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Decay of the Ca2+ transient is not due to store depletion or to RYR1 inactivation. Representative fluorescence records of WT and Hom R163C myotubes loaded with Fluo-4 AM in response to a 10-s exposure to 20 mM caffeine (Caf) and a 180-s exposure to 60 mM [K+]e, followed by a second 10-s application of 20 mM caffeine (*) applied at different intervals (20–200 s) after the Ca2+ transient was elicited by 60 mM [K+]e. The decay of the Ca2+ transient during K+ depolarization does not appear to be related to SR Ca2+ depletion, nor is it due to RYR1 inactivation based on the amplitude of the second caffeine response (*).

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