The CATIE–AD Study Group includes the following members:
Advisors and protocol committee — G. Alexopoulos, C.E. Davis, K.L. Davis, S. Davis, J.K. Hsiao, D.V. Jeste, I.R. Katz, K.R. Krishnan, G. Koch, B. Lebowitz, J.A. Lieberman, C.G. Lyketsos, D. Marin, B.G. Pollock, P.V. Rabins, R.A. Rosenheck, M. Sano, S. Schultz, G.W. Small, D. Sultzer; Trial center — K. Dagerman, M.S. Ismail, L.S. Schneider, P.N. Tariot;
NIMH staff — J. Baum, B. Bowers, D. Eskenazi, P. Gibbons, J. Gonzalez, W.R. Harlan, J.K. Hsiao, S. Hyman, T. Insel, B.D., Lebowitz, G.S. Norquist, J.T. Olin, L. Ritz, J.B. Severe;
University of North Carolina (UNC), Chapel Hill, and Duke University, Durham — J.A. Lieberman (formerly at UNC, currently at Columbia University) and C.E. Davis (principal investigators); R. Keefe (Duke University),
I. Rojas, S. Stroup (University of North Carolina at Chapel Hill), M. Swartz (Duke University);
Quintiles — S. Abbott, P.J. Butler, M. DiJohn, J. Ho, B. LaPlante, I. Amara, S. Davis, S. Kavanagh; VA New England MIRECC: Jennifer Cahill, Haiqun Lin PhD.
Study investigators — L. Adler, Clinical Insights, Baltimore; I. Ahmed, University of Hawaii, Honolulu; P. Aupperle, University of Medicine and Dentistry of New Jersey, Piscataway; S. Bartels, Dartmouth–Hitchcock Medical Center, Lebanon, NH; A. Baskys, Veterans Affairs Medical Center, Long Beach, CA; J. Beyer and M. Doraiswamy, Duke University Medical Center, Durham, NC; L. Blake, Northwestern University Medical School, Chicago; C.T. Cohen, SUNY Brooklyn, Brooklyn, NY; S. Colon, Veterans Affairs Medical Center, Tuscaloosa, AL; D. Devanand, Columbia University, New York; M. Dysken, Veterans Affairs Medical Center, Minneapolis; A. Freeman III, Louisiana State University Health Sciences Center, Shreveport; G.T. Grossberg, Saint Louis University, St. Louis; H. Grossman, Mount Sinai School of Medicine, New York; S. Gupta, Global Research and Consulting, Olean, NY; G. Haefner, Berman Research Group, Hialeah, FL; D. Jeste, University of California San Diego and Veterans Affairs Medical Center, San Diego; B. Jones and D. Johnston, Wake Forest University, Winston-Salem, NC; I. Katz and D. Weintraub, University of Pennsylvania and Veterans Affairs Medical Center, Coatesville; Z. Lebedeva and M. Parsa, Northeast Ohio Health Center, Columbus, OH; M.T. Levy, Staten Island University Hospital, Staten Island, NY; C.G. Lyketsos, Johns Hopkins University, Baltimore; D. McManus, Southern Illinois University, Springfield; J.E. Mintzer, Medical University of South Carolina, North Charleston; R. Ownby, University of Miami, Miami; E. Palmer, Lahey Clinic, Burlington, MA; E. Pfeiffer, University of South Florida Suncoast Gerontology Center, Tampa; N. Pomara, Nathan S. Kline Institute, Orangeburg, NY; S. Potkin, University of California Irvine, Irvine; J.M. Ryan, Monroe Community Hospital, Rochester, NY; C. Sadowsky, Palm Beach Neurology, West Palm Beach, FL; B. Saltz, Mental Health Advocates, Boca Raton, FL; S. Scheinthal, University of Medicine and Dentistry of New Jersey, Stratford; L.S. Schneider and S. Pawluczyk, University of Southern California, Los Angeles; S. Schultz, University of Iowa College of Medicine, Iowa City; J. Sheikh, Stanford University School of Medicine, Stanford, CA; F. Sicuro, Millennium Psychiatric Associates, St. Louis; P. Solomon, Southwestern Vermont Medical Center, Bennington, VT; D. Sultzer, Veterans Affairs Greater Los Angeles Healthcare System, University of California, Los Angeles, Los Angeles; L. Tune, Wesley Woods Health Center, Atlanta; C.H. van Dyck, Yale University School of Medicine, New Haven, CT; M. Weiner, University of Texas Southwestern Medical Center, Dallas.
Dr. Zheng, Dr. Mack, Ms. Dagerman, Dr. Hsiao, Dr. Lebowitz, Dr. Mack and Dr.Vigen, report no competing interests.
Dr. Lyketsos has received research funding from Forest, GlaxoSmithKline, Eisai, Pfizer, AstraZeneca, Eli Lilly, Ortho-McNeil, Bristol-Myers Squibb, Novartis, NIMH, the National Institute on Aging, and the Associated Jewish Federation of Baltimore, Weinberg Foundation; has received lecture honoraria or travel support from Pfizer, Forest, GlaxoSmithKline, and Health Monitor; and has served as consultant/adviser to AstraZeneca, GlaxoSmithKline, Eisai, Novartis, Forest, Supernus, Adlyfe, Takeda, Wyeth, Lundbeck, and Merz.
Dr. Stroup has served as a consultant for Janssen, Lilly, AstraZeneca, and Solvay. He has received honoraria for speaking at events sponsored by Lilly and Lundbeck.
Dr. Sultzer has received research funding from Forest and Pfizer, has received lecture honoraria from Forest, and has served as a consultant to Eli Lilly and AstraZeneca.
Dr. Tariot has received consulting fees from AC Immune, AstraZeneca, Avid, Baxter Healthcare, Eisai, Epix, Forest, Memory, Myriad, Pfizer, and Sanofi-Aventis; research support from Elan, Mitsubishi Pharma, Neurochem, Ono, the National Institute on Aging, NIMH, the Alzheimer’s Association, the Arizona Department of Health Services, and the Institute for Mental Health Research; consulting fees and research support from Abbott, GlaxoSmithKline, Merck, Merz, Takeda, and Wyeth; and educational fees from Lundbeck; he is also a contributor to the patent “Biomarkers of Alzheimer’s Disease.”
Dr. Schneider has been a consultant for Pfizer, Eli Lilly, Johnson & Johnson, AstraZeneca, and Bristol-Myers Squibb, all manufacturers of antipsychotic medication, and to Forest Pharmaceuticals and Lundbeck, manufacturers of citalopram. He has provided expert testimony in litigation involving Eli Lilly and Lundbeck, manufacturers of drugs used in this study.
The content of this article does not necessarily reflect the views or policies of the U.S. Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government.
This research was supported by NIMH research grant N01 MH-9001. AstraZeneca Pharmaceuticals, Forest Pharmaceuticals, Janssen Pharmaceutica (Johnson & Johnson), and Eli Lilly provided medications for this study.
Drs. Zheng, Mack, Vigen, and Schneider had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
A poster presentation of these results will be made in the “Hot Topics” session of the International Congress on Alzheimer’s Disease meeting, July 30, 2008, in Chicago.