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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Pediatr Allergy Immunol. Author manuscript; available in PMC 2010 June 18.
Published in final edited form as:
PMCID: PMC2887600

Relationship Between Infant Weight Gain and Later Asthma

Ian M. Paul, MD, MSc,1 Lindsay Camera,1 Robert S. Zeiger, MD, PhD,2 Theresa W. Guilbert, MD,3 Leonard B. Bacharier, MD,4 Lynn M. Taussig, MD,5 Wayne J. Morgan, MD,6 Ronina A. Covar, MD,7 Marzena Krawiec, MD,7 Gordon R. Bloomberg, MD,4 and David T. Mauger, PhD1, for the Childhood Asthma Research and Education (CARE) Network


Like obesity, the prevalence of asthma has increased over the past several decades. Accelerated patters of infant growth have been associated with obesity and its co-morbidities. We aimed to determine if infant weight gain pattern is associated with asthma development later in childhood. Birth weight, growth, pulmonary function, and symptom data were collected in a trial of 2–3 year old children at-risk for asthma randomized to a two-year treatment with inhaled corticosteroids or placebo followed by a one year observation period off study medication. Patterns of infant weight gain between birth and study enrollment were categorized as accelerated, average, or decelerated. Regression analyses were used to test the effects of infant weight gain pattern prior to study enrolment on outcomes during the observation year and at study conclusion while adjusting for demographics, baseline symptom severity, study treatment, and atopic indicators. Among the 197 study participants, early life weight gain pattern was not associated with daily asthma symptoms or lung function at the study’s conclusion. However, both prednisone courses (P=.01) and urgent physician visits (P<.001) were significantly associated with weight gain pattern with fewer exacerbations occurring amongst those with a decelerated weight gain pattern. We conclude that early life patterns of weight change were associated with subsequent asthma exacerbations, but were not associated with asthma symptoms or pulmonary function during the preschool years for these children at-risk for asthma.

Keywords: Asthma, Weight Gain, Infant


Accelerated or “rapid” weight gain during infancy has emerged as a strong risk factor for obesity in both childhood and adulthood.116 Some co-morbid chronic conditions related to obesity have also been independently linked to rate of weight gain during infancy such as hypertension,1720 coronary heart disease,21, 22 and type 2 diabetes mellitus.23, 24 Investigations into these associations began with the fetal growth restriction, or “Barker” hypothesis.25 This hypothesis linked retarded growth in utero and catch-up growth to subsequent morbidities related to cardiovascular health and insulin resistance.26, 27 As studies continued to evaluate this hypothesis, recent data have revealed that the rate of growth in the months after birth may be more important in determining future outcomes.4, 28 It has been theorized that over-nutrition in infancy adversely “programs” the components of the metabolic syndrome by promoting growth acceleration.29

Like obesity, the prevalence of asthma has increased over the past several decades.3033 While both low birth weight3442 and high body mass index in childhood4351 have been associated with an increased prevalence of asthma, a potential link between the two, rate of growth during childhood has received little attention. Therefore, we hypothesized that infant weight gain pattern would be associated with asthma development in a cohort of 2–3 year old children at high-risk for asthma enrolled in the Prevention of Early Asthma in Kids (PEAK) study.52 To test this hypothesis, asthma development was characterized by the two domains described in the new National Asthma Education and Prevention Program Guidelines: impairment and risk.53 The impairment domain is rooted in current burden of symptoms, quality of life, and functional capacity while the risk domain reflects adverse events, such as exacerbations of asthma and medication side effects.



Children 2 and 3 years of age with frequent intermittent wheezing at high risk of developing persistent asthma but currently without persistent symptoms were identified by meeting the criteria for a positive modified Asthma Predictive Index54 and enrolled in the PEAK trial. Major exclusion criteria included a history of prematurity of 35 weeks or less, growth less than the 10th percentile, chronic lung disease, or other major medical illness. The cohort meeting these inclusion and exclusion criteria was population based and identified by primary care physicians at the 5 clinical centers of the Childhood Asthma Research and Education Network, and the participants were screened for study eligibility based on inclusion and exclusion criteria that have been published previously in more detail.52, 55, 56

Study Design

Briefly, the PEAK trial was a multicenter, double-blind, randomized, placebo-controlled, parallel-group trial of inhaled fluticasone compared with placebo aimed to assess whether treatment of high-risk subjects with inhaled corticosteroids early in life could alter the natural history of asthma upon their cessation. For two treatment years, the participants received either inhaled corticosteroid (fluticasone propionate, 44 mcg/puff) or placebo, two puffs twice daily delivered through a valved spacer with a mask. Treatment was then stopped, and the subjects were then followed for an additional observation year when asthma symptoms and lung function were assessed. Institutional review boards at all participating centers approved the protocol and consent forms.

Study Procedures

As previously described in detail,52 data collected during the PEAK study included allergy skin testing, demographic data, and family history obtained at enrollment, symptom recall interviews, asthma medication use, and growth parameters throughout the study, and pulmonary function tests at the end of the study observation year. Upon study completion, birth weight was obtained via phone call or at an office visit on a sub-group of PEAK participants. Birth weight was reported by parents from several sources including birth certificates, baby books, medical records, and memory. Documented birth weights were obtained on 35% of participants while 65% were from memory, but importantly, parental recall of birth weight has been shown to be a reliable and accurate source of this information.5766 Enrollment weights were obtained at the study visit using clinic scales.

Episode-free days, exacerbations, and use of supplementary asthma medication were assessed by direct contact (by telephone or during a clinic visit) to evaluate asthma symptoms and medication use during the preceding 14 days and the use of healthcare resources since the last telephone call or clinic visit, as well as by review of the parents’ written records of all medication used by the children. Episode-free days were determined from the parents’ reported data, which were corrected according to the coordinators’ records in cases in which the family did not report previously prescribed supplementary controller medication that had been recorded and dispensed by the coordinators. The proportion of episode-free days for each participant was calculated as the number of episode-free days divided by the number of days of observation. Data from all participants were used in the analysis regardless of the number of days observed.

Data Analysis

After obtaining birth weight data, participants were categorized based upon their pattern of weight gain between birth and study enrollment at age 2 or 3 years. As has been done previously in numerous investigations, accelerated or “rapid” weight gain was defined as weight-for-age gains greater than 0.67 Z-scores between birth and study enrollment while decelerated or “slow” and average patterns of weight gain were defined as gains of less than −0.67 Z-scores and 0.67 to −0.67 Z-scores, respectively.2, 9, 10 These values were based upon the norms established from the 2000 Centers for Disease Control weight-for-age growth chart.67

Analysis of covariance was used to test for differences between patterns of weight gain with respect to the following continuous outcomes: episode free days, use of controller medicines, and pulmonary function testing. Pattern of weight gain was the factor of primary interest and covariates included demographics (age, sex, race/ethnicity, center), baseline symptom severity (number of episode free days during the study run-in period, duration of asthma-like symptoms prior to enrollment), treatment group, and indicators of atopy (aeroallergen skin test reactivity, percentage of blood eosinophils, and presence or absence of eczema). Unlike the episode free day analysis that used all three years of data, the outcome of use of controller medicines was based on data collected during the observation year only because the treatment group all received a controller medication during the treatment years of the study, Pulmonary function testing data were collected at the final study visit.

Poisson regression was used to test for differences between patterns of weight gain with respect to the following frequency outcomes: unscheduled physician visits and exacerbations requiring oral steroids over the three year study period. Exacerbations were defined as the need for a course of prednisolone to control asthma-like symptoms, These analyses were also adjusted for the covariates listed above.

Overall p-values for the test of the null hypothesis of no differences between the 3 patterns of weight gain are reported in Table 2. P-values for the three pairwise comparisons: slow vs. average weight gain, slow vs. rapid, and average vs. rapid are reported in Figure 1. Bonferroni correction to the standard 0.05 significance level is commonly used in this type of multiple comparison setting. Therefore, the statistical significance of these p-values could be assessed in comparison to 0.017 instead of 0.05. All analyses were carried out using the SAS statistical software package, version 9.1 (SAS Inc., Cary, NC).

Figure 1
Relationship Between Infant Weight Gain Group and a) systemic corticosteroid courses (P=.01 overall group comparisons) and b) unscheduled physician visits (P<.001 overall group comparisons) during the three year study period
Table 2
Relationship between Infant Weight Gain Group and Features of Asthma Impairment and Risk Domains at Ages 5–6 Years


Demographics and Baseline Characteristics

From the previously described PEAK cohort, birth weight data were obtained on 197/285 (69.1%), and this subgroup is the subject of the results of this analysis. The subjects with birth weight data were not significantly different from those without these data for any baseline characteristic. Among the 197 participants with data used for this analysis, 126 (64%) were male, and the mean age at study enrollment was 3.0 ± 0.6 years (Table 1). 58% of the cohort were classified by their parents to be White, and 42% were from racial or ethnic minority groups. Atopic features at enrollment were present in many of the participants with 122 (62%) having a positive aeroallergen skin test and 105 (53%) having a history of eczema. The median IgE level was 48.0 IU/mL (interquartile range 13.7–115.0 IU/mL).

Table 1
Demographic Variables and Baseline Characteristics

The mean birth weight for this subgroup was 3.4 ± 0.6 kg, equivalent to the 46th percentile on the 2000 Centers for Disease Control weight-for-age growth chart.67 Birth weight was not significantly correlated with any study outcomes with the exception of FEV0.5 (P<.001). At enrollment, the mean weight was 15.4 ± 2.4 kg, equivalent to the 62nd percentile of the growth chart. Between birth and study enrollment, 88/197 (45%) demonstrated an accelerated pattern of weight gain while 83 (42%) and 26 (13%) had average and decelerated patterns of weight change, respectively. At study enrollment, weight gain pattern was significantly associated with aeroallergen skin test positivity (P=.03) and IgE level (P=.02), with the decelerated group demonstrating the highest degree of atopy. No significant relationship was found between weight gain and eczema at enrollment.

Relationship between Infant Weight Gain Pattern and Later Asthma Outcomes

Impairment domain

The relationship between weight gain pattern and pulmonary function testing, episode free days, and days using controller medication were evaluated (Table 2). Because pulmonary function testing of the participants was done at a young age (mean age 5.8 ± 0.6 years), FEV0.5 was used instead of FEV1.68, 69 No significant relationship was found between weight change pattern during infancy and either FEV0.5 or FEV0.5/FVC when performed at age 5–6 years. For both episode free days and days using controller medication, data were analyzed only for the observation year. Again, no significant relationship was discovered between weight gain groups and these outcomes.

Risk domain

Significant differences were detected between weight gain patterns for the outcomes of exacerbations requiring systemic corticosteroids and unscheduled physician visits (Figure 1). For exacerbations requiring systemic corticosteroids, those with the slowest pattern of weight gain had a mean of 59.8 (95% CI 44.7–80.1) courses per 100 child years compared with 89.8 (78.0–103.5) for the average weight change group and 91.1 (79.6–104.4) for the children with accelerated weight gain (P=.01). Similarly, for unscheduled physician visits, significant differences again were detected between the decelerated group that had a mean of 53.1 (38.8–72.8) visits per 100 child years and the average and accelerated groups that had 98.3 (85.5–112.6) and 108.8 (95.9–123.4) visits per 100 child years, respectively (P<.001). Data regarding hospitalizations over the 3 year study period and weight change pattern were difficult to analyze because such events were rare; there were only 4 for the entire cohort over the 3 year study period. Analyses describing all outcomes were adjusted for demographics, baseline symptom severity, study treatment group, and atopic status.


Through study of the developmental origins of adult diseases, early life weight gain has been explored for its relationship with numerous diseases later in life.70 Associations have previously been found with obesity,114 hypertension,1720 coronary heart disease,21, 22 and type 2 diabetes mellitus.23, 24 The results of this study suggest that pattern of infant weight gain is associated with the risk domain of asthma morbidity for young children at high-risk for chronic asthma. Specifically, slower weight gain during the infant years relative to growth chart norms was protective for asthma exacerbations during the preschool years. Though no association was found between weight gain pattern and components of the impairment domain of asthma morbidity, the data describing an association between early life weight gain and asthma exacerbations does provide evidence of a link between early life growth and subsequent asthma for children.

Given the small sample size, the findings should be viewed as preliminary, but the results of our study are consistent with the single other report examining the relationship between early life weight gain and asthma outcomes by Rona et al.71 In that study, a cohort of 1232 Chilean children born between 1974 and 1978 were followed until a final study visit conducted between 2001 and 2003. Despite the collection of data on numerous variables related to birth and the infant period of life, only weight gain in the first year of life was significantly associated with wheezing illnesses during the 12 months prior to the final study assessment during adulthood.

Several previous studies have shown that increasing birth weight is inversely associated with subsequent asthma development.36, 37, 39, 40 Relating this fact to the current findings, children born heavier and near the upper percentile lines on the growth chart are less likely to upwardly cross major percentile lines due to the regression to the mean concept. Such children therefore are unlikely to have accelerated patterns of weight gain and more likely to have decelerated patterns of gain. The opposite is true for those born at lower weights who are unlikely to show decelerated patterns of growth and more likely to have accelerated weight gain during infancy. Though this study was underpowered to describe associations between asthma and birth weight, the current findings are related and consistent with an overall conceptual framework relating early life weight status to subsequent asthma outcomes.

Outside of infancy, the prevalence of asthma is associated with increased body mass index during childhood.4351 Further, overweight children were recently shown to have a higher hospital admission rate when presenting to the emergency department when compared with normal weight children with asthma.72 In addition to the studies examining single point weight measurements, weight change over time has also been associated with asthma symptoms for children. The Tucson Children’s Respiratory Study demonstrated that females who became overweight or obese between ages 6 and 11 years had an increased risk of developing new asthma symptoms and increased bronchial reactivity during the early adolescent period.73, 74 Similarly, the body mass index slope increases for those with unremitting asthma and unremitting wheezing were steeper than those with remitting asthma, remitting wheezing, or no wheezing.74 The investigators remarked that the prevention of accelerated weight gain during the school years could prevent asthma related morbidities.

Several mechanisms have been proposed to explain the relationship between obesity and asthma symptoms, and many of them can also be applied to weight gain pattern and accelerated weight gain during infancy, a time period where many confounders relevant to older subjects like sedentary lifestyle are not relevant. As recently reviewed by Shore,75 obesity is associated with mechanical factors, chronic systemic inflammation, and adipose tissue and energy-related hormones that all may be related to an individual’s asthma. Notably, accelerated weight gain during infancy has been associated with acquisition of adipose tissue as opposed to lean body mass.6, 9, 15, 76 The adipokines produced by adipose tissue may have a disease modifying effect.77 Further, co-morbidities of obesity such as gastroesophageal reflux disease can also contribute to asthma symptoms, and for infants, gastroesophageal reflux in particular is often clinically associated with overfeeding, which can lead to accelerated weight gain.

It is notable that the weight gain groups differed at baseline with respect to atopic status. Those in the decelerated group had higher IgE levels and were more likely to have aeroallergen skin test positivity. The fewer asthma exacerbations for this group is most likely explained by the fact that for toddlers, most exacerbations are induced by viral upper respiratory infections.

This analysis is limited by several factors. First, the data were generated from a prospective clinical trial, and the sample size and statistical power are therefore relatively small to describe associations between weight change and asthma outcomes. This fact may contribute to our inability to show any differences between the average weight gain group and those that had accelerated patterns of weight gain. Similarly, the lack of significant findings with asthma outcomes in the impairment domain should be viewed cautiously. Next, interval weight measurements between birth and study enrollment were not collected or available for analysis. It is possible that there is a critical early life period of growth that may have a stronger association with asthma outcomes than we were able to detect. A cohort followed from birth throughout childhood would be ideal to further evaluate the questions posed by this study. Further, data regarding other relevant perinatal covariates with relationships to infant weight status such as maternal body mass index and newborn gestational age were either unavailable or imprecise. Finally, this cohort was not representative of the general population or the overall population of asthmatic children, but rather a very specific cohort of young children with frequent intermittent wheezing at high risk for asthma development. Therefore, this report cannot be generalized to other populations, but instead can be used to prompt further studies.

In summary, the results of this analysis describe a relationship between weight gain pattern during infancy and components of asthma later in childhood, specifically those related to exacerbations. While the overall contribution of weight change to asthma morbidity may be relatively minor compared with genetics, atopic status, and environmental exposures,78 weight status and weight change over time are modifiable. If future studies confirm that weight change is associated with asthma exacerbations, interventions could be developed with asthma prevention as a goal.


This study was supported by Grants 5U10HL064287, 5U10HL064288, 5U10HL064295, 5U10HL064307, 5U10HL064305, 5U10HL064313 from the National Heart, Lung, and Blood Institute; General Clinical Research Centers at Washington University School of Medicine (M01 RR00036) and National Jewish Medical and Research Center (M01 RR00051)


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