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Logo of brjgenpracThe British Journal of General Practice
Br J Gen Pract. 2010 July 1; 60(576): 521–523.
PMCID: PMC2894382

Protecting generalism: moving on from evidence-based medicine?

Joanne Reeve, BClinSci, PhD, MPH, MRCGP, DipFPH, NIHR Clinician Scientist in Primary Care


Quality of decision making in modern health care is defined with reference to evidence-based medicine. There are concerns that this approach is insufficient for, and may thus threaten the future of, generalist primary care. We urgently need to extend our account of quality of knowledge use and decision making in order to protect and develop the discipline. Interpretive medicine describes an alternative framework for use in generalist care. Priorities for clinical practice and research are identified.

Keywords: evidence-based medicine, generalism, quality

Evidence-based medicine (EBM) was first described as an approach to teaching the practice of medicine.1 Twenty-five years on, it has become an assumed standard of ‘best’2 or even ‘reasonable’3 practice. EBM recognised a need to support healthcare professionals in maintaining an up-to-date working account of the ever-expanding scientific knowledge about illness and health care. Defined as the ‘judicious application of best evidence in making clinical decisions about this individual’,4 EBM acknowledges both the value and necessity of external research evidence integrated with clinical expertise in clinical decision making.4,5 Good doctors use both; neither alone is enough.4 EBM describes an ‘ideal of practice’6 and few GPs would reject a principle of evidence-informed decision making.3,7

It is in the detail and implementation of that ideal that problems have arisen. Sackett defined best evidence as that which was ‘clinically relevant’,4 but with heavy emphasis placed on the approaches of clinical epidemiology,4,5 and randomised trials of interventions.4 The evidence-based practice movement has embraced the philosophy of positivist science.6 ‘Hierarchies’ of evidence privilege knowledge from what some consider to be a narrow methodological perspective;3,6 an approach which is contested.6 As health policy identified evidence-based practice as a tool to address variation and quality in care, the ideals of EBM have developed into what Harrison describes as ‘scientific bureaucratic medicine’.8 With concerns that healthcare professionals are ‘too busy’ to practice EBM, external knowledge experts following defined rules for interpretation created definitive guidelines for clinical decision making.8 The disadvantages of constrained protocol-driven care are recognised by the profession;7 but still form a new formative normative framework for clinical practice.8,9 Problems with implementation shouldn't lead us to reject the concept of EBM, but do suggest the need for critical review and development.

EBM was developed within the disease-oriented setting of specialist secondary care. Yet generalist practice is more than disease-focused care delivered in a community setting. It is a different approach to understanding and addressing health and illness. Generalism describes a philosophy of practice which is person, not disease, centred; continuous, not episodic; integrates biotechnical and biographical perspectives; and views health as a resource for living and not an end in itself.1013 Stange has called for a revival of the generalist approach to address growing concerns about the inefficiency, ineffectiveness, and inequity of fragmented health care.14 He highlights the need to understand specific events in their broader context, integrating biomedical evidence with a reflexive and interpretative approach that acknowledges the complexity of individual human experience.11,12,14 With evidence that the current model of EBM as a normative model of practice may be contributing to a shift away from generalist principles to a more disease-focused model of care,10,14,15 we need an alternative approach to defining quality of knowledge use within generalist practice.

I have therefore described interpretive medicine as an alternative account of knowledge use in generalist practice. Interpretive medicine is the critical, thoughtful, professional use of an appropriate range of knowledge in the dynamic, shared exploration and interpretation of individual illness experience, in order to support the creative capacity of individuals in maintaining their daily lives.10 It describes a person-centred, rather than disease-centred, approach; emphasises interpretation and co-construction of knowledge over application; and privileges the outcome of knowledge use (in terms of its impact on self-agency) over the ‘correct’ identification of a disease status.

How this fits in

The principles of evidence-based medicine define quality decision making in specialist care. Generalist care lacks an equivalent framework adequate to define quality of person-centred decision making. This gap threatens the future of the discipline. Interpretive medicine describes an alternative framework for use in generalist care.

Interpretive medicine offers an account of knowledge use which is closer to the ‘usual care’7 of generalist practice. Working within the ‘swampy lowlands’16 of general practice invokes care that is characterised by complexity, uncertainty, and change.1719 Consider a typical patient seen in today's general practice: a woman in her 80s with chronic heart and lung disease; taking 15 medicines a day; with no family, living in residential care as a result of cognitive decline and social isolation; and who recently fell and fractured her hip. Chronic disease guidelines define ‘best’ care for the management of each of her disease-states, but in turn contribute to the 15 medicines a day. Polypharmacy was a likely contributory factor in her recent fall; her fractured neck of femur significantly increases her risk of death in the following year. No guidance describes when medications, especially those for primary prevention, should be withdrawn. There is no specific guidance for when clinicians could, or should, work ‘off protocol’ in the care of patients with complex needs.

In making clinical decisions about such a patient, EBM starts with a disease-focused principle of care often summarised in a guideline. It asks practitioners to justify why this patient should be excluded from evidence-based care. Interpretive medicine starts with a principle that health care should support, and certainly not hinder, individuals in their ongoing efforts to live their lives. It asks practitioners to justify why this protocol could be used for this patient. Both approaches need a sound understanding of current scientific knowledge; interpretive medicine is not an excuse for ignorance. But the distinction reveals an important difference in emphasis, with a different approach to the application of knowledge in supporting health care. Practising clinicians, and indeed many patients and carers, will recognise these issues as part of the daily complex decision making of generalist practice. However, this complex and skilled task is undersupported and undervalued within increasingly specialist and fragmented models of illness and care.

Interpretive medicine represents an important shift in emphasis from the application of evidence in decision making, to the generation of individualised knowledge as an essential quality marker of generalist care. An extensive body of professional writing addresses the skills and processes needed for individualised care: in applying clinical judgement to address the limitations of knowledge; in dealing with the epistemological uncertainty that comes in seeking to apply ‘certain’ knowledge derived from the study of disease in populations to understand an individual patient;20 and in integrating biological and biographical accounts of illness.12 The field of narrative medicine provides one such account of how to undertake person-centred practice.21,22 Even with this rich heritage, we must not be complacent about the ongoing need for education and training to support the development and maintenance of skills of interpretive medicine.23 However, my concern within this paper is to highlight the need to now focus on evaluation of the quality and outcomes of generalist care. We need a framework to describe quality of knowledge generation and use in interpretive care, and hence the implications for patient outcomes.

Interpretive medicine describes a process of knowledge generation: knowledge which may be subjected to similar tests of trustworthiness as that generated by research. Drawing on Doucet and Mauthner's24 assertion that knowledge should be judged by reviewing the processes and assumptions by which it is produced, rather than solely by its proximity to truth, I propose two urgent priorities for clinicians and academics in developing interpretive medicine as a framework to support generalist practice.

First, we need a tool to support front-line practitioners in maintaining skills and confidence in the interpretive process. I propose the development of a knowledge appraisal tool to support evaluation of the processes and outcomes of knowledge generation within the context of a person-centred consultation.10 The tool should support practitioners in considering what data is collected (a patient narrative, practitioner narrative, and clinical signs). It should promote reflection on the interpretive stance of both patient and doctor (understanding illness from a biomedical and/or biographical perspective). Reflection should lead to a critical analysis of alternative interpretations, opportunities missed, and the potential impact on outcomes. An interesting development could include reflection with the patient, possibly with an appraiser as facilitator. Criteria for quality, similar to those described for qualitative research,25 provide a tool to support external review of the interpretive process10 and thus address concerns about unsupported, and undervalued, interpretive practice.

Second, we need research into the patient outcomes resulting from different approaches to knowledge use, and particularly an interpretive approach in the care of patients with complex needs. Through consultation analysis, we need to be able to identify interpretive (generalist) and non-generalist approaches to care so that we can evaluate the impact of each approach on individual patient outcomes. We need to understand when an interpretive approach is of value, and when more disease-focused (protocol-informed) care is useful for this individual. Key questions include who needs generalist (beyond protocol) care, when, and with what outcomes? Answers to these are fundamental to planning the future delivery of care.

The legitimate use of knowledge is a defining aspect of modern clinical practice,10 and shapes ideas about quality in practice. The ability to integrate knowledge to provide individualised care should be seen as a marker of quality in generalist practice.10 The profession should be judged not purely by what knowledge it uses, but by the way it uses it. We therefore need to shift the gaze from easier to measure but limited accounts of practice based on the application of certain knowledge to a more appropriate assessment of knowledge use, in order to strengthen and preserve core elements of the discipline and promote and support the health needs of the public.


The authors wishes to give thanks to Chris Dowrick and to the journal peer reviewers for helpful comments on an earlier draft.



At the time of writing, Joanne was employed as an NIHR Clinical Lecturer in Primary Care at the University of Manchester.

Competing interests

The authors have stated that there are none.

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By the same author

Occasional Paper 88 — Interpretive medicine: Supporting generalism in a changing primary care world. Dr Joanne Reeve, RCGP: 2010

This Occasional Paper looks at current models of knowledge use in general practice. It contains a critical review of the literature, and draws on the author's empirical research and reflections from clinical practice. It is available for purchase via the RCGP Online Bookstore:, priced £15.00 (RCGP members: £13.50).


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