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Table 1

Promoter methylation and protein expression of FHIT gene and clinicopathologic factors in DTC

Methylation
Protein expression
Characteristicsn-+Positive rate (%)-+++Positive rate (%)
Gender
Male1916315.896452.6
Female46331328.32912537.0
Age
<453023723.31710343.3
>453526925.7218640.0
Classification
FTC2315834.8157134.8
PTC4234819.02311845.2
TNM stage
I ~ II4841714.6Δ2514947.9
III ~ IV178952.9134023.5
grade
I4336716.3*2015853.5Δ
II2213940.9183118.2
Lymph node metastasis
Yes26161038.5*224015.4Δ
No3933615.41614959.0

FTC: follicular thyroid carcinoma; PTC: papillary thyroid carcinoma

ΔP<0.01;
*P<0.05, as compared between groups of pathological grade, TNM stages or metastasis.