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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
From:
Neurobiol Aging. Author manuscript; available in PMC 2010 October 1.
Published in final edited form as:
Neurobiol Aging. 2010 October; 31(10): 1710–1720.
Published online 2008 November 8. doi: 10.1016/j.neurobiolaging.2008.09.011

Table 5

Relationship of macroscopic vascular lesion scorea to clinical dementia, AD and VaD.

Any dementiabAlzheimer’s diseasecVascular dementiad



OR (95% CI) Model 1eOR (95% CI) Model 2fOR (95% CI) Model 1eOR (95% CI) Model 2fOR (95% CI) Model 1eOR (95% CI) Model 2f
Severity (0–6) (all)g1.6 (1.2–2.2)***1.6 (1.2–2.3)**1.4 (1.0–2.0)**1.5 (1.0–2.1)**2.1 (1.5–3.1)***2.0 (1.4–3.0)***
0 (n = 102)1 (reference)1 (reference)1 (reference)1 (reference)1 (reference)1 (reference)
1 (n = 26)2.4 (0.9–6.5)3.6 (1.1–12.2)1.6 (0.5–4.7)2.7 (0.7–10.2)6.9 (1.4–32.6)**8.5 (1.6–45.9)**
2 (n = 30)2.6 (0.97–7.1)2.5 (0.7–8.4)1.5 (0.5–4.5)1.4 (0.4–5.5)13.6 (3.2–58.1)***10.1 (2.0–50.8)**
3 or more (n = 32)8.4 (2.3–31.1)***9.1 (2.1–40.0)**4.7 (1.2–18.3)**5.6 (1.2–26.3)**33.1 (6.0–182.9)***27.9 (4.4–175.8)***
aMacroscopic vascular lesions score ranging 0–6 as outlined in Table 1.
bComparing overall demented to non-demented.
cComparing AD to non-demented excluding VaD and other dementias.
dComparing VaD to non-demented excluding AD and other dementias.
eAdjusted for age at death, sex, recruitment group, interval from last evaluation to death in months.
fAdditionally adjusted for other vascular lesions, Braak NFT stage and cortical Lewy bodies.
gUsing continuous variable for vascular lesion score.
**p value < 0.05.
***p value < 0.001.