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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
From:
Neurobiol Aging. Author manuscript; available in PMC 2010 October 1.
Published in final edited form as:
Neurobiol Aging. 2010 October; 31(10): 1710–1720.
Published online 2008 November 8. doi: 10.1016/j.neurobiolaging.2008.09.011

Table 4

Relationships of microscopic lesions to clinical diagnoses of dementia, AD or VaD.

Any dementiaa, no. of cases/total = 131/190Alzheimer’s diseaseb, no. of cases/total = 84/143Vascular dementiac, no. of cases/total = 28/87



Model 1d OR (95% CI)Model 2e OR (95% CI)Model 1d OR (95% CI)Model 2e OR (95% CI)Model 1d OR (95% CI)Model 2e OR (95% CI)
Microscopic vascular
  Microinfarcts0.8 (0.3–2.0)0.6 (0.2–1.9)0.6 (0.2–1.7)0.5 (0.1–1.7)1.7 (0.6–5.0)1.4 (0.3–5.7)
  Cribriform changes1.9 (0.7–5.0)1.7 (0.5–6.2)1.1 (0.4–3.3)1.1 (0.3–4.5)3.0 (0.9–10.1)1.9 (0.4–8.9)
  Cerebral amyloid angiopathy3.6 (1.5–8.6)**1.2 (0.4–3.7)4.0 (1.6–10.0)**1.2 (0.4–3.9)3.6 (1.2–11.1)**1.5 (0.4–5.8)
Neurodegenerative
  Braak Staging2.1 (1.6–2.7)***2.1 (1.6–2.9)***2.3 (1.7–3.0)***2.3 (1.7–3.2)***1.8 (1.3–2.5)***1.8 (1.2–2.7)**
  Cortical LB1.9 (0.9–4.1)1.9 (0.8–4.2)1.9 (0.9–4.0)1.8 (0.8–4.1)2.0 (0.9–4.5)2.2 (0.9–5.0)
aComparing overall demented to non-demented.
bComparing AD to non-demented excluding VaD and other dementias.
cComparing VaD to non-demented excluding AD and other dementias.
dAdjusted for age at death, sex, recruitment group, interval from last evaluation to death in months.
eAdditionally adjusted for other vascular lesions, Braak NFT stage and cortical Lewy bodies.
**p value < 0.05.
***p value < 0.001.