as a body mass index (BMI) of 30 kg/m2 or higher in adults, is a complex disease that arises from interactions between multiple genes, as well as behavioral and environmental factors . Furthermore, obesity is a serious risk factor for many chronic conditions (diabetes, hypertension, hypercholesterolemia, stroke, heart disease, certain cancers, and arthritis) and has been reported to markedly decrease life expectancy [2-4]. The prevalence of obesity was relatively stable between 1960 and 1980, but has dramatically increased over the past 20 years . Although the health risks of obesity are well established, there is less certainty about the management of the disease. Lifestyle modification programs to address obesity prevention and weight loss have achieved only moderate success, particularly interventions for long-term weight loss .
New public health approaches to the obesity problem are urgently required. One factor that may play a role in the risk of obesity is the neighborhood environment [7,8]. Neighborhood socioeconomic conditions are known to affect health even after controlling for individual-level socio-demographic factors [9-11]. Recent data suggests that the neighborhood environment may influence risk of chronic diseases such as cardiovascular disease, type 2 diabetes, and related health behaviors such as decreased levels of physical activity [12-22]. A few studies have demonstrated that living in neighborhoods with low socio-economic status (SES) is associated with an increased risk of obesity [23,24]. However, there are few data on neighborhood and weight-control behaviors. Investigating novel correlates of weight control is necessary given there is overwhelming evidence showing that weight loss is associated with marked improvement in health status, particularly, blood pressure and glucose control [25-27].
Therefore, we conducted a multi-level analysis to examine the relationship between neighborhood SES and weight-related variables at baseline among overweight participants with type 2 diabetes enrolled in the Look AHEAD study. We hypothesized that: 1) poorer neighborhood SES would be associated with poorer eating patterns and weight control behaviors independent of individual-level socio-economic status and 2) more availability of stores with healthy options (i.e. food stores) in the neighborhood would be associated with better eating patterns and weight control behaviors independent of individual-level socio-economic status.
The primary objective of the Look AHEAD study  is to examine, in overweight volunteers with type 2 diabetes, the long-term effects of an intensive lifestyle intervention program designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity. The intervention group is compared to a control condition involving a program of diabetes education and support. The primary basis for the comparison is the incidence of serious cardiovascular events. Other outcomes, including cardiovascular disease risk factors, diabetes-related metabolic factors and complications, and the cost-effectiveness of the intensive intervention are also studied. Participants are 5,145 volunteers with type 2 diabetes who are 45-75 years of age and overweight or obese (body mass index [BMI] ≥ 25 kg/m2).
This ancillary study was conducted at baseline using Look AHEAD participants at 4 clinical sites; Baltimore(n = 302), Philadelphia(n = 293), Pittsburgh(n = 321), and New York(n = 303). Sites were chosen because of their close geographic proximity and similar demographic profile. The total study sample for this ancillary consists of 1219 participants with complete data on neighborhood environment. Addresses were used to identify the corresponding census tracts for each participant (neighborhood) as defined by the 2000 Census using a process called geocoding and software program ArcGIS™. The program matches imported addresses to geographic maps and other geographic data. Matches are rated with scores from 0 (no match) to 100 (perfect match); we accepted matches with 80% certainty or more. Once we identified the census tracts and corresponding data for each participant, these data were linked to the individual-level data collected during the Look AHEAD trial. A description of all of the main variables used in this analysis is summarized in Table Table11.
Data are derived from the 2000 US Census long form and include demographic characteristics (age, race, sex), housing characteristics (housing structure, number of rooms, telephone surface), economic characteristics (occupation, place of work and journey to work) and financial characteristics (value of home, rent, utilities cost) for each census tract.
We also used data from the 2004 Consumer Expenditure database which outlines the locality of food stores using a multi-level hierarchical classification system. The data are derived from an extensive modeling effort using the 1994, 1995, 1996, 1997, and 2000 Consumer Expenditure Survey data from the Bureau of Labor Statistics (BLS), in addition to the latest 1998 overview data. The BLS survey averages over 5,000 households four times a year using a rotating sampling frame. We used aggregate data at the census tract level (estimated at 3000-5000 persons).
Participants in the Look AHEAD study underwent extensive data collection at baseline, including interview, physical examination, and blood and urine assays. Although the trial will last over 10 years, this manuscript is restricted to data collected at baseline only. The parent study was approved by the Johns Hopkins Western Institutional Review Board and all participants signed written informed consent to participate in the study.
Using the Census data, indices of neighborhood socio-economic status developed by Diez-Roux and Winkleby/Cubbin, were created using variables such as the % of persons living below poverty, % of adults with a college degree, median household income, % of persons earning interest income, % of adults in executive/managerial occupations, and % of adults who are unemployed. After considering these measures used in previous studies [29-31], we ultimately decided on the single item "% of individuals in the census tract living below the federal poverty line" because this measure is highly correlated with other census-based indices and has been shown to be similarly predictive of health outcomes .
Data on food availability in the census tract was categorized using the North American Industry Classification System (NAICS) definitions into: 1) food stores these establishments retail food and beverages merchandise from fixed point-of-sale locations. Establishments in this subsector have special equipment (e.g., freezers, refrigerated display cases, refrigerators) for displaying food and beverage goods. They have staff trained in the processing of food products to guarantee the proper storage and sanitary conditions required by regulatory authority; includes grocery stores and supermarkets; 2) convenience stores these establishments primarily engaged in retailing a limited line of goods that generally includes milk, bread, soda, and snacks; and 3) restaurants these establishments primarily engaged in providing food services to patrons who order and are served while seated (i.e. waiter/waitress service and pay after eating. they may provide this type of food service to patrons in combination with selling alcoholic beverages, providing carry out services, or presenting live non-theatrical entertainment; includes full-service, fast food, and carryout.
Dependent variables included eating patterns, weight loss control practices, and BMI. Variables capturing participant eating patterns consisted of reports of eating breakfast, lunch, and dinner and whether they ate at fast-food or non-fast food restaurants. Dietary intake, daily total fat, saturated fat, and fruit and vegetable intake was measured on a sub-set of individuals at baseline (629 participants in the ancillary study). Questions related to attempting weight loss and participating in weight loss programs and weight loss control practices related to food, physical activity, and weight control resource use were also examined. Examples of resources use include purchases of exercise equipment or weight loss program membership. For multivariate analysis purposes, individual questions were summarized to create separate scores for resource use related to physical activity, weight control, and food preparation. BMI was calculated using measured height and weight.
In this analysis, the main independent variables were the neighborhood factors and the main dependent variables were individual-level weight-related variables from the Look AHEAD study. Descriptive statistics were used to describe the study population.
Multi-level analyses were used to analyze the aggregate and individual level data [32-34]. Recognizing that when studying group-level variables, individuals are nested within those groups, multi-level analyses are designed to account for this clustering. Specifically, the model building first identifies the most predictive set of individual-level variables. Then aggregate-level variables are added. At each level, all variables and their interaction effects are tested. Random effects terms are then added as additional parameters to account for extra area-level variability not explained by the model and included variables (overdispersion) .
In the current study, the association between neighborhood factors (% poverty, food availability for the census tract) and individual-level weight-related outcomes were determined while accounting for individual level SES (personal income and education). This enabled us to determine the independent effects of the neighborhood SES. Other potential confounders included in the models were: age, sex, and race. All analyses were conducted using STATA statistical software, version 9.
Selected baseline characteristics of the study participants are presented in Table Table1.1. Participants were on average 59.5 ± 6.7 years of age, 41% male, and 27% were Black/African American. About half of participants had at least some college education; the majority of participants had annual incomes > $40,000. All participants were at least overweight or obese (BMI > 25 kg/m2),eligibility criteria for Look AHEAD.
Participant neighborhoods were diverse. Of all the neighborhoods represented in the study, the mean % of those living below the federal poverty level was 11%. Neighborhoods on average had 1.3 ± 1.5 food stores, 0.6 ± 0.8 convenience stores, and 6.8 ± 10.8 restaurants (fast food and non-fast food). Overall, there were 920 unique census tracts represented in the study; Baltimore = 201, New York= 257, Philadelphia = 245, Pittsburgh = 217. The number of participants per census tract ranged from 1-6.
With respect to dietary intake and eating patterns, most participants did not meet the recommended intakes for total fat, saturated fat, and fruit and vegetables. Most participants reported eating breakfast, lunch and dinner every day, and about a quarter reported eating those meals at a fast food restaurant more than once a week.
The vast majority of participants reported that they were currently attempting weight loss (96%) and 62% reported that they had participated in a weight loss program before the study. Many reported various weight control strategies such as cutting out sweets and junk food from their diets (63%), increasing fruit and vegetables (65%), and increasing exercise levels (55.3). With respect to resources spent on food, physical activity, and weight control, the most common were purchase of food preparation equipment (51%), indoor exercise equipment (33.8%), and class membership services for weight loss (33%).
Table Table22 outlines the association between neighborhood and eating patterns. Participants living in neighborhoods with more restaurantswere significantly more likely to eat breakfast and lunch at restaurants that were not fast food restaurants compared to those living in neighborhoods with fewer restaurants. Furthermore, they were significantly more likely to eat dinner 7 days per week.
Neighborhood SES had little association with weight control practices (see Table Table3).3). Those who lived in neighborhoods with more restaurants were less likely to be attempting weight loss, and more likely to participate in weight loss control practices related to food and physical activity than those who lived in neighborhoods with fewer restaurants. There was no significant association seen for neighborhood and BMI.
Those living in neighborhoods with more poverty were significantly more likely to have purchased food preparation equipment in the past year compared to those living in neighborhoods with the least poverty (PR = 1.36, see Table Table44).
Contrary to our hypothesis, those who lived in poorer neighborhoods had lower intakes of total and saturated fat compared to those living in wealthier neighborhoods (Table (Table5).5). This did not appear to be influenced by total caloric intake.
Our results suggest that among this group of overweight adults with type 2 diabetes in the Look AHEAD study that: 1) the presence of more restaurants in the neighborhood was associated with eating at non-fast food restaurants and with participation in several food and physical activity weight control practices; 2) neighborhood SES was only associated with a few of the weight-related factors. These conclusions are supported by a study with a diverse range of neighborhoods, detailed individual-level data, and a large percentage of minority participants.
Studies of neighborhood and health have generally focused on the physical built environment and its relation to physical activity[35-41]. Some studies have evaluated neighborhood and dietary patterns[42-44], and more recent studies have evaluated obesity or weight status as an outcome [45-50]. Few studies, to date, have evaluated neighborhood SES or other characteristics with weight control practices. Our study, which was conducted within a large-scale weight loss trial, had the strength of including a wealth of individual-level data on eating patterns, weight control practices, along with resource use for weight loss purposes.
There were, however, a few limitations. First, using the census tract as a proxy for neighborhood has been criticized, however, many studies have used this indicator, allowing us to compare our findings across studies. Furthermore, the wealth of data available from the US Census provides a comprehensive view of this geographic entity. Similarly, the neighborhood data may not have represented the entire baseline time-period for the Look AHEAD study. Data used were from the 2000 Census and 2004 Consumer database; Look AHEAD participants were recruited from 2001-2004. Neighborhoods are constantly changing, however the time-frame for the data used was close to the study recruitment period. Second, given the eligibility criteria for entry into the study, the population was fairly homogeneous with respect to some factors. One example was weight, which may explain why there was little variation of BMI status by neighborhood. This may explain many of our negative findings. In a future study, we plan to conduct longitudinal analyses and determine how neighborhood influences response to the weight loss intervention. The longitudinal analyses should show more variation in the dependent variables as individuals respond differently to the intervention. Furthermore, as this was an exploratory study, there were many negative findings that may have been due to low statistical power.
Future studies should evaluate neighborhood in relation to weight loss behaviors in other populations and further explore the impact of various aspects of the physical and social neighborhood environment. Now that individual-level correlates of healthy weight and weight loss are fairly well understood, attention should be given to other social and environmental determinants that may have a substantial impact. In addition to policy changes such as those that regulate the unhealthy selections in restaurants on an environmental level, incorporating teaching points on influences such as portion control and choosing health options in restaurants should contribute to more successful weight-loss interventions.
The authors declare that they have no competing interests.
TLG and FLB were responsible for the conception and design of the study. KB was responsible for the data management and data analysis. LP advised on the statistical analysis. TLG drafted the manuscript. KB, JW, JP, XFP, AFB, LJ, FLB were responsible for critical review of the manuscript and interpretation of findings. All authors have read and approved the final manuscript.
The pre-publication history for this paper can be accessed here:
The authors would like to acknowledge the Look AHEAD staff and participants who made this research possible.
This project was funded by grants from the National Institutes of Health.
Dr. Gary-Webb was funded by grants from the NIDDK (U01-DK57149-05S1) and NHLBI (K01-HL084700) and Dr. Brancati was funded by a grant from the NIDDK (K24-DK6222). The authors would like to acknowledge the Look AHEAD research group, which has been previously described (ref 26).
Look AHEAD Research Group at Baseline
The Johns Hopkins Medical Institutions Frederick Brancati, MD, MHS; Debi Celnik, MS, RD, LD; Jeff Honas, MS; Jeanne Clark, MD, MPH; Jeanne Charleston, RN; Lawrence Cheskin, MD; Kerry Stewart, EdD; Richard Rubin, PhD; Kathy Horak, RD
Pennington Biomedical Research Center George A. Bray, MD; Kristi Rau; Allison Strate, RN; Frank L. Greenway, MD; Donna H. Ryan, MD; Donald Williamson, PhD; Elizabeth Tucker; Brandi Armand, LPN; Mandy Shipp, RD; Kim Landry; Jennifer Perault
The University of Alabama at Birmingham Cora E. Lewis, MD, MSPH; Sheikilya Thomas MPH; Vicki DiLillo, PhD; Monika Safford, MD; Stephen Glasser, MD; Clara Smith, MPH; Cathy Roche, RN; Charlotte Bragg, MS, RD, LD; Nita Webb, MA; Staci Gilbert, MPH; Amy Dobelstein; L. Christie Oden; Trena Johnsey
Massachusetts General Hospital: David M. Nathan, MD; Heather Turgeon, RN; Kristina P. Schumann, BA; Enrico Cagliero, MD; Kathryn Hayward, MD; Linda Delahanty, MS, RD; Barbara Steiner, EdM; Valerie Goldman, MS, RD; Ellen Anderson, MS, RD; Laurie Bissett, MS, RD; Alan McNamara, BS; Richard Ginsburg, PhD; Virginia Harlan, MSW; Theresa Michel, MS
Joslin Diabetes Center: Edward S. Horton, MD; Sharon D. Jackson, MS, RD, CDE; Osama Hamdy, MD, PhD; A. Enrique Caballero, MD; Sarah Ledbury, MEd, RD; Maureen Malloy, BS; Ann Goebel-Fabbri, PhD; Kerry Ovalle, MS, RCEP, CDE; Sarah Bain, BS; Elizabeth Bovaird, BSN,RN; Lori Lambert, MS, RD
Beth Israel Deaconess Medical Center: George Blackburn, MD, PhD; Christos Mantzoros, MD, DSc; Ann McNamara, RN; Heather McCormick, RD
University of Colorado Health Sciences Center James O. Hill, PhD; Marsha Miller, MS, RD; Brent VanDorsten, PhD; Judith Regensteiner, PhD; Robert Schwartz, MD; Richard Hamman, MD, DrPH; Michael McDermott, MD; JoAnn Phillipp, MS; Patrick Reddin, BA; Kristin Wallace, MPH; Paulette Cohrs, RN, BSN; April Hamilton, BS; Salma Benchekroun, BS; Susan Green; Loretta Rome, TRS; Lindsey Munkwitz, BS
Baylor College of Medicine John P. Foreyt, PhD; Rebecca S. Reeves, DrPH, RD; Henry Pownall, PhD; Peter Jones, MD; Ashok Balasubramanyam, MD; Molly Gee, MEd, RD
University of California at Los Angeles School of Medicine Mohammed F. Saad, MD; Ken C. Chiu, MD; Siran Ghazarian, MD; Kati Szamos, RD; Magpuri Perpetua, RD; Michelle Chan, BS; Medhat Botrous
The University of Tennessee Health Science Center
University of Tennessee East. Karen C. Johnson, MD, MPH; Leeann Carmichael, RN; Lynne Lichtermann, RN, BSN
University of Tennessee Downtown. Abbas E. Kitabchi, PhD, MD; Jackie Day, RN; Helen Lambeth, RN, BSN; Debra Force, MS, RD, LDN; Debra Clark, LPN; Andrea Crisler, MT, Donna Green, RN; Gracie Cunningham; Maria Sun, MS, RD, LDN; Robert Kores, PhD; Renate Rosenthal, PhD; and Judith Soberman, MD
University of Minnesota Robert W. Jeffery, PhD; Carolyn Thorson, CCRP; John P. Bantle, MD; J. Bruce Redmon, MD; Richard S. Crow, MD; Jeanne Carls, MEd; Carolyne Campbell; La Donna James; T. Ockenden, RN; Kerrin Brelje, MPH, RD; M. Patricia Snyder, MA, RD; Amy Keranen, MS; Cara Walcheck, BS, RD; Emily Finch, MA; Birgitta I. Rice, MS, RPh, CHES; Vicki A. Maddy, BS, RD; Tricia Skarphol, BS
St. Luke's Roosevelt Hospital Center Xavier Pi-Sunyer, MD; Jennifer Patricio, MS; Jennifer Mayer, MS; Stanley Heshka, PhD; Carmen Pal, MD; Mary Anne Holowaty, MS, CN; Diane Hirsch, RNC, MS, CDE
University of Pennsylvania Thomas A. Wadden, PhD; Barbara J. Maschak-Carey, MSN, CDE; Gary D. Foster, PhD; Robert I. Berkowitz, MD; Stanley Schwartz, MD; Shiriki K. Kumanyika, PhD, RD, MPH; Monica Mullen, MS, RD; Louise Hesson, MSN; Patricia Lipschutz, MSN; Anthony Fabricatore, PhD; Canice Crerand, PhD; Robert Kuehnel, PhD; Ray Carvajal, MS; Renee Davenport; Helen Chomentowski
University of Pittsburgh David E. Kelley, MD; Jacqueline Wesche -Thobaben, RN,BSN,CDE; Lewis Kuller, MD, DrPH.; Andrea Kriska, PhD; Daniel Edmundowicz, MD; Mary L. Klem, PhD, MLIS; Janet Bonk, RN, MPH; Jennifer Rush, MPH; Rebecca Danchenko, BS; Barb Elnyczky, MA; Karen Vujevich, RN-BC, MSN, CRNP; Janet Krulia, RN ,BSN ,CDE; Donna Wolf, MS; Juliet Mancino, MS, RD, CDE, LDN; Pat Harper, MS, RD, LDN; Anne Mathews, MS, RD, LDN
Brown University Rena R. Wing, PhD; Vincent Pera, MD; John Jakicic, PhD; Deborah Tate, PhD; Amy Gorin, PhD; Renee Bright, MS; Pamela Coward, MS, RD; Natalie Robinson, MS, RD; Tammy Monk, MS; Kara Gallagher, PhD; Anna Bertorelli, MBA, RD; Maureen Daly, RN; Tatum Charron, BS; Rob Nicholson, PhD; Erin Patterson, BS; Julie Currin, MD; Linda Foss, MPH; Deborah Robles; Barbara Bancroft, RN, MS; Jennifer Gauvin, BS; Deborah Maier, MS; Caitlin Egan, MS; Suzanne Phelan, PhD; Hollie Raynor, PhD, RD; Don Kieffer, PhD; Douglas Raynor, PhD; Lauren Lessard, BS; Kimberley Chula-Maguire, MS; Erica Ferguson, BS, RD; Richard Carey, BS; Jane Tavares, BS; Heather Chenot, MS; JP Massaro, BS
The University of Texas Health Science Center at San Antonio Steve Haffner, MD; Maria Montez, RN, MSHP, CDE; Connie Mobley, PhD, RD; Carlos Lorenzo, MD
University of Washington/VA Puget Sound Health Care System Steven E. Kahn, MB, ChB; Brenda Montgomery, MS, RN, CDE; Robert H. Knopp, MD; Edward W. Lipkin, MD, PhD; Matthew L. Maciejewski, PhD; Dace L. Trence, MD; Roque M. Murillo, BS; S. Terry Barrett, BS
Southwestern American Indian Center, Phoenix, Arizona and Shiprock, New Mexico William C. Knowler, MD, DrPH; Paula Bolin, RN, MC; Tina Killean, BS; Carol Percy, RN; Rita Donaldson, BSN; Bernadette Todacheenie, EdD; Justin Glass, MD; Sarah Michaels, MD; Jonathan Krakoff, MD; Jeffrey Curtis, MD, MPH; Peter H. Bennett, MB, FRCP; Tina Morgan; Ruby Johnson; Cathy Manus; Janelia Smiley; Sandra Sangster; Shandiin Begay, MPH; Minnie Roanhorse; Didas Fallis, RN; Nancy Scurlock, MSN, ANP; Leigh Shovestull, RD
Wake Forest University School of Medicine Mark A. Espeland, PhD; Judy Bahnson, BA; Lynne Wagenknecht, DrPH; David Reboussin, PhD; W. Jack Rejeski, PhD; Wei Lang, PhD; Alain Bertoni, MD, MPH; Mara Vitolins, DrPH; Gary Miller, PhD; Paul Ribisl, PhD; Kathy Dotson, BA; Amelia Hodges, BS; Patricia Hogan, MS; Kathy Lane, BS; Carrie Combs, BS; Christian Speas, BS; Delia S. West, PhD; William Herman, MD, MPH
Central Resources Centers
DXA Reading Center, University of California at San Francisco Michael Nevitt, PhD; Ann Schwartz, PhD; John Shepherd, PhD; Jason Maeda, MPH; Cynthia Hayashi; Michaela Rahorst; Lisa Palermo, MS, MA
Central Laboratory, Northwest Lipid Research Laboratories Santica M. Marcovina, PhD, ScD; Greg Strylewicz, MS
ECG Reading Center, EPICARE, Wake Forest University School of Medicine
Ronald J. Prineas, MD, PhD; Zhu-Ming Zhang, MD; Charles Campbell, AAS, BS; Sharon Hall
Diet Assessment Center, University of South Carolina, Arnold School of Public Health, Center for Research in Nutrition and Health Disparities Elizabeth J Mayer-Davis, PhD; Cecilia Farach, DrPH
National Institute of Diabetes and Digestive and Kidney Diseases: Barbara Harrison, MS; Susan Z.Yanovski, MD; Van S. Hubbard, MD PhD
National Heart, Lung, and Blood Institute: Lawton S. Cooper, MD, MPH; Eva Obarzanek, PhD, MPH, RD; Denise Simons-Morton, MD, PhD
Centers for Disease Control and Prevention: David F. Williamson, PhD; Edward W. Gregg, PhD
Funding and Support
This study is supported by the Department of Health and Human Services through the following cooperative agreements from the National Institutes of Health: DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, and DK56992. The following federal agencies have contributed support: National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Nursing Research; National Center on Minority Health and Health Disparities; Office of Research on Women's Health; and the Centers for Disease Control and Prevention. This research was supported in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. The Indian Health Service (I.H.S.) provided personnel, medical oversight, and use of facilities. The opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the I.H.S. or other funding sources.
Additional support was received from The Johns Hopkins Medical Institutions Bayview General Clinical Research Center (M01-RR-02719); the Massachusetts General Hospital Mallinckrodt General Clinical Research Center (M01-RR-01066); the University of Colorado Health Sciences Center General Clinical Research Center (M01 RR00051) and Clinical Nutrition Research Unit (P30 DK48520); the University of Tennessee at Memphis General Clinical Research Center (M01RR00211-40); the University of Pittsburgh General Clinical Research Center (M01 RR000056 44) and NIH grant (DK 046204); and the University of Washington/VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs.
The following organizations have committed to make major contributions to Look AHEAD: Federal Express; Health Management Resources; Johnson & Johnson, LifeScan Inc.; Optifast-Novartis Nutrition; Roche Pharmaceuticals; Ross Product Division of Abbott Laboratories; Slim-Fast Foods Company; and Unilever.