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Logo of kjrManuscript SubmissionAbout UsInstructions for AuthorsKorean Journal of RadiologyThis Article
Korean J Radiol. 2010 Jul-Aug; 11(4): 457–468.
Published online 2010 June 21. doi:  10.3348/kjr.2010.11.4.457
PMCID: PMC2893317

Cystic Lesions of the Gastrointestinal Tract: Multimodality Imaging with Pathologic Correlations


The cystic lesions of the gastrointestinal (GI) tract demonstrate the various pathologic findings. Some lesions may present a diagnostic challenge because of non-specific imaging features; however, other lesions are easily diagnosed using characteristic radiologic features and anatomic locations. Cystic masses from the GI tract can be divided into several categories: congenital lesions, neoplastic lesions (cystic neoplasms, cystic degeneration of solid neoplasms), and other miscellaneous lesions. In this pictorial review, we describe the pathologic findings of various cystic lesions of the GI tract as well as the radiologic features of GI cystic lesions from several imaging modalities including a barium study, transabdominal ultrasound (US), computed tomography (CT), and magnetic resonance (MR) imaging.

Keywords: Cystic lesions, Gastrointestinal tract, Barium study, Ultrasound (US), Computed tomography (CT), Magnetic resonance (MR)

Cystic lesions of the gastrointestinal (GI) tract rarely occur and often demonstrate various pathologic findings. These lesions can be divided into several categories: congenital lesions, neoplastic lesions, and miscellaneous lesions (Table 1). Most of the cystic masses of the GI tract are discovered incidentally and usually appear as submucosal lesions. Patients can present with a variety of symptoms, including abdominal pain, bowel obstruction, perforation, intussusception, intestinal bleeding, and associated malignancy. Histologically, most of the cystic lesions of the GI tract are benign; however, some represent cystic changes in malignant tumors or potentially malignant. A number of imaging modalities, such as plain abdominal radiograph, barium study, transabdominal ultrasonography (US), computed tomography (CT), and magnetic resonance (MR) imaging, have been used to differentiate among cystic lesions. Although the roles of radiologic imaging modalities are limited due to a substantial overlap in radiologic findings, some cystic lesions have predominant or specific radiologic features. When these features are coupled with the anatomic location of a lesion, a correct diagnosis can often be inferred.

Table 1
Classification of Cystic Lesions of Gastrointestinal Tract

Herein, we describe and illustrate the multimodality imaging features of cystic lesions of the GI tract, and correlate these features with pathologic findings in order to suggest a specific diagnosis or to substantially narrow the differential diagnosis using the imaging appearance and anatomic location of the lesion.


Duplication Cyst

Duplication cysts of the GI tract are rare congenital anomalies that most commonly affects the ileum, followed by the esophagus, large bowel, and jejunum (1, 2). Duplication cysts of the stomach (Fig. 1) and duodenum (Fig. 2) are uncommon, comprising only 5-7% of all intestinal duplications (1). The three diagnostic criteria for duplication cysts include the presence of an intimate attachment to the GI tract, a layer of smooth muscle in the wall, and an epithelial lining resembling some part of the GI tract (1). The cysts become incorporated into the bowel wall and share a common blood supply with the parent bowel. Duplication cysts may also contain heterotopic tissues, including gastric mucosa, pancreas (Fig. 1), lymphoid tissue, and respiratory epithelium (1, 3). The clinical manifestations of duplication cysts depend on the location, size, and mucosal pattern. GI bleeding or perforation is especially likely if duplications contain ectopic gastric mucosa, which occurs in 20-50% of duplications or ectopic pancreatic tissue (1, 2).

Fig. 1
Gastric duplication cyst in 29-year-old man.
Fig. 2
Duodenal duplication cyst in 9-year-old boy.

A plain abdominal radiograph may help detect a soft tissue mass, or sometimes a curvilinear calcification of the cystic wall (1). A barium study would divulge a polypoid submucosal mass (Fig. 1) or indentation of the GI tract by an extrinsic mass. If the duplications communicate with the lumen, the spherical or tubular structures filled with barium would appear to be adjacent to the GI tract. The diagnosis of duplications is easy achieved when the typical sonographic findings with an inner echogenic mucosa and an outer hypoechoic muscle layer are demonstrated within the cyst on transabdominal US (4). If duplication cysts become infected or hemorrhage occurs in the cyst, echogenic debris may be detected (Fig. 2). The CT findings of duplications usually include a large, well-circumscribed, spherical (Fig. 1), or tubular (Fig. 2) cystic mass. Rarely, duplication cysts co-exist with wall calcifications or enterocoliths. On MR imaging, duplications are seen as well-circumscribed, homogeneous, hypointense masses on a T1-weighted image with a high signal intensity, accompanied by various internal signals due to associated hemorrhage or mucous secretion on a T2-weighted image (Fig. 2). The thin cyst wall shows slight enhancement with contrast.

Heterotopic Pancreas

A heterotopic pancreas is characterized by the presence of normally developed pancreatic tissue outside its usual anatomic location without any anatomic or vascular continuity. A heterotopic pancreas occurs throughout the GI tract, most commonly in the stomach, followed by the duodenum and jejunum (5). In the stomach, a heterotopic pancreas tends to be located along the greater curvature of the gastric antrum within 6 cm of the pyloric canal; whereas, in the duodenum, it tends to be located in the proximal duodenum between the duodenal bulb and the ampulla of Vater (6, 7). Histologically, a heterotopic pancreas is composed of all of the pancreatic elements, including acini, islets of Langerhans, and ductal structures (Fig. 3), and is usually located in the submucosa. Cyst formation in a heterotopic pancreas is caused by secondary changes in the pancreatic tissue, including pseudocyst formation or cystic dystrophy (8). A heterotopic pancreas may result in epigastric pain or upper GI bleeding from irritation or ulceration of the adjacent mucosa by pancreatic secretions.

Fig. 3
Heterotopic pancreas in 57-year-old man with cecal cancer.

A heterotopic pancreas, identified by a barium study, has been described as a solitary, sharply-defined submucosal nodule. In rare cases, a central umbilication may be visualized, resulting from the reflux of barium into the rudimentary duct of the heterotopic pancreas. The CT findings of a heterotopic pancreas cover a diverse spectrum, including a unilocular cystic lesion (Fig. 3), multiple cysts, and a solid mass with contrast enhancement (5, 7, 9). On CT, a heterotopic pancreas shows a well-defined, oval, submucosal mass with smooth margins. Small hypodense areas may exist within the lesions, suggesting dilated ducts within the heterotopic pancreas. MR images show cystic lesions in a thickened wall of the GI tract (8).


Appendix Mucocele

Appendix mucoceles are dilatations of the appendix caused by an abnormal accumulation of mucus within the lumen have been identified in only 0.2-0.3% of appendectomy specimens on pathologic evaluation (10). The gross appearance of an appendix mucocele on pathologic evaluation is one of a tubular or spherical mucus-filled mass (Fig. 4), which is divided into four categories according to the features of the epithelium: retention mucocele, mucinous cystadenoma, mucinous adenocarcinoma, and mucinous tumors of uncertain malignant potential. Retention mucoceles are usually unilocular and lined by flattened, atrophic epithelium. Mucinous cystadenomas are circumferentially lined by neoplastic mucinous epithelium that replaces the normal epithelium (Fig. 4). Clinical manifestations of mucinous cystadenomas include a palpable abdominal mass, right lower abdominal pain, intussusception, gastrointestinal bleeding, right ureteral obstruction, and increasing abdominal girth of pseudomyxoma peritonei, which is characterized by the intraperitoneal accumulation of mucin (11, 12).

Fig. 4
Mucinous cystadenoma of appendix in 67-year-old man.

A plain abdominal radiograph may show a soft-tissue mass in the right lower quadrant of the abdomen. In addition, the presence of a curvilinear wall calcification strongly supports the diagnosis of an appendix mucocele (Fig. 4). However, this finding is only seen in < 50% of cases (11). Transabdominal US usually reveals a unilocular, ovoid, anechoic mass in the region of the appendix (Fig. 4). The intraluminal echogenicity can be variable, including numerous, fine echo spots or soft echogenic masses according to acoustic interfaces produced by the mucin (13). When a mural calcification is present, sonography shows a highly echogenic wall with posterior shadowing (Fig. 4). CT can effectively demonstrate the anatomic relationship between the cystic mass and the cecum and the typical CT findings of an appendix mucocele are a round or tubular cystic mass with thin and enhancing walls in the appendiceal region (Fig. 4). Dystrophic calcification may be present in the wall of the mucocele (Fig. 4). On CT, pseudomyxoma peritonei appears as a low-attenuation substance in the abdomen, simulating ascites. MR imaging of an appendix mucocele reveals the cystic nature of the lesion, whereas a mural calcification is less apparent on MR imaging (12).


Lymphangiomas are uncommon benign tumors of the GI tract consisting of several expanded lymphatics in the submucosal layer. They are thought to arise from sequestered lymphatic tissue that fails to communicate with the normal lymphatic system. In general, lymphangiomas are solitary lesions; however, they can be present in multiples. GI lymphangiomas occur most frequently in the colon, followed by the duodenum and stomach (11). Grossly, lymphangiomas appear as round or oval translucent lesions covered by smooth mucosa. The cut surface of the lesion reveals a multicystic appearance that exudes a clear yellow or milky fluid (Fig. 5). Histologically, lymphangiomas are characterized by a localized proliferation of dilated lymphatic channels lined by benign-appearing endothelial cells (Fig. 5). Occasionally, lymphangiomas are large enough to cause obstructive symptoms or intussusception (11, 14). On endoscopy, GI lymphangiomas appear as soft, blue-tinged, submucosal masses (Fig. 5) with distended mucosal vessels. The shape of the mass is easily altered when pressure is applied.

Fig. 5
Cystic lymphangioma in colon of 57-year-old man.

A barium study demonstrates sharply demarcated submucosal masses that are indistinguishable from other mesenchymal tumors (Fig. 5). Because of their cystic nature, these lesions may be pliable on fluoroscopy and the shape may easily change in response to peristaltic movement and manual compression (15). On CT, GI lymphangiomas appear as round submucosal masses with homogeneous low attenuation and a well-demarcated, smooth margin (Fig. 5). The lesion may be unilocular or multicystic. A CT scan may show multiple sporadic calcifications when multiple lymphangiomas are present (14).


Occasionally, some types of solid neoplasms (i.e., gastrointestinal stromal tumors, neurogenic tumors, and adenocarcinomas) of the GI tract appear to be cystic. Cystic changes in a solid tumor can result from central necrosis of a large mass due to an inadequate blood supply. Other suggested mechanisms of cyst formation include liquefaction of an intratumoral hemorrhage or a treatment effect of chemotherapy.

It is difficult to radiologically discriminate between complex cystic lesions and cystic changes of solid tumors of the GI tract. Some radiologic features are more favorable for the cystic degeneration of solid tumors, such as thick, irregular walls, multiple thick septa within the cyst, and the presence of a distinct solid component in a cystic lesion. Cystic degeneration of solid tumors must be differentiated from other benign cystic lesions because malignant tumors can also undergo cystic degeneration.

Gastrointestinal Stromal Tumor

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the GI tract. They are most frequently found in the stomach, followed by the small bowel, duodenum, colon, rectum, and esophagus (11). GISTs are now thought to arise from the interstitial cells of Cajal and can be identified using immunohistochemistry to determine the expression of KIT (CD117), a cell membrane receptor with tyrosine kinase activity (16). Grossly, GISTs appear as well-circumscribed, lobulated, fleshy masses. GISTs can potentially demonstrate heterogeneous appearances due to areas of hemorrhage, necrosis, and cystic degeneration in the cut section. Histologic features of GISTs can be classified into three patterns: predominant presence of spindle cells (most common) (Fig. 6), predominant presence of epithelioid cells, or an admixture of spindle and epithelioid elements (16). Immunohistochemically, most tumors are positive for CD117. The most widely accepted criteria for evaluating the biologic behavior of GISTs (very low, low, intermediate, or high risk) are based on the combination of tumor size and mitotic activity. If the tumor is > 5 cm and the mitotic activity is > 5 mitoses for every 50 high-power fields, the lesion can be classified as demonstrating a high risk of aggressive behavior (16).

Fig. 6
Gastric gastrointestinal stromal tumor with cystic changes in 58-year-old woman.

The radiologic features of GISTs can vary depending on the size and level of aggressive behavior of the tumor. GISTs can appear as round, well-defined, homogeneous submucosal masses with contrast enhancement on CT and MRI if necrosis, hemorrhage, and cystic degeneration are not present. Some GISTs can show a cystic appearance resulting from central hemorrhage and necrosis. Cystic change is detected even when the tumor is small (Fig. 6). GISTs rarely manifest as a multilocular cystic mass (Fig. 7). A CT scan reveals a unilocular or multilocular thick-walled cystic mass with a peripheral enhancement pattern adjacent to the GI tract (Fig. 7). The low attenuation in the center of these lesions corresponds to hemorrhage or necrosis. MR imaging features of GISTs vary depending on the degree of necrosis and hemorrhage. Solid tumor portions yield low signal intensity on T1-weighted images, high signal intensity on T2-weighted images, and enhancement after gadolinium administration upon dynamic examination. Areas of hemorrhage within the tumor vary from a high-to-low signal intensity on both T1- and T2-weighted images (17).

Fig. 7
Gastric gastrointestinal stromal tumor with hemorrhage in 71-year-old man.


Gastrantestinal schwannomas, or neurilemmomas, account for 2-6% of all GI mesenchymal tumors (11). GI schwannomas arise from the myenteric plexus and are located in the submucosa and muscularis propria of the digestive tract wall. GI schwannomas have a predilection for the stomach (60-70% of cases), followed by the colon and rectum (18, 19). On gross evaluation, GI schwannomas appear to be well-encapsulated; however, histologically, GI schwannomas interdigitate with the surrounding stroma as S100-positive spindle cells admixed with a loose myxoid stroma (Fig. 8). The tumor cells may also form compact fascicles with weak nuclear palisading. GI schwannomas have some distinctive histologic features, including peripheral lymphoid cuffs with germinal centers (Fig. 8), a lack of hyalinized blood vessels, or a fibrous capsule (20). In contrast with conventional soft tissue schwannomas, secondary degenerative changes, such as central necrosis, hemorrhage, and hyalinization, are rarely present (19, 20). GI schwannomas are usually detected as incidental findings; however, they can present with symptoms of dysphagia, intestinal obstruction, or GI bleeding (18-20).

Fig. 8
Gastric schwannoma with cystic changes in 58-year-old woman.

Transabdominal US reveals a well-defined mass with homogenous internal echogenicity lower than that of normal muscularis propria. Some blood flow can be demonstrated in the mass on color Doppler US (21). On CT, GI schwannomas appear as well-demarcated round or oval, homogeneous masses (Fig. 8) with diverse growth patterns (intraluminal, extraluminal, or both). Moreover, GI schwannomas may enhance over time, with peak enhancement occurring during the equilibrium phase (18).


Gastritis Cystica Profunda

Gastritis cystica profunda (GCP) is an ectopic proliferation of gastric glandular elements, typically located beneath a normal mucosal layer. GCP is a rare submucosal lesion that is often reported in the setting of a prior gastroenterostomy (22). However, it can occasionally be found in the stomach without previous surgery, in which case it is often related to chronic gastritis or ischemia. Histologically, the lesion extends into the gastric submucosal layer and is composed of elongated hyperplastic gastric foveolae with hyperplasia and cystic dilation of the gastric glands (Fig. 9). This lesion presents as giant gastric folds, a submucosal tumor (Fig. 9), or an isolated polyp (gastritis cystica polyposa). Although commonly an incidental finding, GCP has been reported to be the cause of abdominal pain, bloating, gastric obstruction, and GI hemorrhage (23).

Fig. 9
Gastritis cystica profunda in 61-year-old woman.

Only a few reports exist describing the imaging characteristics of GCP. The contrast-enhanced CT findings include a homogeneously enhancing polypoid lesion or heterogeneously-enhancing gastric wall thickening, with or without small cystic components (24) (Fig. 9).

Brunner's Gland Hyperplasia

Brunner's glands consist of mucin-secreting glands that are normally located in the deep mucosa and submucosa of the duodenum. These glands protect the duodenal mucosa from the damaging effects of gastric acid. In addition, they extend from the pylorus to the second portion of the duodenum, up to the papilla, and may, in rare cases, extend to the proximal jejunum (25). Histologically, Brunner's gland hyperplasia may manifest as solitary or multiple small nodules composed of proliferating glands with maintenance of a lobular architecture and fibrous septa separating the hyperplastic lobules (Fig. 10). They can show a cystic appearance because of the dilatation of the glandular acini or ducts. Brunner's gland hyperplasia is clinically important because it can be mistaken for neoplastic lesions, although it is usually asymptomatic.

Fig. 10
Brunner's gland hyperplasia in 48-year-old man.

A barium study indicates that Brunner's gland hyperplasia commonly appears as smooth, polypoid lesions of the duodenum and may show markedly thickened, irregular folds in the proximal duodenum because of concomitant duodenitis (26). Moreover, Brunner's gland hyperplasia may be detected on transabdominal US as a lesion with a heterogeneous echotexture because of multiple small cysts (27). Only a few reports have described the various CT findings of Brunner's gland hyperplasia, including findings of a homogeneously-enhancing mass or of a heterogeneous and hypoattenuating mass with contrast administration (28, 29). In our study, CT revealed a solitary cystic lesion with mild wall enhancement (Fig. 10), which correlates with cystic dilatation of Brunner's glands.


Diagnosis of cystic lesions of the GI tract is difficult because of non-specific clinical manifestations and radiologic features. The clinical features of these lesions vary depending on the size and location of the lesion and they usually appear as a submucosal mass upon radiologic examinations. Despite the overlap of the radiologic appearance of various GI cystic lesions, the anatomic location and certain radiologic details of the lesion can help narrow the differential diagnosis. Finally, it is important for radiologists to be familiar with various disease categories and imaging characteristics of cystic lesions of the GI tract in order to facilitate the accurate diagnosis and proper management of such lesions.


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