Evidence suggests that nutrients involved in one-carbon metabolism are implicated in ovarian cancer etiology. No studies have evaluated the role of choline, and its metabolite, betaine. We prospectively examined the relationship between intake of these nutrients and ovarian cancer risk among 159,957 participants from the Nurses’ Health Study (NHS) and NHSII. Average nutrient intake was assessed every 2–4 years beginning in 1984 (NHS) and 1991 (NHSII). With up to 22 years of follow-up per cohort, there were 526 incident cases of ovarian cancer diagnosed. There were no associations between total choline, betaine, and choline plus betaine intake and ovarian cancer risk (e.g., relative risk, top vs bottom quintile of choline=0.98; 95%CI 0.73–1.31; Ptrend=0.81). Results did not vary by alcohol consumption, folate intake, or following exclusion of cases diagnosed during the 4-year period following dietary assessment. These data provide little evidence for a role of these nutrients in ovarian cancer etiology.
Keywords: ovarian cancer, betaine, choline