Summary of Differences in GABA-Related Transcript Expression in Subjects With Schizophrenia Across the Four Cortical Areasa
aDifferences in expression within each subject pair for each transcript are plotted as log2-transformed ratios of schizophrenia subjects to normal comparison subjects. Corresponding nontransformed schizophrenia/normal comparison expression ratios are shown on the right axis. Horizontal bars indicate the mean for all subject pairs in each cortical area.
bSignificant effect of diagnosis only for GAD67 (F=18, df=1, 6.5, p=0.005) and both diagnosis (F=11, df=1, 11, p=0.008) and area (F=20, df=3, 9.4, p<0.001) for GAD65.
cSignificant effect of both diagnosis (F=4.9, df=1, 11, p=0.048) and area (F=15, df=3, 11, p<0.001).
dSignificant effect of both diagnosis (F=21, df=1, 7.6, p=0.002) and area (F=870, df=3, 6.5, p<0.001).
eSignificant effect of both diagnosis (F=36, df=1, 9.1, p<0.001) and area (F=130, df=3, 6.5, p<0.001).
fSignificant effect of area only (F=150, df=3, 9, p<0.001).
gSignificant effect of both diagnosis and area for GABAA receptor α1 subunit (F=8.3, df=1, 9.2, p=0.018; F=220, df=3, 5.5, p<0.001, respectively) and δ subunit (F=14, df=1, 6.5, p=0.008; F=113, df=3, 7.6, p<0.001, respectively).